| 杨 澜,吴夏楠,刘 冲,和 婷,董 轲,郜赵伟.血清CD5L对肝脏疾病患者的临床意义研究[J].,2022,(24):4663-4668 |
| 血清CD5L对肝脏疾病患者的临床意义研究 |
| Clinical Significance of Serum CD5L in Patients with Liver Disease |
| 投稿时间：2022-05-31 修订日期：2022-06-28 |
| DOI：10.13241/j.cnki.pmb.2022.24.012 |
| 中文关键词: CD5L 肝纤维化 肝病 诊断 |
| 英文关键词: CD5L Liver fibrosis Liver disease Diagnosis |
| 基金项目:国家自然科学基金项目（81702732）；唐都医院人才基金资助项目（2021SHRC042） |
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| 中文摘要: |
| 摘要 目的：检测CD5L水平在肝脏疾病患者血清中的变化，并分析其临床意义。方法：采用ELISA法检测41例慢性肝炎患者、192例肝硬化患者、69例肝癌患者和136例健康对照血清CD5L水平。全自动生化分析仪测定肝功能指标，Spearman相关性分析用于评估CD5L与肝功能指标的关系。受试者工作曲线（receiver operator characteristic, ROC）分析血清CD5L的潜在诊断价值。结果：与健康对照相比，CD5L水平在肝炎、肝硬化、肝癌患者中显著降低（P<0.01）。肝硬化患者血清CD5L水平较肝炎及肝癌患者显著降低（P<0.01）。肝硬化代偿期和失代偿期患者血清CD5L水平无显著差异。血清CD5L水平与FIB-4指数(肝纤维化评分)呈显著负相关（r=-0.2688，P=0.0001）。Spearman相关性分析结果显示：在肝炎患者中，血清CD5L与总胆红素（T-BIL）、直接胆红素（D-BIL）、间接胆红素（I-BIL）显著正相关；在肝硬化患者中，CD5L与其他肝功指标无显著相关性；在肝癌患者中，CD5L与碱性磷酸酶（ALP）显著正相关。以健康人为对照组，肝硬化患者为病例组，ROC分析显示血清CD5L的诊断特异性为85.3%，敏感性为77.1%。结论：CD5L水平在肝炎、肝硬化及肝癌患者血清中显著降低，且在肝硬化患者中最低。CD5L水平与肝纤维化评分FIB-4指数负相关，可作为监测肝纤维化进展的潜在生物标志物。 |
| 英文摘要: |
| ABSTRACT Objective: To detect the CD5L levels in serum from patients with liver disease and to explore its protential clinical significance. Methods: 41 patients with chronic hepatitis, 192 patients with liver cirrhosis, 69 patients with liver cancer and 136 healthy controls were included in this study. Serum CD5L levels were detected by ELISA assay. Automatic biochemical analyzer was used to measure liver function indexes. Spearman correlation analysis was used to evaluate the relationship between serum CD5L levels and liver function indexes. Receiver operator characteristic (ROC) curve analysis was used to evaluate the potential diagnostic value of serum CD5L levels. Results: Compared with healthy controls, CD5L levels were significant decreased in patients with hepatitis, cirrhosis and hepatocellular carcinoma (P<0.01). The serum CD5L levels in patients with cirrhosis was significant lower than that in patients with hepatitis or hepatocellular carcinoma (P<0.01). There was no significant difference for serum CD5L level between patients with decompensated liver cirrhosis and compensatory liver cirrhosis. Serum CD5L level was negatively correlated with FIB-4 index (r=-0.2688, P=0.0001). Spearman correlation analysis showed that there was a significant positive correlation between serum CD5L with total bilirubin (T-BIL), direct bilirubin (D-BIL) and indirect bilirubin (I-BIL) in hepatitis patients. There was no significant correlation between CD5L and other liver function indexes in patients with cirrhosis. CD5L was significant positively correlated with alkaline phosphatase (ALP) in patients with liver cancer. The ROC analysis showed that the diagnostic specificity and sensitivity of serum CD5L were 85.3% and 77.1%. Conclusion: CD5L levels were significant decreased in serum form patients with liver injury, and were the lowest in patients with cirrhosis. CD5L might be a potential biomarker for monitoring liver fibrosis progression. |
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