| 吕秀芳,李 燚,邵 琳,王 超,营在道.清宫止带汤联合利普刀治疗中重度宫颈糜烂湿热下注证的临床研究[J].,2023,(3):597-600 |
| 清宫止带汤联合利普刀治疗中重度宫颈糜烂湿热下注证的临床研究 |
| Clinical Study of Qinggong Zhidai Decoction Combined with LEEP Knife on Moderate and Severe Cervical Erosion with Damp-Heat Pouring Downward Syndrome |
| 投稿时间：2022-06-20 修订日期：2022-07-15 |
| DOI：10.13241/j.cnki.pmb.2023.03.040 |
| 中文关键词: 清宫止带汤 利普刀 宫颈糜烂 湿热下注证 肿瘤坏死因子-?琢 白细胞介素-1 白细胞介素-6 |
| 英文关键词: Qinggong Zhidai decoction LEEP knife Cervical erosion Damp-heat betting syndrome TNF-?琢 IL-1 IL-6 |
| 基金项目:山东省医药卫生科技发展计划立项项目（20182WS283） |
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| 中文摘要: |
| 摘要 目的：探讨清宫止带汤联合利普刀治疗中重度宫颈糜烂湿热下注证的疗效以及对血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）以及白细胞介素-6（IL-6）水平的影响，以期为中重度宫颈糜烂的治疗提供可借鉴临床方案。方法：纳入2020年5月至2022年5月于山东省立第三医院收治的宫颈糜烂患者120例，根据随机数字表法分入对照组与观察组，各60例。对照组患者单纯行利普刀及术后常规治疗；观察组在对照组基础上加服清宫止带汤，两组连续观察14d。比较两组临床疗效，症状改善时间，药物不良反应发生情况及血清TNF-α、IL-1、IL-6水平。结果：观察组的总有效率（98.33％）较对照组（86.67％）显著增加（P＜0.05）。观察组的阴道出血及阴道排液持续时间较对照组显著降低（P＜0.01）。观察组的不良反应率（1.67%）较对照组（15.00%）显著降低（P＜0.05）。治疗后，两组血清TNF-α、IL-1、IL-6水平显著降低，但观察组降低更显著（P＜0.01）。结论：清宫止带汤联合利普刀治疗中重度宫颈糜烂湿热下注证的疗效确切，患者症状改善时间缩短、炎症反应降低，且安全性更好，值得临床应用与借鉴。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the curative effect of Qinggong Zhidai decoction combined with LEEP knife in the treatment of moderate and severe cervical erosion with damp-heat diffusing downward syndrome and its influence on the levels of serum tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6), so as to provide a clinical scheme for the treatment of moderate and severe cervical erosion. Methods: A total of 120 patients with cervical erosion admitted to Shandong Provincial Third Hospital from May 2020 to May 2022 were included and divided into control group and observation group according to random number table method, with 60 cases in each group. Patients in the control group were treated with LEEP knife and postoperative routine treatment, the observation group was treated with Qinggong Zhidai Decoction on the basis of the control group, and the two groups were observed continuously for 14 d. The clinical efficacy, symptom improvement time, adverse drug reactions and serum TNF-α, IL-1, IL-6 levels were compared between the two groups. Results: The total effective rate of the observation group (98.33%) was significantly higher than that of the control group (86.67%)(P<0.05).The duration of vaginal bleeding and vaginal discharge in the observation group was significantly lower than that in the control group (P<0.01). The adverse reaction rate of the observation group(1.67%) was significantly lower than that of the control group(15.00%)(P<0.05). After treatment, the levels of serum TNF-α, IL-1 and IL-6 in the two groups were significantly decreased, but the decrease in the observation group was more significant(P<0.01). Conclusion: The curative effect of Qinggong Zhidai Decoction combined with LEEP knife in the treatment of moderate to severe cervical erosion with damp-heat betting syndrome is definite, the improvement time of symptoms is shortened, the inflammatory reaction is reduced, and the safety is better, which is worthy of clinical application and reference. |
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