| 徐芳琴,郭 超,赵 敏,鲁 毓,胡子龙,田向荣.鹰嘴豆种子的化学成分研究[J].,2022,(22):4215-4218 |
| 鹰嘴豆种子的化学成分研究 |
| Study on Chemical Constituents from The Seeds of Cicer arietinum Linn. |
| 投稿时间：2022-05-22 修订日期：2022-06-18 |
| DOI：10.13241/j.cnki.pmb.2022.22.003 |
| 中文关键词: 鹰嘴豆 分离 化学成分 结构鉴定 |
| 英文关键词: Cicer arietinum Isolation Chemical constituents Structure elucidation |
| 基金项目:咸阳市秦创源科技创新专项（2021ZDZX-NY-0001） |
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| 中文摘要: |
| 摘要 目的：探究维药鹰嘴豆种子的化学成分，从药效物质基础的角度为阐明鹰嘴豆的营养功能与药用价值奠定基础。方法：将鹰嘴豆75%乙醇提取物分散于水中，分别通过石油醚、乙酸乙酯和正丁醇萃取获得不同的萃取段。对正丁醇萃取段通过正相硅胶、凝胶柱层析，以及半制备高效液相色谱进行分离纯化，通过核磁共振氢谱和碳谱对分离纯化的单体化合物进行结构鉴定。结果：从鹰嘴豆种子中分离鉴定了8个化合物，分别为：(+)松醇(1)、乙基α-D-半乳糖苷(2)、L-色氨酸(3)、β-谷甾醇(4)、β-胡萝卜苷(5)、亚油酸甲酯(6)、亚油酸(7)和槲皮素-3-O-β-D-吡喃葡萄糖苷(8)。结论：亚油酸甲酯(6)和槲皮素-3-O-βD-吡喃葡萄糖苷(8)为首次从鹰嘴豆中分离鉴定。对鹰嘴豆中之前报道的乙基α-L-半乳糖苷的化学结构确证为乙基α-D-半乳糖苷(2)。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the chemical constituents for the seeds of Cicer arietinum Linn., and lay the foundation for clarifying the nutritional function and medicinal value of the title plants from the perspective of pharmacodynamic material basis. Methods: The 75% ethanol extract of C. arietinum was dispersed in water, and extracted extensively by petroleum ether, ethyl acetate, and n-butanol, respectively, to obtain different extraction. The n-butanol extract was isolated and purified by normal phase silica gel, Sephadex LH-20, and semi-preparative high performance liquid chromatography. The structures of the purified compounds were elucidated by 1H and 13C-NMR spectroscopy. Results: Eight compounds were identified from the seeds of C. arietinum. Their structures were identified as (+)pinitol (1), ethyl-α-D-galactopyranoside (2), L-tryptophan (3), β-sitosterol (4), β-daucosterol (5), methyl linoleate (6), linoleic acid (7), and quercetin 3-O-β-D-glucopyranoside (8). Conclusion: Methyl linoleate (6) and quercetin 3-O-β-D- glucopyranoside (8) were identified firstly from the seeds of C. arietinum. The structure of previous reported ethyl α-L-galactopyranoside in the seeds of C. arietinum was confirmed as ethyl α-D-galactopyranoside (2). |
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