| 华 佳,张 悦,李瑞雪,刘 斌,王 凉.血清klotho、FGF水平与腹膜透析患者颈动脉粥样硬化的相关性[J].,2022,(24):4705-4709 |
| 血清klotho、FGF水平与腹膜透析患者颈动脉粥样硬化的相关性 |
| Correlation between Serum Klotho, FGF Levels and Carotid Atherosclerosis in Patients with Peritoneal Dialysis |
| 投稿时间：2022-03-05 修订日期：2022-03-31 |
| DOI：10.13241/j.cnki.pmb.2022.24.020 |
| 中文关键词: 腹膜透析 颈动脉粥样硬化 血清klotho 成纤维细胞生长因子 相关性 |
| 英文关键词: Peritoneal dialysis Carotid atherosclerosis Serum klotho Fibroblast growth factor Correlation |
| 基金项目:无锡市卫生健康委科技成果与适宜技术推广项目（T202038） |
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| 中文摘要: |
| 摘要 目的：观察腹膜透析患者颈动脉粥样硬化（As）情况及血清klotho、成纤维细胞生长因子（FGF）的表达，分析血清klotho、FGF表达与腹膜透析患者颈动脉As的关系。方法：选取我院2016年12月-2017年10月接受腹膜透析治疗的154例患者作为研究对象，统计颈动脉As发生情况，检测血清klotho、FGF水平。结果：154例腹膜透析患者患者中，颈动脉As发生率为51.16 %；发生颈动脉As患者的血清klotho水平低于未发生患者，血清FGF水平高于未发生患者，差异有统计学意义（P＜0.05）；采用双变量Pearson直线相关性分析发现，腹膜透析患者血清klotho水平与FGF水平呈负相关（r＜0，P＜0.001）；经多项Logistic回归分析结果显示，血清klotho低表达、血清FGF过表达均是腹膜透析患者发生颈动脉As的影响因素（OR＞1，P＜0.05）； ROC曲线结果显示，血清klotho、FGF预测腹膜透析患者发生颈动脉As风险的AUC均＞0.80。结论：腹膜透析患者颈动脉As的发生可能与血清klotho低表达、血清FGF过表达有关，建议临床通过检测患者血清klotho、FGF水平，预测颈动脉As发生风险。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the carotid atherosclerosis (As) and the expression of serum klotho and fibroblast growth factor (FGF) in patients with peritoneal dialysis, to analyze the relationship between serum klotho, FGF expression and carotid As in patients with peritoneal dialysis. Methods: A total of 154 patients who received peritoneal dialysis in our hospital from December 2016 to October 2017 were involved in this study. The occurrence of As in the carotid artery was counted, and the serum levels of klotho and FGF were detected. Results: The incidence of carotid As was 51.16 % (78/154). The serum klotho level of patients who occurred carotid As was lower than that of non-occurring carotid As patients, and the serum FGF level was higher than that of non-occurring patients, the difference was significant statistically (P<0.05); the bivariate Pearson linear correlation analysis was used and found that serum klotho levels in patients with peritoneal dialysis were negatively correlated with FGF levels (r<0, P<0.001); the results of multiple logistic regression analysis showed that the low expression of serum klotho and the overexpression of serum FGF were the influencing factors of carotid As in patients with peritoneal dialysis (OR>1, P<0.05); the ROC curve showed that the AUC of serum klotho and FGF predicting the risk of carotid As in patients with peritoneal dialysis were both>0.80, and the predictive value was ideal. Conclusion: The occurrence of carotid As in patients with peritoneal dialysis may be related to the low expression of serum klotho and the overexpression of serum FGF. Clinically, the risk of carotid As can be predicted by detecting the serum klotho and FGF levels of patients. |
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