| 李金燕,郭逸男,陈小凤,杜珏萌,邓高丕.红花逍遥片联合地屈孕酮治疗月经不调的临床疗效及对激素水平和血液流变学的影响[J].,2022,(21):4135-4138 |
| 红花逍遥片联合地屈孕酮治疗月经不调的临床疗效及对激素水平和血液流变学的影响 |
| Clinical Efficacy of Honghua Xiaoyao Tablets Combined with Dydrogesterone in the Treatment of Menstrual Irregularities and its Effect on Hormone Level and Hemorheology |
| 投稿时间：2022-05-23 修订日期：2022-06-19 |
| DOI：10.13241/j.cnki.pmb.2022.21.024 |
| 中文关键词: 红花逍遥片 地屈孕酮 月经不调 疗效 激素 血液流变学 |
| 英文关键词: Honghua Xiaoyao tablet Dydrogesterone Menstrual Irregularities Curative effect Hormone level Hemorheology |
| 基金项目:广东省自然科学基金项目（2018A030313469） |
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| 中文摘要: |
| 摘要 目的：观察红花逍遥片联合地屈孕酮治疗月经不调的临床效果，并分析其对患者激素水平和血液流变学的影响。方法：选取2019年4月~2021年2月在广州中医药大学第一附属医院接受诊治的68例月经不调患者，根据随机数字表法分为对照组（n=34）和观察组（n=34）。对照组患者接受地屈孕酮片治疗，观察组患者接受红花逍遥片联合地屈孕酮片治疗。观察两组临床总有效率、激素水平、血液流变学、相关量表评分和不良反应发生情况。结果：与对照组的61.76%（21/34）相比，观察组的临床总有效率88.24%（30/34）进一步升高（P<0.05）。与对照组治疗2个周期后相比，观察组月经失血图（PBAC）评分更低，中华生存质量量表（ChQOL）评分更高，促卵泡成熟激素（FSH）、黄体生成激素（LH）、全血高、低切黏度（HBV 和 LBV）、纤维蛋白原（FIB）水平更低，孕酮（P）、雌二醇（E2）水平更高（P<0.05）。两组不良反应发生率组间对比无差异（P>0.05）。结论：红花逍遥片联合地屈孕酮可有效改善月经不调患者的临床症状，促进患者生存质量提高，可能与改善激素水平和血液流变学有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the clinical efficacy of Honghua Xiaoyao tablets combined with Dydrogesterone in the treatment of menstrual irregularities, and to analyze its effect on hormone level and hemorheology. Methods: 68 patients with Menstrual Irregularities who were treated in The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from April 2019 to February 2021 were selected, and they were randomly divided into control group (n=34) and observation group (n=34) according to random number table method. Patients in the control group were treated with Dydrogesterone tablets, while patients in the observation group were treated with Honghua Xiaoyao tablets combined with Dydrogesterone tablets. The clinical total effective rate, hormone level, hemorheology, related scale score and adverse reactions of the two groups were observed. Results: Compared with 61.76% (21/34) of the control group, the clinical total effective rate of the observation group was 88.24% (30/34) further increased (P<0.05). Compared with the control group at 2 cycles after treatment, the observation group had lower scores on Pictorialblood loss assessment chart (PBAC), higher scores on Chinese quality of life scale (ChQOL), lower levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), whole blood high and low shear viscosity (HBV and LBV), fibrinogen (FIB), and higher levels of progesterone (P) and estradiol (E2) (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Honghua Xiaoyao tablets combined with Dydrogesterone can effectively improve the clinical symptoms of patients with Menstrual Irregularities, and improve the quality of life of patients, which may be related to the improvement of hormone levels and hemorheology. |
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