| 赵智凝,徐永妮,李 烁,何 莹,刘 芳.血清miR-21表达水平与子宫脱垂和阴道壁脱垂的相关性[J].,2022,(21):4107-4111 |
| 血清miR-21表达水平与子宫脱垂和阴道壁脱垂的相关性 |
| Correlation of Serum MiR-21 Expression with Uterine Prolapse and Vaginal Wall Prolapse |
| 投稿时间：2022-05-05 修订日期：2022-05-30 |
| DOI：10.13241/j.cnki.pmb.2022.21.019 |
| 中文关键词: 子宫脱垂 阴道壁脱垂 胶原蛋白 血清miR-21 相关性 |
| 英文关键词: Uterine prolapse Vaginal wall prolapse Collagen protein Serum miR-21 Relevance |
| 基金项目:国家自然科学基金项目（81872077）；陕西省自然科学基金项目（2022SF-378） |
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| 中文摘要: |
| 摘要 目的：探讨血清miR-21表达水平与子宫脱垂和阴道壁脱垂的相关性。方法：选取我院2017年12月到2020年12月共收治的60例子宫脱垂和阴道壁脱垂的患者作为观察组，另取60例来我院体检的健康女性作为对照组，分析两组患者胶原蛋白Ⅰ、Ⅲ和miR-21表达水平，并分析血清miR-21表达水平与子宫脱垂和阴道壁脱垂的相关性。对所有患者经盆底重建术和相关治疗之后，将术后1年子宫和阴道壁基本复位未见脱垂，且POP-Q分度＜Ⅱ度的40例患者分为预后良好组，将术后1年内再次发生子宫脱垂和阴道壁脱垂，且POP-Q分度≥Ⅱ度的20例患者分为预后不良组，对比两组患者的临床情况，并分期血清miR-21表达水平对于子宫脱垂和阴道壁脱垂的预后预测价值。结果：两组患者胶原蛋白Ⅰ、Ⅲ和血清miR-21表达水平对比差异显著，观察组患者胶原蛋白Ⅰ、Ⅲ水平低于对照组，观察组患者血清miR-21水平高于对照组（P＜0.05）；Spearman相关分析结果显示：胶原蛋白Ⅰ、Ⅲ水平与子宫脱垂和阴道壁脱垂呈负相关，血清miR-21与子宫脱垂和阴道壁脱垂呈正相关（P＜0.05）；预后良好组与预后不良组患者孕次、脱垂部位、胶原蛋白Ⅰ、Ⅲ情况对比无差异（P＞0.05），预后良好组与预后不良组患者年龄、BIM、产次、miR-21情况对比有差异（P＜0.05）；logistic回归分析结果得出，只有血清miR-21水平和BMI是子宫脱垂和阴道壁脱垂的预后独立因素（P＜0.05）。结论：胶原蛋白Ⅰ、Ⅲ和血清miR-21表达水平与子宫脱垂和阴道壁脱垂疾病具有明显相关性，因此可以考虑应用三种指标对患者进行诊断和治疗参考。而仅有血清miR-21水平和BIM水平是子宫脱垂和阴道壁脱垂的预后独立因素，可以用两者的水平来判断患者的预后情况，及时采取措施提升治疗方法。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum miR-21 expression and uterine prolapse and vaginal wall prolapse. Methods: A total of 60 patients with uterine prolapse and vaginal wall prolapse who were treated in our hospital from December 2017 to December 2020 were selected as the observation group, and another 60 healthy women who came to our hospital for physical examination were selected as the matched group, The correlation of serum miR-21 expression with uterine prolapse and vaginal wall prolapse was analyzed. After pelvic floor reconstruction and related treatment, 40 patients who had no prolapse in Zigong and vaginal wall and whose POP-Q score was less than or equal to grade II one year after operation were divided into good prognosis group, and 20 patients who had uterine prolapse and vaginal wall prolapse again within one year after operation and whose POP-Q score was greater than or equal to grade II were divided into poor prognosis group. The prognostic value of serum miR-21 expression level for uterine prolapse and vaginal wall prolapse was also evaluated. Results: There were differences in the expression levels of collagen I, III and serum miR-21 between the two groups. The levels of collagen I and III in the observation group were lower than those in the matched group, and the level of serum miR-21 in the observation group was higher than that in the matched group (P<0.05); Spearman correlation analysis showed that the levels of collagen I and collagen III were negatively correlated with uterine prolapse and vaginal wall prolapse (P<0.05), and serum miR-21 was positively correlated with uterine prolapse and vaginal wall prolapse (P<0.05); There was no difference in pregnancy times, prolapse site, collagen Ⅰ and collagen Ⅲ between the two groups (P<0.05). There were differences in age, BIM, parity and miR-21 between the two groups (P<0.05); Logistic regression analysis showed that only serum miR-21 level and BMI were independent prognostic factors for uterine prolapse and vaginal wall prolapse (P<0.05). Conclusion: Collagen I, III and serum miR-21 expression levels are significantly correlated with uterine prolapse and vaginal wall prolapse, so three indicators can be considered for diagnosis and treatment of patients. However, only serum miR-21 level and BIM level are independent prognostic factors for uterine prolapse and vaginal wall prolapse, and the two levels can be used to judge the prognosis of patients and take timely measures to improve treatment methods. |
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