| 高 洁,王 霞,方 舒,燕建锋,姚 娟.心房颤动血清Lp-PLA2、BNP与疾病严重程度相关性分析[J].,2023,(3):479-482 |
| 心房颤动血清Lp-PLA2、BNP与疾病严重程度相关性分析 |
| Association Analysis of AF Serum Lp-PLA2 and BNP and Disease Severity |
| 投稿时间：2022-05-06 修订日期：2022-05-30 |
| DOI：10.13241/j.cnki.pmb.2023.03.016 |
| 中文关键词: 心房颤动 血清Lp-PLA2 BNP 疾病严重程度 |
| 英文关键词: Atrial fibrillation Serum Lp-PLA2 BNP Disease severity |
| 基金项目:新疆维吾尔自治区科学技术厅科技援疆计划项目（2021E02076） |
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| 中文摘要: |
| 摘要 目的：分析心房颤动血清脂蛋白磷脂酶（A2Lp-PLA2）、脑钠肽（BNP）与疾病严重程度相关性分析，进而为此类疾病诊疗提供参考。方法：以本院住院诊疗的110例心血管疾病患者为主体，控制研究时间为2018年8月-2021年8月，全部患者诊疗资料均保存完整且根据有无房颤分为房颤组、无房颤组，各组均有55例。检测全部患者血清Lp-PLA2、BNP水平，同时实施超声心动图、心电图检查。结果：无房颤组血清Lp-PLA2、BNP水平显著较房颤组低，（P＜0.05）；无房颤组LVEDD、LAD水平明显高于房颤组，LVEF、E/A明显低于房颤组，（P＜0.05）；无房颤组患者中，心功能Ⅱ级、Ⅲ级、Ⅳ级患者的血清Lp-PLA2、BNP均明显低于房颤组中心功能Ⅱ级、Ⅲ级、Ⅳ级的患者，（P＜0.05）；血清Lp-PLA2与LVEDD呈负相关（r=-0.867，P＜0.05），与LAD呈负相关（-0.609，P＜0.05），与LVEF呈正相关（r=0.657，P＜0.05），与E/A呈正相关（r=0.785，P＜0.05），与心功能等级呈正相关（r=0.759，P＜0.05）；BNP与LVEDD呈负相关（r=-0.769，P＜0.05），与LAD呈负相关（-0.701，P＜0.05），与LVEF呈正相关（r=0.645，P＜0.05），与E/A呈正相关（r=0.724，P＜0.05），与心功能等级呈正相关（r=0.729，P＜0.05）。结论：血清Lp-PLA2、BNP水平与心房颤动患者疾病严重程度密切相关，血清Lp-PLA2、BNP、心脏功能指标均参与了疾病的病理生理过程，其中血清Lp-PLA2和BNP与LVEF、E/A呈正相关，与LAD、LVEDD呈负相关，故临床认为血清Lp-PLA2、BNP是预测心房颤动患者风险程度的敏感指标，通过检测该指标水平，可了解机体心功能情况，有利于早期诊断疾病及评估病情发展情况。 |
| 英文摘要: |
| ABSTRACT Objective: The correlation of serum lipoprotein phosphaipase (A2Lp-PLA2) and brain sodium peptide (BNP) and disease severity was analyzed, so as to provide reference for the diagnosis and treatment of such diseases. Methods: A total of 110 patients with cardiovascular disease who were hospitalized in our hospital were used as the main body. The control study period was from August 2018 to August 2021. All patients' diagnosis and treatment data were kept intact and were divided into atrial fibrillation group, atrial fibrillation group, and atrial fibrillation group according to their presence or absence. There were 55 cases in each group without atrial fibrillation. Serum levels of Lp-PLA2 and BNP were detected in all patients, and echocardiography and electrocardiography were performed at the same time. Results: The levels of serum Lp-PLA2 and BNP in the non-AF group were significantly lower than those in the AF group, (P<0.05); the levels of LVEDD and LAD in the non-AF group were significantly higher than those in the AF group, and LVEF and E/A were significantly lower than those in the AF group(P<0.05); in the patients without atrial fibrillation, the serum Lp-PLA2 and BNP of patients with cardiac function grades II, III and IV were significantly lower than those in the atrial fibrillation group of patients with cardiac function grades II, III and IV(P<0.05); Serum Lp-PLA2 was negatively correlated with LVEDD (r=-0.867, P＜0.05), negatively correlated with LAD (-0.609, P＜0.05), and positively correlated with LVEF (r=0.657, P＜0.05) ), was positively correlated with E/A (r=0.785, P＜0.05), positively correlated with cardiac function grade (r=0.759, P＜0.05); BNP was negatively correlated with LVEDD (r=-0.769, P＜0.05) , negatively correlated with LAD (-0.701, P＜0.05), positively correlated with LVEF (r=0.645, P＜0.05), positively correlated with E/A (r=0.724, P＜0.05), and positively correlated with cardiac function grade Correlation (r=0.729, P<0.05). Conclusion: The levels of serum Lp-PLA2 and BNP are closely related to the severity of the disease in patients with atrial fibrillation. Serum Lp-PLA2, BNP and cardiac function indexes are all involved in the pathophysiological process of the disease. Among them, serum Lp-PLA2 and BNP are closely related to LVEF, E/ A is positively correlated with LAD and LVEDD, so it is clinically believed that serum Lp-PLA2 and BNP are sensitive indicators for predicting the risk level of patients with atrial fibrillation. By detecting the level of this indicator, we can understand the body's cardiac function, which is conducive to early diagnosis of the disease and assess the progression of the disease. |
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