| 刘 晶,胡喜姣,孙 淼,王 婧,常 萍.电针联合归脾汤对产后抑郁大鼠抑郁症状的影响及机制分析[J].,2023,(5):807-811 |
| 电针联合归脾汤对产后抑郁大鼠抑郁症状的影响及机制分析 |
| Effect and Mechanism Analysis of Electroacupuncture Combined with Guipi Decoction on Depressive Symptoms in Postpartum Depression Rats |
| 投稿时间：2022-10-08 修订日期：2022-10-31 |
| DOI：10.13241/j.cnki.pmb.2023.05.002 |
| 中文关键词: 电针 归脾汤 产后抑郁 |
| 英文关键词: Electric acupuncture Spleen-invigorating soup Postpartum depression |
| 基金项目:国家自然科学基金项目（81804138）；国家自然科学基金项目（82174195） |
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| 中文摘要: |
| 摘要 目的：探讨电针联合归脾汤对产后抑郁大鼠抑郁症状的影响及机制。方法：选择雌性SD大鼠36只，将36只大鼠随机分为正常组、模型组、盐酸氟西汀组、归脾汤组、电针组、归脾汤联合电针组，每组6只大鼠。空白组大鼠不进行任何处理。盐酸氟西汀组给予0.233 g/L盐酸氟西汀。归脾汤组给予1.72 g/mL归脾汤。电针组选择百会、印堂、气海、关元进行电针刺激。归脾汤联合电针组归脾汤用药方法同归脾汤组，电针方法同电针组。正常组及模型组子均给予等量的双蒸水。每组分别在造模后1周、2周时结束给药。对比糖水消耗水平、旷场实验评分及垂直评分、游泳实验不动时间、挣扎时间及游泳时间、血清HPA轴相关激素水平及大鼠脑组织中的5-HT含量。结果：与模型组相比，对照组、盐酸氟西汀组、归脾汤组、电针组大鼠在第1周、第2周时的糖水消耗水平、旷场实验评分、垂直评分、海马、额叶皮质中的5-HT水平较低，游泳实验不动时间、挣扎时间、游泳时间、促肾上腺皮质激素、促肾上腺皮质激素释放激素及皮质醇较高；与对照组相比，盐酸氟西汀组、归脾汤组、电针组大鼠呈相同趋势，与盐酸氟西汀组、归脾汤组、电针组相比，归脾汤联合电针组呈相同趋势（P<0.05）。盐酸氟西汀组、归脾汤组与电针组所有指标组间对比无差异（P>0.05）。结论：电针联合归脾汤可明显改善产后抑郁大鼠抑郁症状，可能与其可调节产后抑郁大鼠的HPA轴相关激素及5-HT水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect and mechanism of electroacupuncture combined with Guipi decoction on depressive symptoms in postpartum depression rats. Methods: 36 female SD rats were selected, and 36 rats were randomly assigned into normal, sham, model, fluoxetine hydrochloride, spleen soup, electroacupuncture, and 6 rats in each group. Blank group rats were treated without any treatment. The fluoxetine hydrochloride group was given 0.233 g/L of fluoxetine hydrochloride. The group was given 1.72 g/mL. Electroacupuncture group selected Baihui, Yintang, Qi hai and Guan Yuan for electroacupuncture stimulation. The method of the same spleen soup group and the same electric needle group. Equal amount of double steaming was given to the normal and model groups. Each group ended drug administration at 1 and 2 weeks after mold making. The sugar-water consumption level, absenteeism experiment score and vertical score, swimming experiment hyperactivity time, struggle time and swimming time, serum HPA axis-related hormone levels, and the 5-HT content in rat brain tissue were compared. Results: Compared with the model group, the sugar water consumption level, open field test score, vertical score, 5-HT levels in hippocampus and frontal cortex of rats in the control group, fluoxetine hydrochloride group, Guipi Decoction group and Electroacupuncture group were lower at week 1 and week 2. The immobilization time, struggle time, swimming time, adrenocorticotropic hormone, adrenocorticotropin-releasing hormone and cortisol were higher in swimming experiment. Compared with the control group, the fluoxetine hydrochloride group, Guipi decoction group and Electroacupuncture group showed the same trend, and compared with the fluoxetine hydrochloride group, Guipi decoction group and Electroacupuncture group, the Guipi decoction combined with Electroacupuncture group showed the same trend (P<0.05). There was no difference in all indexes between fluoxetine hydrochloride group, Guipi Decoction group and Electroacupuncture group(P>0.05). Conclusion: EA combined with Guipi decoction can significantly improve the depressive symptoms of postpartum depression rats, which may be related to the regulation of HPA axis-related hormone and 5-HT levels in postpartum depression rats. |
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