| 王 艳,王利利,刘 伟,解民鹏,王 蓓.血必净注射液对重症急性胰腺炎患者肾功能、炎性因子和外周血单核细胞TLR4/NF-κB信号通路的影响[J].,2023,(4):709-713 |
| 血必净注射液对重症急性胰腺炎患者肾功能、炎性因子和外周血单核细胞TLR4/NF-κB信号通路的影响 |
| Effects of Xuebijing Injection on Renal Function, Inflammatory Factors and Peripheral Blood Mononuclear Cells TLR4/NF-κB Signaling Pathway in Patients with Severe Acute Pancreatitis |
| 投稿时间：2022-07-08 修订日期：2022-07-31 |
| DOI：10.13241/j.cnki.pmb.2023.04.021 |
| 中文关键词: 血必净注射液 重症急性胰腺炎 肾功能 炎性因子 外周血单核细胞TLR4/NF-κB信号通路 |
| 英文关键词: Xuebijing injection Severe acute pancreatitis Renal function Inflammatory factors Peripheral blood mononuclear cells TLR4/NF-κB signaling pathway |
| 基金项目:江苏省青年医学重点人才资助项目（QNRC2016486） |
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| 摘要 目的：探讨血必净注射液对重症急性胰腺炎（SAP）患者肾功能、炎性因子和外周血单核细胞Toll 样受体4（TLR4）/NF-κB信号通路的影响。方法：采用随机数字表法，将南京医科大学附属宿迁第一人民医院于2019年4月~2021年12月期间收治的重症SAP患者108例分为对照组（常规治疗，n=54）和观察组（n=54，对照组基础上结合血必净注射液）。对比两组肾功能、炎性因子和外周血单核细胞TLR4/NF-κB信号通路相关指标的变化情况。同时观察两组疗效、临床症状改善情况和不良反应发生情况。结果：观察组临床总有效率较对照组高（P<0.05）。两组不良反应率比较无差异（P>0.05）。与对照组比较，观察组腹胀腹痛缓解时间、体温恢复正常时间、恶心呕吐消失时间、住院时间更短（P<0.05）。两组治疗7 d后尿素氮（BUN）、血肌酐（Scr）下降（P<0.05），观察组治疗7 d后BUN、Scr低于对照组（P<0.05）。两组治疗7 d后白介素-6（IL-6）、白介素-1（IL-1）、肿瘤坏死因子-α（TNF-α）下降（P<0.05），治疗7 d后观察组IL-6、TNF-α、IL-1较对照组低（P<0.05）。两组治疗7 d后TLR4、NF-κB下降（P<0.05），观察组治疗7 d后TLR4、NF-κB低于对照组（P<0.05）。结论：血必净注射液可有效控制重症SAP患者炎性因子水平，减轻肾功能损伤，可能与调节外周血单核细胞TLR4/NF-κB信号通路有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Xuebijing injection on renal function, inflammatory factors and peripheral blood mononuclear cells toll like receptor 4 (TLR4) /NF-κB signaling pathway in patients with severe acute pancreatitis (SAP). Methods: Using the random number table method, 108 patients with severe SAP who were admitted to Suqian First People's Hospital Affiliated to Nanjing Medical University from April 2019 to December 2021 were divided into control group (conventional treatment, n=54) and observation group (n=54, control group combined with Xuebijing injection). The changes situation of renal function, inflammatory factors and peripheral blood mononuclear cells TLR4/NF-κB signaling pathway were compared in two groups. The efficacy, improvement of clinical symptoms and occurrence of adverse reactions in two groups were observed at the same time. Results: The total effective rate in observation group was higher than that in control group (P<0.05). There was no difference in the adverse reaction rate in two groups (P>0.05). Compared with the control group, the relief time of abdominal distension and pain, the time of body temperature returning to normal, the disappearance time of nausea and vomiting and the length of hospital stay in observation group were shorter (P<0.05). Urea nitrogen (BUN) and serum creatinine (Scr) in two groups at 7d after treatment decreased (P<0.05), and BUN and Scr in observation group at 7 d after treatment were lower than those in control group (P<0.05). 7 d after treatment, interleukin-6 (IL-6), interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) in two groups decreased (P<0.05), and 7 d after treatment, the IL-6, TNF-α and IL-1 in observation group were lower than those in control group (P<0.05). 7 d after treatment, TLR4 and NF-κB in two groups decreased (P<0.05), and 7 d after treatment, TLR4 and NF-κB in observation group were lower than those in control group (P<0.05). Conclusion: Xuebijing injection can effectively control the level of inflammatory factors in patients with severe SAP, reduce the damage of renal function, and which may be regulate the peripheral blood mononuclear cells TLR4/NF-κB signaling pathway. |
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