| 李 璐,许光霞,宋彦峰,孟祥鹏,陈保增.脑脉利颗粒联合丁苯酞软胶囊对急性脑梗死患者脑血流动力学、血管内皮功能和神经损伤标志物水平的影响[J].,2023,(12):2358-2362 |
| 脑脉利颗粒联合丁苯酞软胶囊对急性脑梗死患者脑血流动力学、血管内皮功能和神经损伤标志物水平的影响 |
| Effects of Naomaili Granule Combined with Butylphthalide Soft Capsule on Cerebral Hemodynamics, Vascular Endothelial Function and Nerve Injury Markers in Patients with Acute Cerebral Infarction |
| 投稿时间：2022-12-30 修订日期：2023-01-23 |
| DOI：10.13241/j.cnki.pmb.2023.12.029 |
| 中文关键词: 脑脉利颗粒 丁苯酞软胶囊 急性脑梗死 脑血流动力学 血管内皮功能 神经损伤 |
| 英文关键词: Naomaili granule Butylphthalide soft capsule Acute cerebral infarction Cerebral hemodynamics Vascular endothelial function Nerve injury markers |
| 基金项目:山东省中医药科技发展计划项目（2019-0912） |
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| 摘要 目的：探讨脑脉利颗粒联合丁苯酞软胶囊对急性脑梗死患者脑血流动力学、血管内皮功能和神经损伤标志物水平的影响。方法：本研究为前瞻性设计，选取2021年1月~2022年6月期间我院收治的急性脑梗死患者150例。根据随机数字表法分为对照组（常规基础治疗+丁苯酞软胶囊治疗）和观察组（常规基础治疗+脑脉利颗粒联合丁苯酞软胶囊治疗），各为75例。观察两组疗效、美国国立卫生院神经功能缺损（NIHSS）评分、日常生活能力量表（ADL）评分和用药安全性，同时观察两组治疗前后的脑血流动力学、血管内皮功能和神经损伤标志物水平变化。结果：观察组的临床总有效率为96.00%，明显高于对照组的84.00%（P<0.05）。两组不良反应发生率对比无差异（P>0.05）。观察组治疗后ADL评分高于对照组同期，NIHSS评分低于对照组同期（P<0.05）。观察组治疗后脑血流收缩期峰值血流速度（Vs）、舒张期血流速度（Vd）、平均血流速度（Vm）高于对照组同期（P<0.05）。观察组治疗后内皮素-1（ET-1）低于对照组同期，一氧化氮（NO）高于对照组同期（P<0.05）。观察组治疗后神经元特异性烯醇化酶（NSE）、胶质纤维酸性蛋白（GFAP）及中枢神经特异性蛋白（S100?茁）低于对照组同期（P<0.05）。结论：脑脉利颗粒联合丁苯酞软胶囊可有效改善急性脑梗死患者脑血流动力学、血管内皮功能和神经损伤，发挥脑保护作用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Naomaili granule combined with butylphthalide soft capsule on cerebral hemodynamics, vascular endothelial function and nerve injury markers in patients with acute cerebral infarction. Methods: This study was a prospective design, and 150 patients with acute cerebral infarction who were admitted in our hospital from January 2021 to June 2022 were selected. According to the random number table method, they were divided into control group (conventional basic treatment combined with butylphthalide soft capsule treatment) and observation group (conventional basic treatment combined with Naomaili granule combined with butylphthalide soft capsule treatment), 75 cases in each group. The efficacy, National Institutes of Health Neurological deficit (NIHSS) score, Activity of daily Living scale (ADL) score and medication safety in the groups were observed. At the same time, The changes of cerebral hemodynamics, vascular endothelial function and nerve injury markers before and after treatment in the two groups were observed. Results: The total effective rate in the observation group was 96.00%, which was significantly higher than 84.00% in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions in the two groups (P>0.05). After treatment, the ADL score in the observation group was higher than that in the control group at the same period, the NIHSS score was lower than that in the control group at the same period (P<0.05). After treatment, the peak systolic blood flow velocity (Vs), diastolic blood flow velocity (Vd) and average blood flow velocity (Vm) in the observation group were higher than those in the control group at the same period (P<0.05). After treatment, endothelin-1 (ET-1) in the observation group was lower than that in the control group at the same period, nitric oxide (NO) were higher than those in the control group at the same period (P<0.05). After treatment, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP) and central nervous system specific protein (S100β) in the observation group were lower than those in the control group at the same period (P<0.05). Conclusion: Naomaili granule combined with butylphthalide soft capsule can effectively improve cerebral hemodynamics, vascular endothelial function and nerve injury in patients |
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