| 徐丙怡,巩尊科,王世雁,王 翔,马喆喆.高频重复经颅磁刺激联合言语听觉反馈训练对脑卒中后认知功能障碍患者事件相关电位P300和血清NSE、S100β蛋白的影响[J].,2022,(23):4541-4545 |
| 高频重复经颅磁刺激联合言语听觉反馈训练对脑卒中后认知功能障碍患者事件相关电位P300和血清NSE、S100β蛋白的影响 |
| Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation Combined with Speech-Auditory Feedback Training on Event-Related Potential P300 and Serum NSE and S100β Protein in Patients with Post-Stroke Cognitive Impairment |
| 投稿时间：2022-04-23 修订日期：2022-05-17 |
| DOI：10.13241/j.cnki.pmb.2022.23.028 |
| 中文关键词: 高频重复经颅磁刺激 言语听觉反馈训练 脑卒中后认知功能障碍 事件相关电位P300 NSE S100β蛋白 |
| 英文关键词: High-frequency repetitive transcranial magnetic stimulation Speech-auditory feedback training Post stroke cognitive impairment Event-related potential P300 NSE S100β protein |
| 基金项目:江苏省卫生健康委员会（K2019012）；徐州市科技局计划项目（KC19156） |
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| 中文摘要: |
| 摘要 目的：探讨高频重复经颅磁刺激（rTMS）联合言语听觉反馈训练对脑卒中后认知功能障碍（PSCI）患者认知功能的改善作用及对事件相关电位P300和血清神经元特异性烯醇化酶（NSE）、S100β蛋白的影响。方法：研究对象来源于徐州市中心医院2020年3月~2022年2月期间收治的130例PSCI患者。根据随机数字表法将患者分为对照组（n=65）和实验组（n=65），对照组患者接受常规治疗方案和言语听觉反馈训练，实验组在对照组的基础上联合高频rTMS。对比两组干预8周后认知功能、生活质量、事件相关电位P300和血清NSE、S100β蛋白的变化情况。结果：干预8周后，两组蒙特利尔认知评估量表（MoCA）、Rivermead行为记忆测验（RBMT）升高，且实验组高于对照组（P<0.05）；干预8周后，两组维多利亚版Stroop测试（VST）下降，且实验组低于对照组（P<0.05）。干预8周后，两组改良的Barthel指数（MBI）、日常生活能力量表（ADL）评分升高，且实验组高于对照组（P<0.05）。干预8周后，两组波幅升高，且实验组高于对照组（P<0.05）；干预8周后，两组潜伏期下降，且实验组低于对照组（P<0.05）。干预8周后，两组血清NSE、S100β蛋白水平下降，且实验组低于对照组（P<0.05）。结论：高频rTMS联合言语听觉反馈训练可有效改善PSCI患者的认知功能，同时还可调节事件相关电位P300和血清NSE、S100β蛋白水平，提高患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) combined with speech-auditory feedback training on the cognitive function improvement in patients with post-stroke cognitive impairment (PSCI) and the effects of event-related potential P300 and serum neuron specific enolase (NSE) and S100β protein. Methods: The subjects were recruited from 130 patients with who were PSCI admitted to Xuzhou Central Hospital from March 2020 to February 2022. Patients were divided into control group(n=65) and experimental group (n=65) according to random number table method. Patients in the control group received conventional treatment plan and speech-auditory feedback training, and the experimental group was combined with high-frequency rTMS on the basis of the control group. The changes of cognitive function, quality of life, event-related potential P300 and serum NSE and S100β protein were compared between the two groups at 8 weeks after intervention. Results: 8 weeks after intervention, Montreal Cognitive Assessment Scale (MoCA) and Rivermead behavioral Memory Test (RBMT) increased in two groups, and the experimental group was higher than the control group (P<0.05). 8 weeks after intervention, Victoria Stroop test (VST) decreased in two groups, and the experimental group was lower than the control group(P<0.05). 8 weeks after intervention, the modified Barthel index(MBI) and Activity of Daily Living Scale (ADL) scores in two groups increased, and the experimental group was higher than the control group (P<0.05). 8 weeks after intervention, the amplitude in the two groups increased, and the experimental group was higher than the control group(P<0.05), 8 weeks after intervention, the latency in the two groups decreased, and the experimental group was lower than the control group(P<0.05). 8 weeks after intervention, the levels of serum NSE and S100β protein in two groups decreased, and the experimental group was lower than the control group(P<0.05). Conclusion: High-frequency rTMS combined with speech-auditory feedback training can effectively improve the cognitive function of patients with PSCI, and also regulate the level of event-related potential P300 and serum NSE and S100β protein, and improve the quality of life of patients. |
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