| 沈晓丽,殷一飞,袁翠平,栾 炜,尹剑兵.血清抑制素-A表达联合经腹部超声对宫外孕的诊断价值分析[J].,2023,(1):68-72 |
| 血清抑制素-A表达联合经腹部超声对宫外孕的诊断价值分析 |
| Diagnostic Value of Serum INH-A Expression Combined with Transabdominal Ultrasound in Ectopic Pregnancy |
| 投稿时间：2022-02-28 修订日期：2022-03-23 |
| DOI：10.13241/j.cnki.pmb.2023.01.013 |
| 中文关键词: 血清抑制素-A 经腹部超声 宫外孕 诊断价值 诊断准确率 |
| 英文关键词: Serum INH-A Transabdominal ultrasound Ectopic pregnancy Diagnostic value Diagnostic accuracy |
| 基金项目:国家自然科学基金项目（81704196） |
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| 中文摘要: |
| 摘要 目的：探讨血清抑制素-A表达联合经腹部超声对宫外孕的诊断价值。方法：选取我院2018年1月到2021年8月共收治的60例宫外孕患者作为研究对象，将其分为观察组，另取同期来我院体检的60例正常妊娠孕妇作为对照组，对所有孕妇均行血清抑制素-A（INH-A）、碱性磷酸酶（ALP）、β-人绒毛膜促性腺激素（β-HCG）检测，并对所有孕妇进行经腹部超声诊断。对比两组患者血清中ALP、β-HCG与INH-A表达水平，对比两组孕妇经腹部超声诊断结果，分析两组孕妇血清INH-A和经腹部超声单一诊断与联合诊断对宫外孕的诊断价值。结果：观察组孕妇ALP、β-HCG水平明显低于对照组，INH-A水平明显高于对照组（P＜0.05）；观察组孕妇无胎心搏动、宫内无孕囊、附件区有包块以及子宫内膜厚度小于10 mm情况明显高于对照组（P＜0.05）；联合诊断检出率明显高于血清抑INH-A和经腹部超声（P＜0.05），联合诊断的误诊率和漏诊率明显低于血清INH-A和经腹部超声（P＜0.05）；联合诊断的准确度、敏感度明显高于其他两组单一检查方法（P＜0.05），三种诊断方法在特异度、阳性预测值和阴性预测值方面的检测价值对比并无显著差异（P＞0.05）。结论：应用血清抑制素-A表达联合经腹部超声诊断可提升宫外孕诊断的准确度与敏感性，因此可考虑对临床症状疑似宫外孕的患者应用两者联合诊断，提升诊断准确率。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the diagnostic value of serum INH-A expression combined with transabdominal ultrasound in ectopic pregnancy. Methods: 60 patients with ectopic pregnancy treated in our hospital from January 2018 to August 2021 were selected as the research object and divided into the observation group. Another 60 normal pregnant women who came to our hospital for physical examination in the same period were selected as the control group. All pregnant women were treated with serum inhibin-A (inh-a), alkaline phosphatase (ALP) β-Human chorionic gonadotropin (β-All pregnant women were diagnosed by transabdominal ultrasound. The expression levels of ALP, β-HCG and INH-A in serum of the two groups were compared, and the diagnostic results of transabdominal ultrasound were compared between the two groups. The diagnostic value of single diagnosis and combined diagnosis of serum INH-A and transabdominal ultrasound in ectopic pregnancy of the two groups were analyzed. Results: ALP of pregnant women in the observation group β- The level of hCG was lower than that of the control group, and the level of INH-A was higher than that of the control group (P<0.05). In the observation group, the incidence of no fetal heart beat, no intrauterine pregnancy sac, adnexal mass and endometrial thickness less than 10 mm were higher than those in the control group (P<0.05). By comparing the detection rate of ectopic pregnancy in 72 patients, it was found that the detection rate of combined diagnosis was significantly higher than that of serum INH-A and transabdominal ultrasound, and the misdiagnosis rate and missed diagnosis rate of combined diagnosis were lower than that of serum INH-A and transabdominal ultrasound (P<0.05); By comparing the detection value of different tests, it was found that the accuracy and sensitivity of combined diagnosis were significantly higher than those of the other two single test methods (P<0.05), and there was no difference in the detection value of specificity, positive predictive value and negative predictive value among the three diagnostic methods (P>0.05). Conclusion: The application of serum INH-A expression combined with transabdominal ultrasound diagnosis can improve the accuracy and sensitivity of ectopic pregnancy diagnosis, so it can be considered for patients with suspected clinical symptoms of ectopic pregnancy to apply the combined diagnosis, improve the diagnostic accuracy. |
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