| 郭呈林,赵进东,倪英群,方朝晖,张文锦.丹蛭降糖胶囊联合胰激肽原酶治疗2型糖尿病早期肾病的疗效及对肾功能、血糖指标的影响[J].,2023,(10):1907-1910 |
| 丹蛭降糖胶囊联合胰激肽原酶治疗2型糖尿病早期肾病的疗效及对肾功能、血糖指标的影响 |
| Efficacy of Danzhi Jiangtang Capsules Combined with Pancreatic Kininogenase in the Treatment of Early Type 2 Diabetic Nephropathy and Its Effect on Renal Function and Blood Sugar Indexes |
| 投稿时间：2022-09-14 修订日期：2022-10-12 |
| DOI：10.13241/j.cnki.pmb.2023.10.019 |
| 中文关键词: 丹蛭降糖胶囊 胰激肽原酶 2型糖尿病早期肾病 肾功能 血糖 |
| 英文关键词: Danzhi Jiangtang Capsule Pancreatic Kininogenase Early Type 2 Diabetes Nephropathy Renal Function Blood Sugar |
| 基金项目:国家自然科学基金项目（81774286）；安徽省名中医方朝晖工作室（2019-8-515） |
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| 中文摘要: |
| 摘要 目的：研究丹蛭降糖胶囊联合胰激肽原酶治疗2型糖尿病早期肾病的疗效及对肾功能、血糖指标的影响。方法：选择2021年1月～2022年7月于我院诊治的60例2型糖尿病早期肾病患者，将其随机分为两组。对照组单用胰激肽原酶治疗，观察组采用丹蛭降糖胶囊联合胰激肽原酶治疗。检测两组的肾功能指标、血糖指标[空腹血糖（FPG）、胰岛素抵抗指数（HOMA-IR）、空腹C肽（FCP）、餐后2 h血糖（PBG）、糖化血红蛋白（HbAlc）和餐后2hC肽（PCP）]，且检测两组的超敏C反应蛋白（hs-CRP）水平。结果：观察组的有效率高于对照组（P<0.05）；治疗后，两组的血清hs-CRP水平均降低，且观察组较对照组低（P<0.05）；治疗后，两组的血清肌酐、β2-微球蛋白、尿素和胱抑素C水平明显降低（P<0.05），且观察组的血清肌酐、β2-微球蛋白、尿素和胱抑素C水平明显低于对照组（P<0.05）；治疗后，两组的FPG、HOMA-IR、FCP、PBG、HbAlc和PCP水平均明显降低（P<0.05），且观察组的FPG、HOMA-IR、FCP、PBG、HbAlc和PCP水平明显低于对照组（P<0.05）。结论：丹蛭降糖胶囊联合胰激肽原酶对2型糖尿病早期肾病有显著的疗效，能明显改善肾功能和血糖指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Danzhi Jiangtang Capsules combined with pancreatic kininogenase in the treatment of early type 2 diabetic nephropathy and its effect on renal function and blood sugar indexes. Methods: A total of 60 patients with type 2 diabetes early nephropathy who were diagnosed and treated in our hospital from January 2021 to July 2022 were selected and randomly divided into two groups. The control group was treated with kallikrein alone, and the observation group was treated with Danzhi Jiangtang capsules combined with kallikrein. The renal function indexes, blood glucose indexes [fasting blood glucose (FPG), insulin resistance index (HOMA-IR), fasting C-peptide (FCP), 2 h postprandial blood glucose (PBG), glycosylated hemoglobin (HbAlc) and postprandial 2hC peptide (PCP)], and detected the level of high-sensitivity C-reactive protein (hs-CRP) in both groups. Results: The effective rate in the observation group was higher than that in the matched group(P<0.05); after treatment, the serum hs-CRP levels in both groups were decreased(P<0.05), and the serum hs-CRP levels in the observation group were lower than those in the matched group (P<0.05). After treatment, the levels of serum creatinine, β2-microglobulin, urea and cystatin C in the two groups were decreased (P<0.05), and the levels of serum creatinine, β2-microglobulin, urea and cystatin C in the observation group were decreased(P<0.05). The level of cystatin C was significantly lower than that in the matched group(P<0.05); After treatment, the levels of FPG, HOMA-IR, FCP, PBG, HbAlc and PCP in the two groups were decreased(P<0.05), and the FPG in the observation group was significantly lower(P<0.05), HOMA-IR, FCP, PBG, HbAlc and PCP levels were lower than those in the matched group(P<0.05). Conclusion: Danzhi Jiangtang Capsules combined with pancreatic kininogenase has a significant curative effect on early type 2 diabetes nephropathy, and can significantly improve renal function and blood sugar indicators. |
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