| 胡绘姐,刘 攀,宣玮婷,项启旺,杜益刚,戴小华.基于心脾同治理论观察扶正养心汤对焦虑性失眠患者的临床疗效[J].,2023,(8):1497-1501 |
| 基于心脾同治理论观察扶正养心汤对焦虑性失眠患者的临床疗效 |
| Observation of the Clinical Effect of Fu Zheng Yang Xin Decoction on Anxiety Insomnia Patients Based on the Theory of Heart and Spleen Simultaneous Treatment |
| 投稿时间：2022-09-04 修订日期：2022-09-28 |
| DOI：10.13241/j.cnki.pmb.2023.08.019 |
| 中文关键词: 扶正养心汤 失眠 焦虑 心脾两虚 |
| 英文关键词: Fu Zheng Yang Xin Decoction Insomnia Neurasthenia Deficiency of Heart and Spleen |
| 基金项目:国家重点研发计划项目（2017YFC700306） |
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| 中文摘要: |
| 摘要 目的：观察扶正养心汤治疗心脾两虚型焦虑性失眠患者的临床疗效，探索扶正养心汤治疗心脾两虚型焦虑性失眠的可能性机制。方法：在中医情志病门诊就诊患者中，选取的心脾两虚型焦虑性失眠患者50例，按照随机数表法分为观察组和对照组各25例，对照组给予艾司唑仑片，1 mg，1次/d，观察组在对照上基础上加服扶正养心汤，2次/d，共14天，分别在治疗前后，比较两组患者WBC、IL-6、IgA表达水平以及生活质量评分（SF-36）、匹兹堡睡眠质量量表（PSQI）评分、焦虑自测量表（SAS）评分、中医证候积分及治疗后总有效率。结果：治疗后，组内相比，两组患者WBC、IL-6、IgA表达水平均较前下降（P＜0.05），两组患者PSQI评分、SAS评分均较治疗前降低（P＜0.05），SF-36评分较前升高（P＜0.05），观察组中医证候积分降低（P＜0.05），对照组中医证候积分降低无统计学差异（P＞0.05）；组间相比，观察组WBC、IL-6、IgA较对照组降低更明显（P＜0.05），SF-36较对照组提升更为明显（P＜0.05），PSQI评分和SAS评分降低更明显（P＜0.05），且总有效率更高（P＜0.05）。结论：扶正养心汤可改善心脾两虚型焦虑性失眠患者睡眠质量、临床症状和生活质量；相较于单纯使用艾司唑仑，疗效更佳。可能与扶正养心汤可降低患者WBC、IL-6、IgA水平相关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the clinical effect of Fu Zheng Yang Xin Decoction in treating anxiety insomnia with deficiency of both heart and spleen, and to explore the possibility mechanism of Fu Zheng Yang Xin Decoction to treat anxiety insomnia with deficiency of both heart and spleen. Methods: Among the patients in the traditional Chinese medicine (TCM) emotional diseases clinic, 50 patients with anxiety insomnia due to deficiency of both heart and spleen were selected, and divided them into observation group and control group by random number table method, 25 cases in each group. The control group was given estazolam tablets, 1 mg, 1 time/d, the observation group was given Fu Zheng Yang Xin Decoction on the basis of the control, 2 times/d, in a total of 14 days. Before and after the treatment, WBC, IL-6, IgA expression level, quality of life score (SF-36), the score by the Pittsburgh Sleep Quality Index (PSQI), Self-Rating Anxiety Scale (SAS) score, TCM syndrome score, and total efficiency of the two groups of patients were compared. Results: Post-treatment, compared within the group, the expression levels of WBC, IL-6 and IgA in the two groups were all decreased (P<0.05), and the PSQI and SAS scores of the two groups were decreased compared with those pretherapy (P<0.05). The SF-36 score was higher than before (P<0.05). Compared with the control group, the WBC, IL-6 and IgA of the observation group decreased more significantly than the control group (P<0.05), and the SF-36 increased more obviously than the control group (P<0.05), the PSQI score and SAS score decreased more significantly (P<0.05), and the total effective rate was higher (P<0.05). Conclusion: Fuzheng Yangxin Decoction can improve sleep quality, clinical symptoms and quality of life in patients with anxiety insomnia due to deficiency of both the heart and spleen. Compared with estazolam alone, the effect is better. It may be related to that Fuzheng Yangxin Decoction can reduce the levels of WBC, IL-6 and IgA in patients. |
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