文章摘要
严家妮,杨 梅,张 航,张如平,刘 蕊,张 洋.血清PTH及肿瘤标志物在类风湿关节炎患者合并骨质疏松症诊断价值分析[J].,2022,(23):4560-4564
血清PTH及肿瘤标志物在类风湿关节炎患者合并骨质疏松症诊断价值分析
Analysis of the Diagnostic Value of Serum PTH and Tumor Markers in Patients with Rheumatoid Arthritis Complicated with Osteoporosis
投稿时间:2022-03-19  修订日期:2022-04-15
DOI:10.13241/j.cnki.pmb.2022.23.032
中文关键词: 甲状腺旁激素  肿瘤标志物  类风湿性关节炎  骨质疏松症
英文关键词: Parathyroid hormone  Tumor markers  Rheumatoid arthritis  Osteoporosis
基金项目:贵州省卫生计生委科学技术基金项目(gzwjkj2017-1-064)
作者单位E-mail
严家妮 贵州中医药大学第二附属医院检验科 贵州 贵阳 550001 yanjiani8586@163.com 
杨 梅 贵州中医药大学第二附属医院检验科 贵州 贵阳 550001  
张 航 贵州中医药大学第二附属医院检验科 贵州 贵阳 550001  
张如平 贵州中医药大学第二附属医院检验科 贵州 贵阳 550001  
刘 蕊 贵州中医药大学第二附属医院中心实验室 贵州 贵阳 550001  
张 洋 贵州中医药大学第二附属医院检验科 贵州 贵阳 550001  
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中文摘要:
      摘要 目的:研究血清甲状旁腺激素(PTH)和肿瘤标志物对类风湿性关节炎合并骨质疏松症(RAOP)的诊断价值。方法:选取2019年1月-2021年12月在我院就诊的60例RAOP患者为研究对象,并选取同期在我院就诊的类风湿性关节炎(RA)患者作为对照。比较两组患者血清PTH、甲胎蛋白(AFP)、癌胚抗原(CEA)、癌抗原125(CA125)、癌抗原199(CA199)和癌抗原724(CA724)。通过pearsonr相关系数分析各指标的相关性,通过Logistic回归分析RAOP的影响因素和通过受试者工作特征(ROC)曲线分析各指标对RAOP的诊断价值。结果:(1)RAOP患者血清PTH、CA125和CA199水平均显著高于RA患者(P<0.05),而血清CA724水平显著低于RA患者(P<0.05),并且血清AFP和CEA水平与RA患者比较无差异(P>0.05);(2)RAOP患者血清PTH与血清PTH水平与血清CA125和CA199水平呈正相关(P<0.05),与血清CA724水平呈负相关(P<0.05),与血清AFP和CEA水平不相关(P>0.05);(3)Logistic回归分析显示:血清PTH、CA125、CA199、CA724是影响类风湿性关节炎合并骨质疏松症的独立影响因素(P<0.05);(4)ROC曲线分析显示:血清PTH、CA125、CA199对RAOP具有诊断价值,诊断敏感性和特异性分别为90.00%和86.97%、80.36 %和78.97 %、75.62 %和75.12 %。结论:血清PTH、CA125和CA199在RAOP患者含量升高,是影响RAOP的独立危险因素,可作为诊断RAOP的指标。
英文摘要:
      ABSTRACT Objective: To explore the application effect of da Vinci robot in elderly abdominal surgery under general anesthesia. Methods: A total of 60 RAOP patients who were treated in our hospital from January 2019 to December 2021 were selected as the research objects, and rheumatoid arthritis (RA) patients who were treated in our hospital during the same period were selected as controls. The serum levels of PTH, alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cancer antigen 199 (CA199) and cancer antigen 724 (CA724) were compared between the two groups. The correlation of each index was analyzed by pearsonr correlation coefficient, the influencing factors of RAOP were analyzed by Logistic regression, and the diagnostic value of each index for RAOP was analyzed by receiver operating characteristic(ROC) curve. Results: (1) Serum levels of PTH, CA125 and CA199 in RAOP patients were higher than those in RA patients (P<0.05), while serum CA724 levels were lower than those in RA patients(P<0.05), and serum AFP and CEA levels were not compared with those in RA patients. (P>0.05); (2) Serum PTH and serum PTH levels in RAOP patients were positively correlated with serum CA125 and CA199 levels (P<0.05), negatively correlated with serum CA724 levels (P<0.05), and serum AFP and CEA levels(P>0.05); (3) Logistic regression analysis showed that serum PTH, CA125, CA199, CA724 were independent influencing factors for rheumatoid arthritis complicated with osteoporosis (P<0.05); (4) ROC curve analysis showed that serum PTH, CA125, and CA199 had diagnostic value for RAOP, and the diagnostic sensitivity and specificity were 90.00 % and 86.97 %, 80.36 % and 78.97 %, 75.62 % and 75.12 %, respectively. Conclusion: Serum PTH, CA125 and CA199 levels are elevated in patients with RAOP, which are independent risk factors for RAOP and can be used as indicators for the diagnosis of RAOP.
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