| 周璟文,梁思雨,杨亲亲,刘夙璇,王国坤,克 文.血浆成纤维细胞激活蛋白含量在心肌梗死围手术期的临床意义[J].,2023,(12):2247-2251 |
| 血浆成纤维细胞激活蛋白含量在心肌梗死围手术期的临床意义 |
| The Clinical Significance of Plasma Fibroblast Activator Protein in Perioperative Period of Acute Myocardial Infarction |
| 投稿时间：2022-11-28 修订日期：2022-12-25 |
| DOI：10.13241/j.cnki.pmb.2023.12.008 |
| 中文关键词: 心肌梗死 成纤维细胞激活蛋白 心室重塑 纤维化 |
| 英文关键词: Myocardial infarction Fibroblast activation protein Ventricular remodeling Fibrosis |
| 基金项目:国家自然科学基金项目（81470592） |
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| 中文摘要: |
| 摘要 目的：明确血浆成纤维细胞激活蛋白（fibroblast activation protein，FAP）含量在心肌梗死患者围手术期的临床意义。方法：选取2021年11月至2022年4月入院接受经皮冠状动脉介入治疗（percutaneous coronary intervention，PCI）治疗的心肌梗死患者15例，年龄和性别匹配的健康者17例以及作为对照组。收集其血浆样本和影像学及其他相关临床资料，采用酶联免疫吸附法（enzyme linked immunosorbent assay，ELISA）测定循环血FAP的含量。并用配对t检验等统计学方法对其进行分析。结果：心肌梗死组循环血FAP的浓度为107.3±3.472 ng/mL，低于对照组（117.9±2.533 ng/mL），差异具有统计学意义（P<0.01）。心肌梗死组与对照组比较，其一般资料除cTnT外（P<0.01）无明显差异。心肌梗死患者循环血FAP水平在PCI术后显著下降，差异具有统计学意义（P<0.01）。PET-磁共振（PET-MR）检测结果显示心肌纤维化活跃程度较PCI术后初期明显降低。结论：心肌梗死患者PCI围手术期的血浆FAP水平与心肌纤维化的活跃程度有关。血浆FAP水平的变化曲线可为心肌梗死患者预后恢复的诊断提供参考依据。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical significance of plasma fibroblast activating protein (FAP) in patients with myocardial infarction during perioperative period. Methods: From November 2021 to April 2022, 15 patients with myocardial infarction who were admitted to the hospital for percutaneous coronary intervention (PCI) and 17 age- and sex-matched healthy subjects were selected as the control group. Plasma samples, imaging and other relevant clinical data were collected, and the content of FAP in circulating blood was determined by ELISA. It was analyzed by paired t test and other statistical methods. Results: The concentration of circulating blood FAP in AMI group was 107.3±3.472 ng/mL, which was lower than that in control group (117.9±2.533 ng/mL), and the difference was statistically significant (P<0.01). Compared with the control group, there was no significant difference in the general data except cTnT(P<0.01). The level of circulating blood FAP in patients with myocardial infarction decreased significantly after PCI (P<0.01). The results of PET-MR showed that the degree of myocardial fibrosis activity was significantly reduced compared with the initial stage after PCI. Conclusion: The plasma FAP level in patients with myocardial infarction during percutaneous coronary intervention (PCI) is related to the activity of myocardial fibrosis. The change curve of plasma FAP level can provide a reference for the diagnosis of prognosis and recovery of patients with myocardial infarction. |
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