| 郭平平,管丽红,梅丽丽,王雯婷,祝小欢,李小平.健康体检人群幽门螺杆菌感染的影响因素分析及对糖脂代谢和血清PGⅠ、PGⅡ和G-17的影响[J].,2022,(21):4102-4106 |
| 健康体检人群幽门螺杆菌感染的影响因素分析及对糖脂代谢和血清PGⅠ、PGⅡ和G-17的影响 |
| Analysis of Influencing Factors of Helicobacter Pylori Infection in Healthy People and its Effects on Glucose and Lipid Metabolism and Serum PG Ⅰ, PG Ⅱ and G-17 |
| 投稿时间：2022-05-10 修订日期：2022-05-31 |
| DOI：10.13241/j.cnki.pmb.2022.21.018 |
| 中文关键词: 健康体检人群 幽门螺杆菌 影响因素 糖脂代谢 胃蛋白酶原 胃泌素17 |
| 英文关键词: Health examination population Helicobacter pylori Influencing factors Glucose and lipid metabolism Pepsinogen Gastrin 17 |
| 基金项目:2022年度江西省卫生健康委科技计划项目（SKJP_220219716） |
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| 中文摘要: |
| 摘要 目的：分析健康体检人群幽门螺杆菌（Hp）感染的影响因素，并探讨Hp感染对糖脂代谢和血清胃蛋白酶原Ⅰ（PGⅠ）、胃蛋白酶原Ⅱ（PGⅡ）和胃泌素17（G-17）的影响。方法：选择2017年1月~2019年12月期间在我院进行Hp检查的117例健康体检者进行问卷调查，分析其Hp感染情况，并应用多因素Logistic回归分析健康体检人群Hp感染的影响因素。将体检者分为Hp阳性组和Hp阴性组，对比两组血糖、血脂指标以及血清PGⅠ、PGⅡ、G-17水平。结果：117例受试体检者中Hp阳性49例，阳性率为41.88%，其中男性感染率为50.85%（30/59），显著高于女性感染率的32.76%（19/58）（x2=10.537，P=0.001）。不同年龄体检者Hp阳性率比较差异无统计学意义（P>0.05）。不同学历体检者Hp阳性率比较差异无统计学意义（P>0.05）。多因素Logistic回归分析结果显示，饮酒、经常喝生水、经常在外就餐、经常吃辛辣食物、有家人Hp感染史是健康体检人群Hp感染的危险因素（P＜0.05）。Hp阳性组的空腹血糖（FPG）、甘油三脂（TG）、总胆固醇（TC）、低密度脂蛋白（LDL-C）水平均高于Hp阴性组，而高密度脂蛋白（HDL-C）水平则低于Hp阴性组（P＜0.05）。Hp阳性组的血清PGⅠ、PGⅡ、G-17水平均高于Hp阴性组（P＜0.05）。结论：饮酒、经常喝生水、经常在外就餐、经常吃辛辣食物、有家人Hp感染史是健康体检人群Hp感染的危险因素，糖脂代谢及血清PGⅠ、PGⅡ、G-17水平变化与Hp感染有关。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the influencing factors of Helicobacter pylori infection (Hp) in healthy people and its effects on glucose and lipid metabolism and serum pepsinogenⅠ(PGⅠ), pepsinogenⅡ(PGⅡ) and gastrin-17 (G-17). Methods: 120 physical examination personnel who underwent Hp examination in our hospital from January 2017 to December 2019 were selected for questionnaire survey, the Hp infection of physical examination personnel was analyzed, and the influencing factors of Hp infection in physical examination population were analyzed by multivariate logistic regression. The patients were divided into Hp positive group and Hp negative group. The blood glucose indexes, blood lipid indexes and the levels of serum PG Ⅰ, PG Ⅱ and G-17 indexes were compared between the two groups. Results: There were 49 Hp patients in 117 physical examination personnel, and the infection rate was 41.88%, of which the male infection rate was 50.85%, which was significantly higher than the female infection rate of 32.76% (x2=10.537, P=0.001). Multivariate logistic regression analysis showed that drinking alcohol, often drinking raw water, often eating out, often eating spicy food and family history of Hp infection were the risk factors of Hp infection in the physical examination population (P<0.05). The levels of fasting blood glucose (FPG), triglyceride (TG), total cholesterol (TC) and low density lipoprotein (LDL-C) in Hp positive group were higher than those in Hp positive group, while the level of high density lipoprotein (HDL-C) was lower than that in Hp negative group (P<0.05). The levels of PG Ⅰ, PG Ⅱ and G-17 in Hp positive group were higher than those in Hp negative group (P<0.05). Conclusion: Drinking alcohol, often drinking raw water, often eating out, often eating spicy food and family history of Hp infection are the risk factors of Hp infection in physical examination population. The changes of glucose and lipid metabolism and serum PG Ⅰ, PG Ⅱ, G-17 levels are related to Hp infection. |
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