| 斯依提·阿木提,沙丽帕·艾尼瓦尔,阿地力江·伊明,王冰华,薛志琴,刘文娟.缓激肽受体B1R对SD大鼠阴茎勃起功能影响的实验研究[J].,2022,(22):4219-4223 |
| 缓激肽受体B1R对SD大鼠阴茎勃起功能影响的实验研究 |
| Experimental Study on the Effect of Bradykinin Receptor B1R on the Erectile Function of the SD Rat |
| 投稿时间：2022-04-25 修订日期：2022-05-21 |
| DOI：10.13241/j.cnki.pmb.2022.22.004 |
| 中文关键词: 激肽-激肽释放酶系统 缓激肽受体B1 勃起功能障碍 炎症 |
| 英文关键词: Kinin-kallikrein system Bradykinin receptor B1 Erectile dysfunction Inflammation |
| 基金项目:新疆维吾尔自治区科学技术厅青年基金项目（2019D01C198） |
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| 中文摘要: |
| 摘要 目的：研究缓激肽受体B1R对大鼠阴茎勃起功能的影响。方法：通过腹腔注射B1受体激动剂[Des-Arg9]-Bradykinin与B1受体抑制剂Lys-(des-Arg9, Leu8)-Bradykinin，观察各组大鼠阴茎勃起功能，通过HE染色和Masson染色观察大鼠阴茎组织形态变化及纤维化水平的变化，通过Western-blot 检测大鼠阴茎组织TGF-β1、TNF-α与IL-6等炎症因子的表达情况。结果：（1）B1受体激动剂显著抑制大鼠阴茎勃起功能，并升高阴茎胶原纤维/肌原纤维比值；而B1受体抑制剂显著提升大鼠阴茎勃起功能，并降低阴茎胶原纤维/肌原纤维比值；（2）B1受体激动剂显著升高大鼠阴茎TGF-β1、TNF-α与IL-6蛋白表达水平，而B1受体抑制剂降低大鼠阴茎TGF-β1、TNF-α与IL-6蛋白表达水平。结论：B1受体可能通过炎症因子、阴茎组织纤维化影响阴茎勃起功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of bradykinin receptor B1R on the erectile function of the rat penis. Methods: By intraperitoneal injection of B1 receptor agonist [Des-Arg9]-Bradykinin and B1 receptor inhibitor Lys-(des-Arg9, Leu8)-Bradykinin, The penile erectile function of rats in each group, the morphological changes and fibrosis level of rat penile tissues were observed, and the expression of TGF-β1, TNF -α and IL-6 were detected. Results: (1) B1 agonists significantly inhibited the erectile function and increased the penile collagen fiber/myogenic fiber ratio, while B1 receptor inhibitors significantly enhanced the erectile function and decreased the penile collagen fiber/myogenic fiber ratio; (2) B1 agonists significantly increased the expression levels of TGF-β1, TNF-α and IL-6 in the rat penis, while B1 receptor inhibitors decreased TGF-β1, TNF-α and IL-6 protein expression levels in the rat penis. Conclusion: B1 receptor can affect penile tissue fibrosis and ultimately penile erectile function through inflammatory factors and other pathways. |
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