| 杨学广,林 瑜,郭方亮,叶志飞,李 江.牙周基础治疗对慢性牙周炎伴冠心病患者血清炎症因子、龈下菌群和龈沟液中自噬因子的影响[J].,2023,(10):1955-1959 |
| 牙周基础治疗对慢性牙周炎伴冠心病患者血清炎症因子、龈下菌群和龈沟液中自噬因子的影响 |
| Effects of Periodontal Basic Treatment on Serum Inflammatory Factors, Subgingival Microflora, and Autophagy Factors in Gingival Crevicular Fluid in Patients with Chronic Periodontitis with Coronary Heart Disease |
| 投稿时间：2022-11-21 修订日期：2022-12-16 |
| DOI：10.13241/j.cnki.pmb.2023.10.029 |
| 中文关键词: 牙周基础治疗 慢性牙周炎 冠心病 炎症因子 龈下菌群 自噬因子 |
| 英文关键词: Periodontal basic treatment Chronic periodontitis Coronary heart disease Inflammatory factors Subgingival microflora Autophagy factor |
| 基金项目:四川省卫生计生委科研项目(150017) |
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| 中文摘要: |
| 摘要 目的：观察牙周基础治疗对慢性牙周炎伴冠心病患者血清炎症因子、龈下菌群和龈沟液中自噬因子的影响。方法：选择成都市第三人民医院口腔科2020年3月~2022年2月期间收治的慢性牙周炎伴冠心病患者83例。按照随机数字表法将患者分为对照组（n=41）和研究组（n=42），对照组接受常规内科维持治疗，研究组在对照组的基础上接受牙周基础治疗。对比两组牙周临床指标、血清炎症因子、龈下菌群、龈沟液中自噬因子的变化情况。结果：治疗3个月后，研究组牙龈指数（GI）、牙周附着丧失（AL）、牙周袋深度（PD）均低于对照组（P<0.05）。治疗3个月后，研究组C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白介素（IL）-1β、IL-6、IL-8、IL-17、IL-18低于对照组，IL-10高于对照组（P<0.05）。治疗3个月后，研究组牙龈卟啉单胞菌、伴放线菌嗜血菌、中间普雷沃菌、福赛斯坦纳菌、齿垢密螺旋体相对含量均低于对照组（P<0.05）。治疗3个月后，研究组微管相关蛋白1轻链3（LC3）、Beclin-1均低于对照组（P<0.05）。结论：牙周基础治疗可有效调节慢性牙周炎伴冠心病患者血清炎症因子水平，改善龈下菌群，降低龈沟液中自噬因子水平。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of periodontal basic treatment on serum inflammatory factors, subgingival microflora, and autophagy factors in gingival crevicular fluid in patients with chronic periodontitis with coronary heart disease. Methods: 83 patients with chronic periodontitis with coronary heart disease who were admitted to the Stomatology Department of Chengdu Third People's Hospital from March 2020 to February 2022 were selected. According to random number table method, patients were divided into control group (n=41) and study group (n=42). The control group received routine medical maintenance treatment, and the study group received periodontal basic treatment on the basis of the control group. The changes of periodontal clinical indicators, serum inflammatory factors, subgingival flora, serum inflammatory factors, autophagy factors in gingival crevicular fluid and periodontal clinical indicators between the two groups were compared. Results: 3 months after treatment, the gingival index(GI), periodontal attachment loss (AL) and periodontal pocket depth (PD) in the study group were lower than those in the control group(P<0.05). 3 months after treatment, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin (IL-1β), IL-6, IL-8, IL-17 and IL-18 in the study group were lower than those in the control group, and IL-10 was higher than that in the control group (P<0.05). 3 months after treatment, relative content of porphyromonas gingivalis, Hemophilus actinomycetes, Prevotella intermediate, Tannerella forsythia and Treponema serrata in the study group were lower than those in the control group (P<0.05). 3 months after treatment, microtubule-associated protein 1 light chain 3 (LC3) and Beclin-1 in the study group were lower than those in the control group(P<0.05). Conclusion: Periodontal basic treatment can effectively regulate the level of serum inflammatory factors in patients with chronic periodontitis with coronary heart disease, regulate the content of subgingival microflora, and reduce the level of autophagy factors in gingival crevicular fluid. |
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