| 唐 南,席春华,张玲玲,张婷婷,刘晓婷.天丹通络胶囊联合丁苯酞软胶囊治疗急性脑梗死的疗效及对炎症因子和脑血流动力学的影响[J].,2023,(1):142-145 |
| 天丹通络胶囊联合丁苯酞软胶囊治疗急性脑梗死的疗效及对炎症因子和脑血流动力学的影响 |
| Efficacy of Tiandan Tongluo Capsule Combined with Butylphthalide Soft Capsule on Acute Cerebral Infarction and its Effect on Inflammatory Factors and Cerebral Hemodynamics |
| 投稿时间：2022-04-30 修订日期：2022-05-24 |
| DOI：10.13241/j.cnki.pmb.2023.01.028 |
| 中文关键词: 天丹通络胶囊 丁苯酞软胶囊 急性脑梗死 疗效 炎症因子 脑血流动力学 |
| 英文关键词: Tiandan Tongluo capsule Butylphthalide soft capsule Acute cerebral infarction Efficacy Inflammatory factors Cereral hemodynamics |
| 基金项目:安徽省重点研究与开发计划立项项目（202004j07020006） |
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| 中文摘要: |
| 摘要 目的：探讨天丹通络胶囊联合丁苯酞软胶囊治疗急性脑梗死（ACI）的疗效及对炎症因子和脑血流动力学的影响。方法：按照随机数字表法将合肥市第一人民医院2019年1月-2021年12月间接收的100例ACI患者分为对照组（50例，丁苯酞软胶囊治疗）和观察组（50例，天丹通络胶囊联合丁苯酞软胶囊治疗）。对比两组疗效、量表评分、炎症因子和脑血流动力学，统计两组治疗期间不良反应发生率。结果：观察组84.00%的临床总有效率高于对照组66.00%（P<0.05）。与对照组比较，治疗后观察组Barthel指数评分升高，美国国立卫生研究院卒中量表（NIHSS）评分降低（P<0.05）。观察组治疗后的白介素-6（IL-6）、超敏C反应蛋白（hs-CRP）低于对照组，白介素-10（IL-10）高于对照组（P<0.05）。观察组治疗后的阻力指数（RI）低于对照组，脑血流收缩期峰值血流速度（Vs）、平均血流速度（Vm）、舒张期血流速度（Vd）较对照组高（P<0.05）。不良反应发生率组间对比无差异（P>0.05）。结论：天丹通络胶囊联合丁苯酞软胶囊有助于降低ACI患者的炎症因子水平，改善脑血流动力学，效果显著。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of Tiandan Tongluo capsule combined with butylphthalide soft capsule in the treatment of acute cerebral infarction (ACI) and its effects on inflammatory factors and cerebral hemodynamics. Methods: According to the random number table method, 100 patients with ACI who were received in Hefei First People's Hospital from January 2019 to December 2021 were divided into control group (50 cases, treated with butylphthalide soft capsule) and observation group (50 cases, treated with Tiandan Tongluo capsule combined with butylphthalide soft capsule). The efficacy, scale score, inflammatory factors and cerebral hemodynamics in the two groups were compared, and the incidence of adverse reactions during treatment in the two groups was counted. Results: The total clinical effective rate in the observation group was 84.00% higher than 66.00% in the control group (P<0.05). Compared with the control group, after treatment, the Barthel index score in the observation group increased, and the score of national Institutes of Health Stroke Scale (NIHSS) decreased (P<0.05). After treatment, interleukin-6 (IL-6) and hypersensitive C-reactive protein (hs-CRP) in the observation group were lower than those in the control group, and interleukin-10 (IL-10) was higher than that in the control group (P<0.05). After treatment, the resistance index (RI) in the observation group was lower than that in the control group, and the peak systolic blood flow velocity (Vs), mean blood flow velocity (Vm) and diastolic blood flow velocity (Vd) were higher than those in the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Tiandan Tongluo capsule combined with butylphthalide soft capsule can reduce the levels of inflammatory factors and improve cerebral hemodynamics in patients with ACI, the effect is remarkable. |
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