| 梁金才,李秉倩,朱健华,林宇驰,蒋 平.芪明颗粒联合玻璃酸钠滴眼液治疗儿童中度干眼症的疗效及对泪液氧化应激和炎症因子的影响[J].,2023,(1):168-171 |
| 芪明颗粒联合玻璃酸钠滴眼液治疗儿童中度干眼症的疗效及对泪液氧化应激和炎症因子的影响 |
| Qiming Granule Combined with Sodium Hyaluronate Eye Drops in the Treatment of Moderate Dry Eye in Children and its Effect on Tear Oxidative Stress and Inflammatory Factors |
| 投稿时间：2022-03-28 修订日期：2022-04-23 |
| DOI：10.13241/j.cnki.pmb.2023.01.033 |
| 中文关键词: 中度干眼症 儿童 芪明颗粒 玻璃酸钠滴眼液 疗效 氧化应激 炎症因子 |
| 英文关键词: Moderate dry eye Children Qiming granule Sodium hyaluronate eye drops Efficacy Oxidative stress Inflammatory factors |
| 基金项目:贵州省科技计划项目（黔科合LH字[2014]7301号） |
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| 中文摘要: |
| 摘要 目的：探讨芪明颗粒联合玻璃酸钠滴眼液治疗儿童中度干眼症的疗效及对泪液氧化应激和炎症因子的影响。方法：选取2019年8月~2021年12月期间来贵阳市妇幼保健院就诊的干眼症患儿，共计90例。入选的患儿根据随机数字表法分为对照组（玻璃酸钠滴眼液治疗）和观察组（芪明颗粒联合玻璃酸钠滴眼液治疗），各为45例，两组均治疗3个月。对比两组疗效、临床指标、泪液氧化应激指标、炎症因子指标和不良反应。结果：观察组93.33%的临床总有效率较对照组68.89%高，差异有统计学意义（P<0.05）。两组不良反应发生率对比无差异（P>0.05）。观察组治疗3个月后泪膜破裂时间（BUT）、泪液分泌试验（SIT）较对照组高，角膜荧光染色（FL）评分较对照组低（P<0.05）。观察组治疗3个月后超氧化物歧化酶（SOD）高于对照组，丙二醛（MDA）、过氧化脂质（LPO）低于对照组（P<0.05）。观察组治疗3个月后白细胞介素1β（IL-1β）、白介素-6（IL-6）、超敏C反应蛋白（hs-CRP）、白介素-8（IL-8）低于对照组（P<0.05）。结论：儿童中度干眼症采用玻璃酸钠滴眼液联合芪明颗粒治疗，可有效降低患儿的氧化应激和炎症反应，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of Qiming granule combined with sodium hyaluronate eye drops in the treatment of moderate dry eye in children and its effects on tear oxidative stress and inflammatory factors. Methods: A total of 90 patients with dry eye who came to Guiyang Maternal and Child Health Hospital from August 2019 to December 2021 were selected. The selected children were divided into control group (sodium hyaluronate eye drops treatment) and observation group (Qiming granule combined with sodium hyaluronate eye drops treatment) according to random number table method, with 45 cases in each group. Both groups were treated for 3 months. The efficacy, clinical indexes, tear oxidative stress indexes, inflammatory factor indexes and adverse reactions were compared between the two groups. Results: The total clinical effective rate of 93.33% in the observation group was higher than 68.89% in the control group, the difference was statistically significant(P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). 3 months after treatment, the tear film break-up time (BUT) and Schirmer I test (SIT) in the observation group were higher than those in the control group, and the corneal fluorescence staining (FL) score was lower than that in the control group (P<0.05). 3 months after treatment, superoxide dismutase (SOD) in the observation group was higher than that in the control group, while malondialdehyde (MDA) and lipid peroxide (LPO) were lower than those in the control group (P<0.05). Interleukin 1β (IL-1β), interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP) and interleukin-8 (IL-8) in the observation group were lower than those in the control group 3 months after treatment(P<0.05). Conclusion: Children with moderate dry eye are treated with sodium hyaluronate eye drops combined with Qiming granule, it can effectively reduce the oxidative stress and inflammatory reaction in children, and it is safe. |
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