| 张 力,申 鸿,郭 洁,雷 珂,安 哲,崔张珂,李 林.血清胰岛素样生长因子结合蛋白3、血清N端骨钙素、25羟基维生素D在骨质疏松检测价值分析[J].,2023,(5):914-917 |
| 血清胰岛素样生长因子结合蛋白3、血清N端骨钙素、25羟基维生素D在骨质疏松检测价值分析 |
| The Value of Serum Insulin-like Growth Factor Binding Protein 3, Serum N-terminal Osteocalcin and 25 Hydroxyvitamin D in The Detection of Psteoporosis |
| 投稿时间：2022-06-17 修订日期：2022-07-14 |
| DOI：10.13241/j.cnki.pmb.2023.05.022 |
| 中文关键词: 血清胰岛素样生长因子结合蛋白3 血清N端骨钙素 25羟基维生素D 骨质疏松 |
| 英文关键词: Serum insulin-like growth factor binding protein 3 Serum N-terminal osteocalcin 25 hydroxyvitamin D Osteoporosis |
| 基金项目:陕西省重点研发计划项目（2020SF-170） |
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| 中文摘要: |
| 摘要 目的：研究骨质疏松患者行血清胰岛素样生长因子结合蛋白3（IGFBP-3）、血清N端骨钙素（N-MID）、25羟基维生素D[25(OH)D]、骨密度（BMD）检测的效果。方法：数据取自本院2021年4月-2022年5月收治的80例骨质疏松患者，均行IGFBP-3、N-MID及25（OH）D检测，分析检测结果。结果：实验组患者的IGFBP-3、25(OH)D及N-MID、BMD水平均低于参照组患者相应指标水平（P<0.05）；实验组患者IGFBP-3、25(OH)D及N-MID、BMD变化水平相互为正相关关系（P<0.05）；采用多元回归分析显示影响BMD的主要因素中，IGFBP-3、25(OH)D、N-MID均为骨质疏松保护因素。结论：骨质疏松患者行IGFBP-3、25(OH)D及N-MID检测可切实观察病情、为疾病治疗提供参考数据，利于改善预后、效果显著。 |
| 英文摘要: |
| ABSTRACT Objective: To study the serum insulin-like growth factor-binding protein 3 (IGFBP-3), serum N-terminal osteocalcin (N-MID), 25-hydroxyvitamin D (25(OH)D), bone mineral density in osteoporosis patients (BMD) detection effect. Methods: Data were collected from 80 patients with osteoporosis who were admitted to our hospital from April 2021 to May 2022. Results: The levels of IGFBP-3, 25(OH)D, N-MID, and BMD in the research group were lower than those in the reference group (P<0.05). 25(OH)D, N-MID, and BMD levels were positively correlated with each other (P<0.05). Multiple regression analysis showed that among the main factors affecting BMD, IGFBP-3, 25(OH) D and N-MID are both protective factors for osteoporosis. Conclusion: The detection of IGFBP-3, 25(OH)D and N-MID in patients with osteoporosis can effectively observe the disease and provide reference data for disease treatment, which is beneficial to improve the prognosis and has a significant effect. |
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