| 王 磊,来守勇,林 荫,郭 玲,高 孟.胸部CT联合血清糖类抗原-125、降钙素原、γ-干扰素诱导蛋白10对肺结核的诊断价值[J].,2023,(12):2291-2295 |
| 胸部CT联合血清糖类抗原-125、降钙素原、γ-干扰素诱导蛋白10对肺结核的诊断价值 |
| Diagnostic Value of Chest CT Combined with Serum Carbohydrate Antigen-125, Procalcitonin and Interferon-γ-Inducible Protein 10 for Pulmonary Tuberculosis |
| 投稿时间：2022-12-24 修订日期：2023-01-21 |
| DOI：10.13241/j.cnki.pmb.2023.12.016 |
| 中文关键词: 肺结核 CT 糖类抗原-125 降钙素原 γ-干扰素诱导蛋白10 诊断价值 |
| 英文关键词: Pulmonary tuberculosis CT Carbohydrate antigen-125 Procalcitonin Interferon-γ-inducible protein 10 Diagnostic value |
| 基金项目:北京市预防医学研究中心科研培训项目（016-BJYJ-08） |
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| 中文摘要: |
| 摘要 目的：探讨胸部电子计算机断层扫描（CT）联合血清糖类抗原-125（CA125）、降钙素原（PCT）、γ-干扰素诱导蛋白10（IP-10）对肺结核的诊断价值。方法：选择2020年1月至2022年1月我院收治的108例疑似肺结核患者，根据组织活检结果分为肺结核组（71例）和非肺结核组（37例）。所有患者均接受胸部CT检查，检测血清CA125、PCT、IP-10水平，采用受试者工作特征（ROC）曲线分析胸部CT联合血清CA125、PCT、IP-10诊断肺结核的价值。结果：108例疑似肺结核患者中71例确诊肺结核，检出率65.74%。肺结核患者胸部CT表现为大片实变影或散在多发斑片影，伴空洞、树芽征或胸腔积液、胸膜增厚、结节性病变。肺结核组血清CA125、PCT、IP-10水平高于非肺结核组（P＜0.05）。胸部CT、CA125、PCT、IP-10诊断肺结核的曲线下面积分别为0.759、0.715、0.688、0.727，胸部CT、CA125、PCT、IP-10联合诊断肺结核的曲线下面积为0.876，高于胸部CT、CA125、PCT、IP-10单独诊断。结论：胸部CT可显示肺结核典型病变特征，肺结核患者的血清CA125、PCT、IP-10水平显著增高，联合胸部CT、CA125、PCT、IP-10可提高对肺结核的诊断效能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the diagnostic value of chest computed tomography (CT) combined with serum carbohydrate antigen-125 (CA125), procalcitonin (PCT) and interferon-γ-inducible protein 10 (IP10) in pulmonary tuberculosis. Methods: 108 patients with suspected pulmonary tuberculosis who were admitted to our hospital from January 2020 to January 2022 were selected, and they were divided into pulmonary tuberculosis group (71 cases) and non-pulmonary tuberculosis group (37 cases) according to biopsy results. All patients underwent chest CT examination, the levels of serum CA125, PCT and IP-10 were detected. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of chest CT combined with serum CA125, PCT and IP-10 for pulmonary tuberculosis. Results: Among the 108 cases of patients with suspected tuberculosis, 71 cases were confirmed, with a detection rate of 65.74%. The chest CT findings of patients with pulmonary tuberculosis were large consolidation shadows or scattered multiple spots, accompanied by cavity, tree bud sign or pleural effusion, pleural thickening and nodular lesions. The levels of serum CA125, PCT and IP-10 in the pulmonary tuberculosis group were higher than those in the non-pulmonary tuberculosis group (P＜0.05). The area under curve of chest CT, CA125, PCT and IP-10 for the diagnosis of pulmonary tuberculosis was 0.759, 0.715, 0.688 and 0.727, respectively, the area under curve of chest CT, CA125, PCT and IP-10 for the diagnosis of pulmonary tuberculosis was 0.876, which was higher than chest CT, CA125, PCT, IP-10 alone diagnosis. Conclusion: Chest CT can show the typical lesion characteristics of pulmonary tuberculosis, and the levels of serum CA125, PCT and IP-10 in patients with pulmonary tuberculosis are significantly increased. The combination of chest CT, CA125, PCT and IP-10 can improve the diagnostic efficiency of pulmonary tuberculosis. |
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