| 何旭斌,宦宗素,余芹瑶,杜 娜,岳玉川.不同焦虑程度青少年首发广泛性焦虑障碍患者血清NPY、5-HT、BDNF的变化及其与生活应激、炎症因子和记忆功能的相关性分析[J].,2023,(4):777-781 |
| 不同焦虑程度青少年首发广泛性焦虑障碍患者血清NPY、5-HT、BDNF的变化及其与生活应激、炎症因子和记忆功能的相关性分析 |
| Changes of Serum NPY, 5-HT, BDNF and Their Correlation Analysis with Life Stress, Inflammatory Factors and Memory Function in First-Episode Generalized Anxiety Disorder of Adolescents with Different Anxiety Levels |
| 投稿时间：2022-07-06 修订日期：2022-07-29 |
| DOI：10.13241/j.cnki.pmb.2023.04.034 |
| 中文关键词: 青少年 广泛性焦虑障碍 生活应激 炎症因子 记忆功能 神经肽Y 5-羟色胺 脑源性神经营养因子 |
| 英文关键词: Adolescents Generalized anxiety disorder Life stress Inflammatory factors Memory function Neuropeptide Y 5-hydroxytryptamine Brain-derived neurotrophic factor |
| 基金项目:四川省医学科研青年创新课题（Q20017） |
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| 中文摘要: |
| 摘要 目的：探讨不同焦虑程度青少年首发广泛性焦虑障碍（GAD）患者血清神经肽Y（NPY）、5-羟色胺（5-HT）、脑源性神经营养因子（BDNF）的变化及其与生活应激、炎症因子和记忆功能的相关性。方法：选择2019年1月至2021年12月成都市精神卫生中心收治的147例青少年首发GAD患者，根据广泛性焦虑量表（GAD-7）分为轻度焦虑组（5-9分，50例）、中度焦虑组（10-14分，65例）、重度焦虑组（15-21分，32例）。检测血清NPY、5-HT、BDNF、C反应蛋白（CRP）、白细胞介素（IL）-1α、IL-6水平，采用学生生活应激问卷（SLSI）、延迟匹配测验（DMS）评估生活应激水平和记忆功能。比较组间血清NPY、5-HT、BDNF、CRP、IL-1α、IL-6水平以及SLSI、DMS差异，分析血清NPY、5-HT、BDNF水平与血清CRP、IL-1α、IL-6水平及SLSI、DMS的相关性。结果：重度焦虑组血清NPY、5-HT、BDNF水平低于中度焦虑组和轻度焦虑组（P＜0.05），且中度焦虑组低于轻度焦虑组（P＜0.05），重度焦虑组CRP、IL-1α、IL-6水平以及SLSI评分高于中度焦虑组和轻度焦虑组（P＜0.05），且中度焦虑组高于轻度焦虑组（P＜0.05）。重度焦虑组总延迟反应时间、无延迟反应时间长于中度焦虑组和轻度焦虑组（P＜0.05），且中度焦虑组长于轻度焦虑组（P＜0.05）；重度焦虑组总延迟正确数、无延迟正确数少于中度焦虑组和轻度焦虑组（P＜0.05），且中度焦虑组少于轻度焦虑组（P＜0.05）。青少年首发GAD患者血清NPY、5-HT、BDNF水平与SLSI评分、CRP、IL-1α、IL-6、总延迟反应时间、无延迟反应时间呈负相关（P＜0.05），与总延迟正确数、无延迟正确数呈正相关（P＜0.05）。结论：青少年首发GAD患者随着焦虑程度加重，其生活应激强度增强、炎症因子水平升高，记忆功能减弱，且均与患者血清NPY、5-HT、BDNF水平降低有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the changes of serum neuropeptide Y (NPY), 5-hydroxytryptophan (5-HT) and brain-derived neurotrophic factor (BDNF) in first-episode generalized anxiety disorder (GAD) of adolescents with different anxiety levels and their correlation with life stress, inflammatory factors and memory function. Methods: 147 adolescent first-episode GAD patients who were admitted to Chengdu mental health center from January 2019 to December 2021 were selected, and they were divided into mild anxiety group (5-9 scores, 50 cases), moderate anxiety group (10-14 scores, 65 cases) and severe anxiety group (15-21 scores, 32 cases) according to the Generalized Anxiety Scale (GAD-7). Serum levels of NPY, 5-HT, BDNF, C-reactive protein (CRP), interleukin (IL) -1α and IL-6 were detected. Students' Life Stress Inventory (SLSI) and delayed matching test (DMS) were used to evaluate the life stress level and memory function. The levels of serum NPY, 5-HT, BDNF, CRP, IL-1α and IL-6 as well as SLSI and DMS were compared between groups, and the correlation between serum levels of serum NPY, 5-HT and BDNF and levels of serum CRP, IL-1α and IL-6 as well as SLSI and DMS were analyzed. Results: The levels of serum NPY, 5-HT and BDNF in severe anxiety group were lower than those in moderate anxiety group and mild anxiety group (P＜0.05), and the moderate anxiety group was lower than the mild anxiety group (P＜0.05). The levels of CRP, IL-1α and IL-6 and SLSI score in severe anxiety group were higher than those in moderate anxiety group and mild anxiety group (P＜0.05). The moderate anxiety group was higher than the mild anxiety group (P＜0.05). The total delayed response time and no delayed response time in the severe anxiety group were longer than those in the moderate anxiety group and the mild anxiety group (P＜0.05), and the moderate anxiety group was longer than the mild anxiety group (P＜0.05). The total delayed correct number and no delayed correct number in severe anxiety group were less than those in moderate anxiety group and mild anxiety group (P＜0.05), and the moderate anxiety group was less than the mild anxiety group (P＜0.05). The levels of serum NPY, 5-HT and BDNF were negatively correlated with SLSI score, CRP, IL-1α, IL-6, total delayed response time and no delayed response time (P＜0.05), and positively correlated with total delayed correct number and no delayed correct number (P＜0.05). Conclusion: With the aggravation of anxiety, life stress intensity, inflammatory factor level and memory function of adolescent first-episode GAD patients are enhanced, and all of them are related to the decrease of the levels of serum NPY, 5-HT and BDNF. |
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