| 喻 超,祝 康,王波涛,孙 斌,夏 翠.鼻咽癌组织CTHRC1 mRNA、c-IAP2 mRNA表达水平与临床病理特征和预后的关系分析[J].,2023,(4):704-708 |
| 鼻咽癌组织CTHRC1 mRNA、c-IAP2 mRNA表达水平与临床病理特征和预后的关系分析 |
| Relationship between CTHRC1 mRNA, c-IAP2 mRNA Expression and Clinicopathological Features and Prognosis in Nasopharyngeal Carcinoma |
| 投稿时间：2022-07-27 修订日期：2022-08-23 |
| DOI：10.13241/j.cnki.pmb.2023.04.020 |
| 中文关键词: 鼻咽癌 胶原三股螺旋重复蛋白1 细胞凋亡抑制蛋白2 临床病理特征 预后 |
| 英文关键词: Nasopharyngeal carcinoma Collagen Triple Helix Repeat-Containing 1 Protein c-inhibitor of apoptosis protein 2 Clinicopathological features Prognosis |
| 基金项目:陕西省自然科学基础研究计划项目（2021JQ418） |
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| 中文摘要: |
| 摘要 目的：探讨鼻咽癌组织中胶原三股螺旋重复蛋白1（CTHRC1）信使核糖核酸（mRNA）、细胞凋亡抑制蛋白2 （c-IAP2）mRNA表达与临床病理特征和预后的关系。方法：选择2016年5月至2019年1月我院收治的82例鼻咽癌患者，取活检鼻咽癌组织，采用实时荧光定量聚合酶链反应（qRT-PCR）检测CTHRC1 mRNA、c-IAP2 mRNA表达，患者治疗结束后接受定期电话随访或定期回院复查，随访持续时间为3年。比较不同临床病理特征鼻咽癌组织中CTHRC1、c-IAP2 mRNA表达差异，绘制Kaplan-Meier生存曲线，分析不同CTHRC1 mRNA、c-IAP2 mRNA表达的鼻咽癌患者3年总生存率（OS）差异。单因素和多因素Cox比例风险回归模型分析影响鼻咽癌患者预后的危险因素。结果：低度分化、TNM Ⅳ期、淋巴结转移、颅底侵犯的鼻咽癌组织中CTHRC1mRNA、c-IAP2 mRNA表达均高于高、中度分化、TNM Ⅲ期、无淋巴结转移、无颅底侵犯的鼻咽癌组织（P＜0.05）。CTHRC1mRNA高表达、c-IAP2 mRNA高表达患者3年OS低于CTHRC1mRNA低表达、c-IAP2 mRNA低表达患者（log-rank χ2=7.088、5.511，P＜0.05）。多因素Cox比例风险回归分析结果显示TNM分期IV期、淋巴结转移、高表达CTHRC1mRNA、高表达c-IAP2 mRNA是鼻咽癌患者预后不良的危险因素（P＜0.05）。结论：鼻咽癌组织 CTHRC1 mRNA、c-IAP2 mRNA表达均异常升高，高表达CTHRC1 mRNA、c-IAP2 mRNA与鼻咽癌恶性病理特征以及预后不良有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of collagen triple helix repeat protein 1 (CTHRC1) messenger ribonucleic acid (mRNA) and inhibitor of apoptosis protein 2 (c-IAP2) mRNA in nasopharyngeal carcinoma (NPC) and its clinicopathological characteristics and prognosis. Methods: Eighty-two patients with nasopharyngeal carcinoma who were admitted to our hospital from May 2016 to January 2019 were selected.The nasopharyngeal carcinoma tissues were taken for biopsy, and the expression of CTHRC1 mRNA and c-IAP2 mRNA was detected by real-time fluorescence quantitative polymerase chain reaction (qRT-PCR). After treatment, the patients were regularly followed up by telephone or returned to the hospital for reexamination. The follow-up lasted for 3 years. The difference in the expression of CTHRC1 and c-IAP2 mRNA in nasopharyngeal carcinoma tissues with different clinicopathological characteristics were compared, draw Kaplan Meier survival curve, and the 3-year overall survival rate (OS) difference of nasopharyngeal carcinoma patients with different expressions of CTHRC1 mRNA and c-IAP2 mRNA were analyzed. Univariate and multivariate Cox proportional hazard regression models were used to analyze the risk factors affecting the prognosis of patients with nasopharyngeal carcinoma. Results: The expression of CTHRC1 mRNA and c-IAP2 mRNA in nasopharyngeal carcinoma tissues with low differentiation, TNM stage IV, lymph node metastasis and skull base invasion was higher than that in nasopharyngeal carcinoma tissues with high and moderate differentiation, TNM stage III, no lymph node metastasis and skull base invasion (P<0.05). OS in patients with high expression of CTHRC1 mRNA and high expression of c-IAP2 mRNA was lower than that in patients with low expression of CTHRC1 mRNA and low expression of c-IAP2 mRNA for 3 y2ars (log-rank χ2=7.088,5.511, P<0.05). Multivariate Cox proportional hazard regression analysis showed that TNM stage IV, lymph node metastasis, high expression of CTHRC1 mRNA, and high expression of c-IAP2 mRNA were risk factors for poor prognosis of NPC patients (P<0.05). Conclusion: The expression of CTHRC1 mRNA and c-IAP2 mRNA in nasopharyngeal carcinoma is abnormally elevated. The overexpression of CTHRC1 mRNA and c-IAP2 mRNA is related to the malignant pathological characteristics and poor prognosis of nasopharyngeal carcinoma. |
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