| Objective: To explore the therapeutic effect of pain-alleviating formula combined with moist burn ointment on healing of postoperative anal fistula wounds and its influence on cell growth factors and pain stress. Methods: A total of 116 patients with anal fistula admitted to The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from May 2020 to June 2022 were divided into control group (58 cases, treated with moist burn ointment) and study group (58 cases, combined with pain-alleviating formula directed drug delivery) by random number table method. After 30 days of treatment, the changes in clinical efficacy, clinical indicators [wound healing rate, visual analogue scale (VAS) score, wound exudate score, wound edema score, granulation growth score], cell growth factors [vascular endothelial growth factor (VEGF), serum epidermal growth factor (EGF), fibroblast growth factor (bFGF)] and pain stress indicators [beta-endorphin (β-EP), substance P (SP)] were compared between the two groups. Results: The clinical total efficiency and wound healing rate of the study group were higher than those of the control group, while the VAS score, wound exudate score, wound edema score, granulation growth score of the study group were lower than those of the control group. The wound healing time of the study group was shorter than that of the control group (P<0.05). After treatment, the serum levels of EGF, VEGF, bFGF in the study group were higher than those in the control group (P<0.05). After treatment, the serum levels of β-EP and SP in the study group were lower than those in the control group (P<0.05). Conclusion: Pain-alleviating formula combined with moist burn ointment can promote wound healing after anal fistula surgery, which may be related to regulating serum cell growth factors and reducing pain stress. |
