| 李明路,郭晓莉,于亚明,周 宁,孙付国.解毒化瘀汤联合刺络放血疗法对血瘀热结证寻常型银屑病患者血清炎性因子及CREB信号传导通路相关蛋白表达的影响[J].,2023,(3):579-583 |
| 解毒化瘀汤联合刺络放血疗法对血瘀热结证寻常型银屑病患者血清炎性因子及CREB信号传导通路相关蛋白表达的影响 |
| Effect of Jiedu Huayu Decoction Combined with Blood Letting Puncture Therapy on the Expression of Serum Inflammatory Factors and CREB Signal Transduction Pathway Related Proteins in Patients with Psoriasis Vulgaris of Blood Stasis Heat Stagnation Syndrome |
| 投稿时间：2022-05-22 修订日期：2022-06-17 |
| DOI：10.13241/j.cnki.pmb.2023.03.036 |
| 中文关键词: 解毒化瘀汤 刺络放血疗法 血瘀热结证 寻常型银屑病 炎性因子 CREB信号传导通路 |
| 英文关键词: Jiedu Huayu decoction Blood letting puncture therapy Blood stasis heat stagnation syndrome Psoriasis vulgaris Inflammatory factors CREB signal transduction pathway |
| 基金项目:四川省科技计划项目（2016YJ02717） |
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| 中文摘要: |
| 摘要 目的：探讨解毒化瘀汤联合刺络放血疗法对血瘀热结证寻常型银屑病患者血清炎性因子及cAMP反应元件结合蛋白（CREB）信号传导通路相关蛋白表达的影响。方法：选取2018年5月到2020年5月武警成都支队卫生队和武警四川总队医院收治的寻常型银屑病患者共80例，随机分成对照组（维A酸哈西奈德乳膏治疗）与观察组（解毒化瘀汤联合刺络放血疗法治疗），各40例。两组均以4周为1个疗程，共治疗2个疗程。对比两组疗效、中医证候积分、血清炎性因子及CREB信号传导通路相关蛋白表达水平。结果： 观察组的临床总有效率高于对照组（P<0.05）。两组治疗后中医证候主证、次证总评分和血清白介素-17（IL-17）、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）、C反应蛋白（CRP）水平以及CREB微小核糖核酸（mRNA）、PKA mRNA、P38 mRNA相对表达量均较治疗前下降，且观察组较对照组低（P<0.05）。结论：解毒化瘀汤联合刺络放血疗法治疗血瘀热结证寻常型银屑病患者，疗效显著，可有效改善临床症状，减轻机体炎性反应，其主要作用机制可能与调节CREB信号传导通路相关蛋白表达有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Jiedu Huayu decoction combined with blood letting puncture therapy on the expression of serum inflammatory factors and cAMP response element protein (CREB) signal transduction pathway related proteins in patients with psoriasis vulgaris of blood stasis heat stagnation syndrome. Methods: A total of 80 patients with psoriasis vulgaris treated in the Health Team of Chengdu detachment of Armed Police and the Sichuan Armed Police Corps Hospital were selected, they were randomly divided into control group (hasinonide retinoate cream treatment) and observation group (Jiedu Huayu decoction combined with blood letting therapy), with 40 cases in each group. Both groups took 4 weeks as a course of treatment, a total of 2 courses of treatment. Total clinical effective rate, traditional Chinese medicine syndrome score, serum inflammatory factors and CREB signal transduction pathway related protein expression levels were compared between the two groups. Results: The total clinical effective rate of the observation was higher than that of the control group(P<0.05). After treatment, the total score of main syndrome and secondary syndrome of TCM Syndrome, serum interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), C-reactive protein (CRP) levels and the CREB microRNA (mRNA), PKAmRNA and p38mRNA expression levels decreased compared with those before treatment, and the observation group was lower than that of the control group(P<0.05). Conclusion: Jiedu Huayu decoction combined with blood letting puncture therapy in the treatment of patients with psoriasis vulgaris of blood stasis heat syndrome has a significant effect, which can effectively improve clinical symptoms, and reduce the body's inflammatory response. The main mechanism of action may be related to the regulation of CREB signal transduction pathway related protein expression. |
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