| 张 露,李娜娜,昝洪晶,刘新玲,薛玲玲.狼疮性肾炎患者血清和尿液sCD14、sCD163水平的表达及其临床意义[J].,2023,(12):2353-2357 |
| 狼疮性肾炎患者血清和尿液sCD14、sCD163水平的表达及其临床意义 |
| Expression and Clinical Significance of Serum and Urinary sCD14 and sCD163 in Patients with Lupus Nephritis |
| 投稿时间：2022-12-07 修订日期：2022-12-30 |
| DOI：10.13241/j.cnki.pmb.2023.12.028 |
| 中文关键词: 狼疮性肾炎 血清 尿液 sCD14 sCD163 临床意义 |
| 英文关键词: Lupus nephritis Serum Urinary sCD14 sCD163 Clinical significance |
| 基金项目:山东省医药卫生科技发展计划项目（2017SW0729) |
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| 中文摘要: |
| 摘要 目的：探讨狼疮性肾炎（LN）患者血清和尿液可溶性白细胞分化抗原14（sCD14）、可溶性白细胞分化抗原163（sCD163）水平的表达及其临床意义。方法：选取2019年12月至2022年6月我院肾内科收治的90例LN患者，根据系统性红斑狼疮疾病活动指数2000（SLEDAI-2000）评分将LN患者分为活动期LN组（＞4分，53例）和非活动期LN组（≤4分，37例），另选取45例于我院门诊体检的健康志愿者为对照组。检测各组血清和尿液中sCD14、sCD163水平，分析其与SLEDAI-2000评分及常规实验室指标的相关性。多因素Logistic回归分析LN患者处于疾病活动期的危险因素。结果：活动期LN组血清和尿sCD14、血清和尿sCD163水平均高于非活动期LN组、对照组（P＜0.05），且非活动期LN组血清和尿sCD14、血清和尿sCD163水平均高于对照组（P＜0.05）。LN患者血清和尿sCD14、血清和尿sCD163水平与SLEDAI-2000评分、尿蛋白、尿素氮、肌酐水平呈正相关（P＜0.05）。多因素Logistic回归分析显示，血清和尿sCD14、血清和尿sCD163及尿蛋白水平升高是LN患者处于疾病活动期的危险因素（P＜0.05）。结论：LN活动期患者血清和尿液sCD14、sCD163水平显著增高，高水平sCD14、sCD163与LN患者肾功能损伤以及LN疾病活动度增加有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of soluble leukocyte differentiation antigen 14 (sCD14) and soluble leukocyte differentiation antigen 163 (sCD163) in patients with lupus nephritis (LN). Methods: 90 patients with LN who were the Department of Nephrology in our hospital from December 2019 to June 2022 were selected. According to the systemic lupus erythematosus disease activity index 2000 (SLEDAI-2000) score, patients with LN were divided into active stage LN group (greater than4 scores, 53 cases) and non-active stage LN group (less than or equal to 4 scores, 37 cases), another 45 healthy volunteers who underwent physical examination in outpatient department of our hospital were selected as control group. The levels of serum and urinary sCD14 and sCD163 of each group were detected, and their correlation with SLEDAI-2000 score and routine laboratory indicators was analyzed. Multivariate Logistic regression analysis was used to analyze the risk factors of patients with LN in active disease stage. Results: The levels of serum and urinary sCD14, serum and urinary sCD163 in the active stage LN group were higher than those in the non-active stage LN group and control group (P＜0.05), and the levels of serum and urinary sCD14, serum and urinary sCD163 in the non-active stage LN group were higher than those in the control group (P＜0.05). The levels of serum and urinary sCD14, serum and urinary sCD163 in patients with LN were positively correlated with SLEDAI-2000 score, urinary protein, urea nitrogen and creatinine levels (P＜0.05). Multivariate Logistic regression analysis showed that increased serum and urinary sCD14, serum and urinary sCD163 and urinary protein levels were risk factors for patients with LN in the disease active stage (P＜0.05). Conclusion: The levels of serum and urinary sCD14 and sCD163 are significantly increased in patients with LN in the disease active stage, and high levels of sCD14 and sCD163 are associated with renal impairment and increased disease activity in patients with LN. |
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