| 王冰心,曹海育,李建英,孙 静,杨 培.医用保湿霜对湿疹患者皮肤屏障、皮损状况及炎症因子的影响[J].,2022,(22):4351-4355 |
| 医用保湿霜对湿疹患者皮肤屏障、皮损状况及炎症因子的影响 |
| Effect of Medical Moisturizing Cream on Skin Barrier, Skin Lesions and Inflammatory Factors in Patients with Eczema |
| 投稿时间：2022-04-28 修订日期：2022-05-24 |
| DOI：10.13241/j.cnki.pmb.2022.22.029 |
| 中文关键词: 医用护肤品 湿疹 皮肤屏障损伤 免疫指标 血清因子 |
| 英文关键词: Medical skin care products Eczema Skin barrier damage Immune indicators Serum factors |
| 基金项目:2020年度石家庄市科学技术研究与发展计划项目（201200543）；2018年河北省卫健委重点科技研究计划项目（20181009） |
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| 中文摘要: |
| 摘要 目的：探究医用护肤品对湿疹患者皮肤屏障损伤、免疫指标和血清因子的影响。方法：选取2020年12月~2021年3月来我院皮肤科就诊治疗的115例慢性湿疹的患者，按照其治疗不同分为单药组（n=66）与联合组（n=49），其中单药组外涂糠酸莫米松乳膏，联合组外涂糠酸莫米松乳膏加用护肤品（保湿霜）。观察并记录治疗前后两组患者血清白细胞介素（IL）-2、IL-4、IL-5、Th细胞群、IgE水平及嗜酸性粒细胞（EOS）数目变化。对比两组患者湿疹病情严重程度评分差异。分析两组患者皮肤屏障功能[经表皮水分流失（TEWL）、皮肤油脂（SC）和角质层含水量（WCSC）]差异，并对比两组患者的临床疗效。结果：治疗后，联合组总有效率显著高于单药组（P<0.05）。两组患者血清IL-2水平与治疗前相比明显升高，而IL-4、IL-5水平显著降低，且联合组较单药组变化更为明显（P<0.05）。两组患者Th1、Th2与治疗前相比均显著下降，但联合组Th1/Th2比值较单药组显著升高（P<0.05）。两组患者外周血IgE、EOS与治疗前相比明显降低，且联合组更为明显（P<0.05）。两组患者瘙痒、皮损面积评分及EASI评分与治疗前相比下降明显，且联合组优于单药组（P<0.05）。两组患者TEWL指标与治疗前相比明显降低，而WCSC和SC指标显著升高，且联合组较单药组变化更为明显（P<0.05）。治疗后，两组患者皮损处TLR4，MyD88及NF-κB mRNA表达量与治疗前相比明显降低，且联合组更为明显，差异均有统计学意义（P<0.05）。结论：糠酸莫米松乳膏联合医用护肤品能够修复湿疹患者皮肤屏障损伤，调节免疫指标和血清因子的变化，改善湿疹患者临床症状。其机制可能与抑制TLR4/MyD88/NF-κB信号通路有关。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effects of medical skin care products on skin barrier damage, immune indicators and serum factors in patients with eczema. Methods: 115 patients with chronic eczema who came to the dermatology department of our hospital from December 2020 to March 2021 were selected and divided into single drug group (n=66) and combined group (n=49) according to their treatment. Both groups were externally coated with mometasone furoate cream plus skin care products. The changes of serum interleukin (IL) -2, IL-4, IL-5, Th cell group, IgE level and eosinophil (EOS) number in the two groups were observed and recorded before and after treatment. Compare the score difference of eczema severity between the two groups. Analyze the difference of skin barrier function (TEWL, SC and WCSC) between the two groups, and compare the clinical efficacy of the two groups. Results: after treatment, the total effective rate of the combined group was significantly higher than that of the single drug group (P<0.05). The levels of serum IL-2 in the two groups were significantly higher than those before treatment, while the levels of IL-4 and IL-5 were significantly lower, and the changes in the combined group were more obvious than those in the single drug group (P<0.05). Th1 and Th2 in both groups decreased significantly compared with those before treatment, but the ratio of th1/th2 in the combined group was significantly higher than that in the single drug group (P<0.05). IgE and EOS in peripheral blood of the two groups were significantly lower than those before treatment, and the combined group was more obvious (P<0.05). The scores of pruritus, lesion area and easi in the two groups decreased significantly compared with those before treatment, and the combined group was better than the single drug group (P<0.05). Compared with the pre-treatment, the indexes of TEWL in the two groups decreased significantly, while the indexes of WCSC and SC increased significantly, and the changes in the combined group were more obvious than those in the single drug group (P<0.05). After treatment, TLR4, MyD88 and NF-κB The expression of B mRNA was significantly decreased compared with that before treatment, especially in the combined group (P<0.05). Conclusion: Mometasone furoate cream combined with medical skin care products can repair the damage of skin barrier in patients with eczema, regulate the changes of immune indicators and serum factors, and improve the clinical symptoms of patients with eczema. The mechanism may be related to the inhibition of TLR4 / MyD88 / NF-κB signal pathway. |
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