| 华婷琰,华 娴,闵 寒,杨建龙,陆筱祎.内镜下黏膜切除术治疗胃息肉的疗效及对血清ProGRP、PGI水平的影响[J].,2023,(9):1731-1735 |
| 内镜下黏膜切除术治疗胃息肉的疗效及对血清ProGRP、PGI水平的影响 |
| Effect of Endoscopic Mucosal Resection on Gastric Polyps and Serum ProGRP and PGI Levels |
| 投稿时间：2022-10-03 修订日期：2022-10-24 |
| DOI：10.13241/j.cnki.pmb.2023.09.026 |
| 中文关键词: 内镜下黏膜切除术 胃息肉 胃蛋白酶原I 胃泌素释放肽前体 炎症因子 |
| 英文关键词: Endoscopic mucosal resection Gastric polyps Pepsinogen I Gastrin releasing peptide precursor Inflammatory factors |
| 基金项目:江苏省高层次卫生人才"六个一工程"拔尖人才项目（LGY2018009） |
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| 中文摘要: |
| 摘要 目的：探讨内镜下黏膜切除术治疗胃息肉的疗效及对血清胃泌素释放肽前体（ProGRP）、胃蛋白酶原I（PGI）水平的影响。方法：选取我院2019年8月到2022年8月收治的120例胃息肉患者作为研究对象，依照手术方式的不同进行分组，其中将选择常规内镜下电凝切除术治疗的60例患者分为对照组，选择内镜下黏膜切除术治疗的60例患者分为观察组。对比两组患者不良反应发生情况与治疗费用，手术前与手术后血清ProGRP、PGI表达水平以及炎症因子表达水平，对比两组患者整体切除率和并发症发生情况。结果：两组患者总治疗费用对比无差异（P＞0.05），观察组患者术后不良反应发生率较对照组低（P＜0.05）；两组患者手术前血清ProGRP、PGI水平对比无差异（P＞0.05），治疗后两组患者均降低，且观察组较对照组低（P＜0.05）；两组患者手术前PCT、CRP、IL-6、IL-2对比无明显差异（P＞0.05），手术后两组患者PCT、CRP、IL-6、IL-2均升高，且观察组低于对照组（P＜0.05）；两组患者胃息肉均被完整切除，整体切除率对比无差异；且观察组穿孔、迟发性出血以及感染等并发症发生率虽低于对照组，但比较无差异（P＞0.05）。结论：对胃息肉患者采取内镜下黏膜切除术与常规内镜下电凝切除术均能够完整的切除胃息肉，且治疗费用相当。而应用内镜下黏膜切除术能够降低患者ProGRP、PGI水平，降低机体炎症因子反应，且并发症发生率较低，值得临床应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of endoscopic mucosal resection in the treatment of gastric polyps and its effect on the levels of serum gastrin releasing peptide precursor (ProGRP) and pepsinogen I (PGI). Methods: 120 patients with gastric polyps admitted in our hospital from August 2019 to August 2022 were selected as the research objects, and were divided into groups according to different surgical methods. Among them, 60 patients who were treated with conventional endoscopic electrocoagulation were divided into the control group, and 60 patients who were treated with endoscopic mucosal resection were divided into the observation group. The occurrence of adverse effects and treatment costs between the two groups, serum ProGRP, PGI expression levels and inflammatory factors expression levels before and after surgery, and the overall resection rate and complications in the two groups were compared. Results: There was no difference in the total treatment costs between the two groups (P>0.05). The incidence of postoperative adverse effects in the observation group was lower than that in the control group (P<0.05); There was no difference in serum ProGRP and PGI levels between the two groups before operation (P>0.05). After treatment, the ProGRP and PGI levels of the two groups decreased, and the observation group was lower than the matched group (P<0.05); There was no difference in PCT, CRP, IL-6 and IL-2 between the two groups before operation (P>0.05). After operation, PCT, CRP, IL-6 and IL-2 of the two groups increased, and the observation group was lower than the matched group (P<0.05); The gastric polyps were completely removed in both groups, and the overall resection rate was not different, and the incidence of perforation, delayed bleeding and infection was lower than that of the control group, but the difference was not significant (P>0.05). Conclusion: Both endoscopic mucosal resection and conventional endoscopic electrocoagulation can completely remove gastric polyps in patients with gastric polyps, and the treatment cost is equivalent. The application of endoscopic mucosal resection can reduce the levels of ProGRP and PGI in patients, reduce the inflammatory reaction of the body, and have a low incidence of complications, which is worthy of clinical application and promotion. |
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