| 侯蓓蕾,熊亚丹,胡雷袁,邹 鑫,杨前勇.NLR、PLR、TyG指数与2型糖尿病肾病患者肾功能、胰岛素抵抗和颈动脉粥样硬化的关系[J].,2023,(7):1288-1293 |
| NLR、PLR、TyG指数与2型糖尿病肾病患者肾功能、胰岛素抵抗和颈动脉粥样硬化的关系 |
| Relationship between NLR, PLR, TyG Index and Renal Function, Insulin Resistance, Carotid Atherosclerosis in Patients with Type 2 Diabetes Nephropathy |
| 投稿时间：2022-10-07 修订日期：2022-10-30 |
| DOI：10.13241/j.cnki.pmb.2023.07.017 |
| 中文关键词: 2型糖尿病肾病 NLR PLR TyG指数 胰岛素抵抗 肾功能 颈动脉粥样硬化 |
| 英文关键词: Type 2 diabetic kidney disease NLR PLR TyG index Insulin resistance Renal function Carotid atherosclerosis |
| 基金项目:南京军区医药卫生课题重点项目（11z018） |
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| 中文摘要: |
| 摘要 目的：探讨中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、三酰甘油葡萄糖乘积（TyG）指数与2型糖尿病肾病（T2DKD）患者肾功能、胰岛素抵抗（IR）和颈动脉粥样硬化（CAS）的关系。方法：选取2018年2月～2022年2月我院收治的90例T2DKD患者作为T2DKD组，根据颈动脉超声检查结果将其分为CAS亚组（n=51）和非CAS亚组（n=39），另选取46例单纯2型糖尿病（T2DM）患者作为T2DM组和42名体检健康志愿者作为对照组。收集各组临床资料，估算肾小球滤过率（eGFR），并计算尿白蛋白/肌酐比值（UACR）、稳态模型胰岛素抵抗指数（HOMA-IR）、NLR、PLR、TyG指数。采用Spearman相关系数分析T2DKD患者NLR、PLR、TyG指数与肾功能指标和HOMA-IR的相关性，单因素、多因素Logistic回归分析T2DKD患者发生CAS的影响因素。结果：对照组、T2DM组、T2DKD组NLR、PLR、TyG指数、UACR、HOMA-IR依次升高，eGFR依次降低（P＜0.05）。Spearman相关系数显示，T2DKD患者NLR、PLR、TyG指数与UACR、HOMA-IR呈正相关，与eGFR呈负相关（P＜0.05）。多因素Logistic回归分析显示，年龄增加和HOMA-IR、UACR、NLR、PLR、TyG指数升高为T2DKD患者发生CAS的独立危险因素，eGFR升高为其独立保护因素（P＜0.05）。结论：T2DKD患者NLR、PLR、TyG指数升高，与肾功能下降、IR和CAS密切相关，可能成为T2DKD患者发生CAS风险的评估指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), triglyceride-glucose (TyG) index and renal function, insulin resistance (IR) and carotid atherosclerosis (CAS) in patients with type 2 diabetic kidney disease (T2DKD). Methods: 90 patients with T2DKD who were admitted to our hospital from February 2018 to February 2022 were selected as the T2DKD group, and they were divided into CAS subgroup (n=51) and non-CAS subgroup (n=39) according to the results of carotid ultrasound examination, and another 46 patients with pure type 2 diabetes mellitus (T2DM) were selected as the T2DM group and 42 healthy individuals on physical examination were selected as the control group. Clinical data of each group were collected, the estimated glomerular filtration rate(eGFR) was estimated, and the urinary albumin/creatinine ratio (UACR), homeostasis model assessment insulin resistance index (HOMA-IR), NLR, PLR and TyG index were calculated. Spearman correlation coefficient was used to analyze the correlation between NLR, PLR, TyG index and renal function index and HOMA-IR in patients with T2DKD. Univariate and multivariate Logistic regression was used to analyze the influencing factors of CAS in patients with T2DKD. Results: NLR, PLR, TyG index, UACR and HOMA-IR in the control group, T2DM group and T2DKD group were increased successively, while eGFR was decreased successively(P＜0.05). Spearman correlation coefficient showed that NLR, PLR and TyG index in patients with T2DKD were positively correlated with UACR and HOMA-IR, and negatively correlated with eGFR(P＜0.05). Multivariate Logistic regression analysis showed that the increased age and the elevated HOMA-IR, UACR, NLR, PLR and TyG index were independent risk factors for CAS in patients with T2DKD, and the elevated eGFR was independent protective factor (P＜0.05). Conclusion: Elevated NLR, PLR and TyG index in patients with T2DKD are closely associated with decreased renal function, IR and CAS, and which may be an index for assessing the risk of CAS in patients with T2DKD. |
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