| 黄婷婷,郑武田,刘梦莹,胡 宁,方 辉.传染性单核细胞增多症患儿NLR、CD4+/CD8+比值、ADA与EBV-DNA载量的相关性分析及对肝损害的影响[J].,2023,(7):1340-1344 |
| 传染性单核细胞增多症患儿NLR、CD4+/CD8+比值、ADA与EBV-DNA载量的相关性分析及对肝损害的影响 |
| Correlation Analysis of NLR, CD4+/CD8+ Ratio, ADA and EBV-DNA Load in Children with Infectious Mononucleosis and Their Effects on Liver Damage |
| 投稿时间：2022-08-23 修订日期：2022-09-18 |
| DOI：10.13241/j.cnki.pmb.2023.07.027 |
| 中文关键词: 传染性单核细胞增多症 NLR CD4+/CD8+比值 ADA EBV-DNA 相关性 肝损害 |
| 英文关键词: Infectious mononucleosis NLR CD4+/CD8+ ratio ADA EBV-DNA Correlation Liver damage |
| 基金项目:安徽省卫计委医学科研项目（16zc044）；合肥市第二人民医院院级课题（2021ygkt17） |
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| 中文摘要: |
| 摘要 目的：探讨传染性单核细胞增多症（IM）患儿外周血中性粒细胞/淋巴细胞比值（NLR）、CD4+/CD8+比值、腺苷脱氨酶（ADA）与EB病毒（EBV）-脱氧核糖核酸（DNA）载量的相关性，分析其对IM患儿肝损害的影响。方法：选择2019年1月至2022年4月我院儿科收治的102例IM患儿（IM组），另选择同期我科收治的95例EB病毒检测阴性的发热患儿（非IM组）和体检健康的73例健康儿童（对照组）。根据是否发生肝损害将IM患儿分为肝损害组（61例）和非肝损害组（41例）。比较外周血NLR、CD4+/CD8+比值、ADA与EBV-DNA载量，Pearson法分析NLR、CD4+/CD8+比值、ADA与EBV-DNA载量的相关性。多因素Logistic回归分析IM患儿发生肝损害的影响因素。结果：IM组ADA高于非IM组和对照组（P＜0.05），且非IM组高于对照组（P＜0.05），NLR、CD4+/CD8+比值低于非IM组和对照组（P＜0.05），且非IM组低于对照组（P＜0.05），IM组EBV-DNA载量高于非IM组（P＜0.05）。IM患儿ADA与EBV-DNA载量呈正相关（r=0.493，P＜0.05），NLR、CD4+/CD8+比值与EBV-DNA载量呈负相关（r=-0.419、-472，P＜0.05）。肝损害组ADA、EBV-DNA载量高于非肝损害组（P＜0.05），NLR、CD4+/CD8++比值低于非肝损害组（P＜0.05）。肝脏肿大、高EBV-DNA载量、高ADA是IM患儿肝损害的危险因素（P＜0.05），高NLR、高CD4+/ CD8+比值是保护因素（P＜0.05）。结论：IM患儿ADA增高，NLR、CD4+/CD8+比值降低，与EBV-DNA载量增加以及肝损害有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between peripheral blood neutrophils/lymphocytes ratio (NLR), CD4+/CD8+ ratio, adenosine deaminase (ADA) and Epbarr Barr virus (EBV) -deoxyribonucleic acid (DNA) load in children with infectious mononucleosis (IM), and to analyze the influence on liver damage in children with IM. Methods: 102 children with IM (IM group) who were admitted to the Department of Pediatrics of our hospital from January 2019 to April 2022 were selected, as well as 95 children with fever with negative EB virus (non-IM group) who were admitted to our department during the same period and 73 healthy children (control group) in physical examination were selected. The children with IM were divided into liver damage group (61 cases) and non-liver damage group (41 cases) according to whether they had liver damage. Peripheral blood NLR, CD4+/CD8+ ratio, ADA and EBV-DNA load were compared. Pearson method was used to analyze the correlation between NLR, CD4+/CD8+ ratio, ADA and EBV-DNA load. Multivariate Logistic regression analysis was used to the influencing factors of the occurrence of liver damage in children with IM. Results: ADA in the IM group was higher than that in the non-IM group and control group (P＜0.05), and the non-IM group was higher than the control group(P＜0.05), and the NLR and CD4+/CD8+ ratio were lower than those in the non-IM group and control group (P＜0.05), and the non-IM group was lower than the control group (P＜0.05), EBV-DNA load was higher in IM group than non IM group(P＜0.05). ADA was positively correlated with EBV-DNA load in the children with IM (r=0.493, P＜0.05), while NLR and CD4+/CD8+ ratio were negatively correlated with EBV-DNA load (r=-0.419, -472, P＜0.05). ADA and EBV-DNA load in the liver damage group were higher than those in the non-liver damage group (P＜0.05), and NLR and CD4+/CD8+ ratio were lower than those in the non-liver damage group(P＜0.05). Liver enlargement, high EBV-DNA load and high ADA were risk factors for liver damage in children with IM(P＜0.05), and high NLR and high CD4+/CD8+ ratio were protective factors (P＜0.05). Conclusion: The increase of ADA and the decrease of NLR and CD4+/CD8+ ratio in children with IM, and which are related to the increase of EBV-DNA load and liver damage. |
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