| 李二雷,刘冬梅,安国倩,邓宏文,丁 圆.抗HPV生物凝胶敷料辅助保妇康栓治疗HPV感染性宫颈炎的临床意义[J].,2022,(23):4516-4520 |
| 抗HPV生物凝胶敷料辅助保妇康栓治疗HPV感染性宫颈炎的临床意义 |
| Clinical Significance of Anti-HPV Biogel Dressing Assisted by Baofukang Suppository in the Treatment of HPV-infected Cervicitis |
| 投稿时间：2022-04-08 修订日期：2022-04-30 |
| DOI：10.13241/j.cnki.pmb.2022.23.023 |
| 中文关键词: 人乳头瘤病毒 生物凝胶 保妇康栓 宫颈炎 |
| 英文关键词: Human papillomavirus Biogel Baofukang suppository Cervicitis |
| 基金项目:河北省医学科学研究项目（20210329） |
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| 中文摘要: |
| 摘要 目的：探讨抗人乳头瘤病毒（HPV）生物凝胶敷料辅助保妇康栓治疗HPV感染性宫颈炎的临床意义。方法：选择2020年1月至2022年1月在本院接受治疗的HPV感染性宫颈炎患者90例作为研究对象，根据1:1简单分配法把患者分为生物凝胶组与对照组各45例。对照组给予保妇康栓治疗，生物凝胶组在对照组治疗的基础上给予抗HPV生物凝胶敷料治疗，两组都治疗观察1个月。结果：生物凝胶组治疗后的总有效率为100.0 %，高于对照组的86.7 %（P<0.05）。生物凝胶组治疗后HPV转阴率为80.0 %，高于对照组的62.2 %（P<0.05）。治疗后生物凝胶组的的血清白介素-6（IL-6）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）含量低于治疗前，生物凝胶组低于对照组（P<0.05）。生物凝胶组治疗期间的恶心呕吐、发热、睡眠障碍、乏力等不良反应发生率为6.7 %，低于对照组的28.9 %（P<0.05）。治疗后生物凝胶组生活质量评分高于对照组（P<0.05）。结论：抗HPV生物凝胶敷料辅助保妇康栓治疗HPV感染性宫颈炎有效提升患者的治疗效果及HPV转移率，减少不良反应的发生，可抑制炎症因子的表达，从而持续改善患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical significance of anti-human papillomavirus (HPV) biogel dressing assisted by Baofukang suppository in the treatment of HPV-infected cervicitis. Methods: From January 2020 to January 2022, A total of 90 patients with HPV-infected cervicitis who were treated in our hospital were selected as the research subjects. All the cases were divided into the biogel group and the matched group with 45 cases each groups accorded to the 1:1 simple allocation method. The matched group were treated with Baofukang suppository, and the biogel group were treated with anti-HPV biogel dressing based on the treatment of the matched group. Both groups were treated and observed for 1 month. Results: The total effective rates post-treatment in the biogel group were 100.0 %, which were higher than 86.7 % in the matched group(P<0.05). The negative rate of HPV post-treatment in the biogel group were 80.0 %, which were higher than 62.2 % in the matched group(P<0.05). post-treatment, the serum levels of interleukin-6 (IL-6), C reactive protein (CRP), and tumor necrosis factor-α (TNF-α) in the biogel group were lower than Before treatment (P<0.05), the biogel group was lower than the matched group(P<0.05). The incidence rates of adverse reactions such as nausea and vomiting, fever, sleep disturbance, and fatigue in the biogel group during treatment were 6.7 %, which were lower than 28.9 % in the matched group (P<0.05). Post-treatment, the quality of life scores of the biogel group were higher than those of the matched group (P<0.05). Conclusion: Anti-HPV bio-gel dressing assisted Baofukang suppository in the treatment of HPV-infected cervicitis can effectively improve the treatment effect and HPV transfer rate of patients, reduce adverse reactions, it can can inhibit the expression of inflammatory factors, and continuously improve the quality of life of patients. |
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