| 陈 鹏,吕 光,赵宇浩,蒋 岩,尹述洲.麻醉诱导前给予依达拉奉与地塞米松联合BIS监测对胸腔镜下肺叶切除术后肺保护与术后恢复的影响[J].,2023,(6):1085-1090 |
| 麻醉诱导前给予依达拉奉与地塞米松联合BIS监测对胸腔镜下肺叶切除术后肺保护与术后恢复的影响 |
| Effects of Edaravone and Dexamethasone Combined with BIS Monitoring before Anesthesia Induction on Lung Protection and Postoperative Recovery after Thoracoscopic Lobectomy |
| 投稿时间：2022-08-08 修订日期：2022-08-31 |
| DOI：10.13241/j.cnki.pmb.2023.06.017 |
| 中文关键词: 依达拉奉 地塞米松 BIS监测 胸腔镜下肺叶切除术 肺保护 |
| 英文关键词: Edaravone Dexamethasone The BIS monitoring Thoracoscopic lobectomy Lung protection |
| 基金项目:江苏省苏州市民生科技医疗卫生应用基础研究（SYSD2019069） |
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| 中文摘要: |
| 摘要 目的：探讨麻醉诱导前给予依达拉奉与地塞米松联合BIS监测对胸腔镜下肺叶切除术后肺保护与术后恢复的影响。方法：选择2021年1月至2022年8月来我院行胸腔镜下肺叶切除术的患者80例。麻醉诱导前，A组静脉滴注100 mL 0.9 %生理盐水，B组静脉滴注30 mg依达拉奉，C组静脉滴注4 mg地塞米松注射液，D组静脉滴注30 mg依达拉奉及4 mg地塞米松，并对比四组患者相关指标。结果：四组患者的手术时间、麻醉时间、液体量及失血量对比无差异（P>0.05）。四组患者的心率、平均动脉压在T1-T4点时对比无差异（P>0.05）；四组患者的氧合指数、呼吸指数在T1、T2、T4点时对比无差异（P>0.05）；D组氧合指数较A、B、C组高，呼吸指数较A、B、C组低，B组与C组对比无差异（P>0.05），但氧合指数高于A组，呼吸指数低于A组（P<0.05）。T1、T2、T4点时，四组患者的血清IL-8、IL-10、TNF-α、SP-A水平及多形中性粒细胞数量对比无差异（P>0.05）；D组的SP-A水平较A、B、C组高，IL-8、IL-10、TNF-α及多形中性粒细胞数量较A、B、C组低，B组与C组对比无差异（P>0.05），但SP-A水平高于A组，IL-8、IL-10、TNF-α及多形中性粒细胞数量低于A组（P<0.05）。D组的术后住院时间较A、B、C组低，B组与C组对比无差异（P>0.05），但术后住院时间低于A组（P<0.05）。四组的肺炎、肺不张发生率对比无差异（P>0.05）。结论：麻醉诱导前给予依达拉奉联合地塞米松，同时给予BIS监测，可提高胸腔镜下肺叶切除术后肺保护作用，促进术后恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of edaravone and dexamethasone combined with BIS monitoring before anesthesia induction on lung protection and postoperative recovery after thoracoscopic lobectomy. Methods: A total of 80 patients who came to our hospital for thoracoscopic lobectomy from January 2021 to August 2022 were selected. Before induction of anesthesia, group A was given 100 mL of 0.9 % normal saline, group B was given 30 mg edaravone, group C was given 4 mg dexamethasone injection, and group D was given 30 mg edaravone Bong and 4 mg dexamethasone, and relevant indicators were compared between the four groups. Results: There was no difference in the operation time, anesthesia time, fluid volume and blood loss among the four groups (P>0.05). The heart rate and mean arterial pressure of the four groups of patients were not significant at points T1-T4 (P>0.05); the oxygenation index and respiratory index of the four groups of patients were not significant at points T1, T2, and T4 (P>0.05); the oxygenation index of group D was higher than that of groups A, B, and C, and the respiratory index was lower than that of groups A, B, and C. There was no significance between group B and group C (P>0.05), but the oxygenation index was lower than that of group A, B, and C. The index was higher than that of group A, and the respiratory index was lower than that of group A (P<0.05). At T1, T2, and T4, the serum IL-8, IL-10, TNF-α, SP-A levels and the number of polymorphic neutrophils in the four groups were not significant (P>0.05); group D Compared with groups A, B and C, the level of SP-A was higher, and the numbers of IL-8, IL-10, TNF-α and polymorphic neutrophils were lower than those in groups A, B and C (P<0.05). There was no statistical comparison between group B and group C (P>0.05). However, the level of SP-A was higher than that of group A, and the number of IL-8, IL-10, TNF-α and polymorphic neutrophils was lower than that of group A (P<0.05). The postoperative hospital stay in group D was lower than that in groups A, B and C, and there was no difference between group B and group C (P>0.05), but the postoperative hospital stay was lower than that in group A (P<0.05). There was no significance in the incidence of pneumonia and atelectasis among the four groups (P>0.05). Conclusion: Edaravone combined with dexamethasone before induction of anesthesia and BIS monitoring can improve the pulmonary protective effect and promote postoperative recovery after thoracoscopic lobectomy. |
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