| 吉雪莲,魏冬梅,蒋 虹,陈 霞,李 叶,张金秀.小儿推拿联合小儿消积止咳口服液和阿奇霉素治疗MPP患儿的临床疗效及对免疫功能和炎性因子的影响[J].,2023,(12):2343-2346 |
| 小儿推拿联合小儿消积止咳口服液和阿奇霉素治疗MPP患儿的临床疗效及对免疫功能和炎性因子的影响 |
| Clinical Efficacy of Pediatric Massage Combined with Xiaoer Xiaoji Zhike Oral Liquid and Azithromycin in the Treatment of Children with MPP and its Effect on Immune Function and Inflammatory Factors |
| 投稿时间：2022-11-23 修订日期：2022-12-20 |
| DOI：10.13241/j.cnki.pmb.2023.12.026 |
| 中文关键词: 推拿 小儿消积止咳口服液 阿奇霉素 肺炎支原体肺炎 疗效 免疫功能 炎性因子 |
| 英文关键词: Massage Xiaoer Xiaoji Zhike oral liquid Azithromycin Mycoplasma pneumoniae pneumonia Efficacy Immune function Inflammatory factors |
| 基金项目:四川省卫生和计划生育委员会科研项目（17PJ267） |
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| 中文摘要: |
| 摘要 目的：探讨小儿推拿联合小儿消积止咳口服液和阿奇霉素治疗肺炎支原体肺炎（MPP）患儿的临床疗效及对免疫功能和炎性因子的影响。方法：选取2018年3月-2019年6月期间在我院接受治疗的80例MPP患儿。按照治疗方法的不同分为对照组（阿奇霉素和小儿消积止咳口服液治疗，n=40）和研究组（小儿推拿、小儿消积止咳口服液、阿奇霉素治疗，n=40）。观察两组临床疗效以及治疗期间患儿症状改善情况，对比两组外周血T淋巴细胞亚群、不良反应和血清炎性因子。结果：与对照组比较，研究组的临床总有效率更高（P<0.05）。与对照组比较，研究组肺部啰音、咳嗽和X线片肺部病灶消失时间、退热时间均较短（P<0.05）。与对照组比较，研究组治疗14 d后CD3+、CD4+、CD4+/CD8+更高，CD8+更低（P<0.05）。与对照组比较，研究组治疗14 d后白介素-1β（IL-1β）、C反应蛋白（CRP）、白介素-6（IL-6）更低（P<0.05）。两组不良反应发生率对比无统计学差异（P>0.05）。结论：小儿推拿联合小儿消积止咳口服液和阿奇霉素治疗MPP患儿，可促进症状改善，优化临床治疗效果，可有效调节患儿免疫功能和炎性因子水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate clinical efficacy of pediatric massage combined with Xiaoer Xiaoji Zhike oral liquid and azithromycin in the treatment of children of mycoplasma pneumoniae pneumonia (MPP) and its effect on immune function and inflammatory factors. Methods: 80 cases of children with MPP who were treated in our hospital from March 2018 to June 2019 were selected. According to the different treatment methods, they were divided into the control group (azithromycin and Xiaoer Xiaoji Zhike oral liquid treatment, n=40) and the study group (pediatric massage, Xiaoer Xiaoji Zhike oral liquid, azithromycin treatment, n=40). The clinical efficacy of the two groups and the improvement of children's symptoms during the treatment were observed, peripheral blood T lymphocyte subsets, adverse reactions and serum inflammatory factors between the two groups were compared. Results: Compared with the control group, the clinical total effective rate of the study group was higher (P<0.05). Compared with the control group, the study group had a shorter of lung rales, cough and X-ray film of lung lesions to disappear time and antipyretic time (P<0.05). Compared with the control group, CD3+, CD4+ and CD4+/CD8+ in the study group was higher at 14 d after treatment, CD8+ was lower (P<0.05). Compared with the control group, interleukin-1β (IL-1β), C-reactive protein (CRP) and interleukin-6 (IL-6) in the study group were lower (P<0.05). There was no significant difference in incidence of adverse reactions in two groups (P>0.05). Conclusion: Pediatric massage combined with Xiaoer Xiaoji Zhike oral liquid and azithromycin in the treatment of children with MPP can promote the improvement of symptoms, optimize the clinical treatment effect, and effectively regulate the immune function and inflammatory factor levels of children. |
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