文章摘要
何海燕,岳 娟,周 麟,宋 琪,李 荣.氧化应激指标与子宫内膜异位症的关系及对病情严重程度的评估价值研究[J].,2022,(23):4484-4488
氧化应激指标与子宫内膜异位症的关系及对病情严重程度的评估价值研究
Study on the Relationship between Oxidative Stress Index and Endometriosis and Its Evaluation Value to the Severity of Endometriosis
投稿时间:2022-04-23  修订日期:2022-05-19
DOI:10.13241/j.cnki.pmb.2022.23.017
中文关键词: 子宫内膜异位症  氧化应激指标  病情严重程度
英文关键词: Endometriosis  Oxidative stress index  Lseverity of illness
基金项目:陕西省科技厅重点研发项目(2022SF-408)
作者单位E-mail
何海燕 空军军医大学第二附属医院妇产科 陕西 西安 710038 td_hehy@126.com 
岳 娟 空军军医大学第二附属医院妇产科 陕西 西安 710038  
周 麟 空军军医大学第二附属医院妇产科 陕西 西安 710038  
宋 琪 空军军医大学第二附属医院妇产科 陕西 西安 710038  
李 荣 空军军医大学第二附属医院妇产科 陕西 西安 710038  
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中文摘要:
      摘要 目的:分析氧化应激指标与子宫内膜异位症(以下简称内异症)的关系及对病情严重程度的评估价值。方法:选择我院自2019年5月至2022年5月接诊的126例内异症患者作为观察组,另选同期的126例卵巢良性肿瘤患者作为对照组。检测所有患者血清氧化应激指标,包括脂质过氧化特异性产物8-异前列腺素F2α(8-iso-PGF2α)、人活性氧自由基(ROS)和对氧磷酶-1(PON-1)水平,使用Pearson相关性分析氧化应激指标与美国生殖医学协会子宫内膜异位症分期(r-AFS)评分的相关性,通过多因素Logistic回归分析和AUC评价氧化应激指标对中重度囊肿粘连的预测价值。结果:观察组血清8-iso-PGF2α、ROS水平均高于对照组,PON-1水平低于对照组(P<0.05);在126例内异症患者中,中重度组血清8-iso-PGF2α、ROS水平均高于微轻度组,PON-1水平低于微轻度组(P<0.05);经Pearson相关性分析,内异症患者血清8-iso-PGF2α、ROS水平均与r-AFS评分呈正相关,PON-1水平与r-AFS评分呈负相关(P<0.05);经多因素Logistic回归分析,血清8-iso-PGF2α、ROS和PON-1均是内异症患者发生中重度囊肿粘连的独立预测因素(P<0.05);经ROC曲线分析,血清8-iso-PGF2α、ROS联合PON-1预测内异症患者发生中重度囊肿粘连的AUC为0.912。结论:内异症患者血清8-iso-PGF2α、ROS水平均明显升高,PON-1水平明显降低,三者水平与病情严重程度密切相关,联合预测中重度囊肿粘连的效能较好,值得进一步研究应用。
英文摘要:
      ABSTRACT Objective: To analyze the relationship between oxidative stress index and endometriosis (endometriosis) and evaluate the severity of the disease. Methods: A total of 126 endometriosis patients admitted to our hospital from May 2019 to May 2022 were selected as the observation group, and 126 patients with benign ovarian tumors during the same period were selected as the control group. Serum oxidative stress indicators in all patients were detected, including lipid peroxidation specific product 8-isoprostaglandin F2α (8-iso-PGF2α), human reactive oxygen species (ROS) and paraoxonase-1 (PON-1) ) level, Pearson correlation was used to analyze the correlation between oxidative stress index and American Society for Reproductive Medicine endometriosis stage (r-AFS) score, and multivariate Logistic regression analysis and AUC were used to evaluate oxidative stress index for moderate to severe Predictive value of cyst adhesions. Results: The levels of serum 8-iso-PGF2α and ROS in the observation group were higher than those in the control group, and the level of PON-1 was lower than that in the control group (P<0.05). The levels of ROS were higher than those in the mild group, and the level of PON-1 was lower than that in the mild group (P<0.05). The Pearson correlation analysis showed that the levels of serum 8-iso-PGF2α and ROS in patients with endometriosis were significantly related to r-AFS. The scores were positively correlated, and the level of PON-1 was negatively correlated with the r-AFS score(P<0.05). After multivariate Logistic regression analysis, serum 8-iso-PGF2α, ROS and PON-1 were all moderate to severe in patients with endometriosis. Independent predictors of cyst adhesion (P<0.05); ROC curve analysis showed that the AUC of serum 8-iso-PGF2α, ROS combined with PON-1 for predicting moderate to severe cyst adhesion in patients with endometriosis was 0.912. Conclusion: The serum levels of 8-ISO-PGF2 α and ROS in patients with endodynia are significantly increased, while the levels of PON-1 are significantly decreased, the levels of the three are closely related to the severity of the disease, and their combined efficacy in predicting the adhesion of moderate to severe cysts is good, which is worthy of further study and application.
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