| 张芮仙,张善东,齐 涵,乔卫红,赵劲红.老年人睡眠障碍的影响因素及对机体免疫状态、认知功能和生活质量的影响[J].,2022,(21):4071-4075 |
| 老年人睡眠障碍的影响因素及对机体免疫状态、认知功能和生活质量的影响 |
| Influencing Factors of Sleep Disorders in the Elderly and Their Effects on Immune Status, Cognitive Function and Quality of Life |
| 投稿时间：2022-05-10 修订日期：2022-05-31 |
| DOI：10.13241/j.cnki.pmb.2022.21.012 |
| 中文关键词: 老年人 睡眠障碍 影响因素 免疫状态 认知功能 生活质量 |
| 英文关键词: Elderly Sleep disorders Influencing factors Immune status Cognitive function Quality of life |
| 基金项目:北京市自然科学基金项目（72020312） |
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| 中文摘要: |
| 摘要 目的：探讨老年人睡眠障碍的影响因素及对机体免疫状态、认知功能和生活质量的影响。方法：于2019年1月～2021年12月募集北京市东城区崇文门外街道社区的386例老年人为研究调查对象，统计其睡眠障碍发生率，并根据调查结果将其分为睡眠正常组和睡眠障碍组。对比两组老年人的基线资料，采用多因素Logistic回归分析该社区老年人睡眠障碍的影响因素。检测并对比两组老年人的免疫状态指标，分别采用简易智力状态检查量表（MMSE）、SF-36生活质量调查表评估所有受试者的认知功能、生活质量，并比较其在两组老年人之间的差异。结果：北京市东城区崇文门外街道社区386例老年人中，165例存在睡眠障碍，睡眠障碍发生率为42.75%。多因素Logistic回归分析结果显示，女性、无配偶或丧偶、患有慢性病、有不良生活习惯以及有不良心理状态是北京市东城区崇文门外街道社区老年人睡眠障碍发生的危险因素（OR=1.610、1.293、1.241、1.412、1.309，P均＜0.05）。睡眠障碍组CD3+、CD4+细胞阳性率、CD4+/CD8+比值均低于睡眠正常组，而CD8+细胞阳性率则高于睡眠正常组（P<0.05）。睡眠障碍组MMSE评分明显低于睡眠正常组（P<0.05）。睡眠障碍组的SF-36生活质量各维度评分均低于睡眠正常组（P<0.05）。结论：北京市东城区崇文门外街道社区老年人睡眠障碍发生率较高，其发生受到性别、婚姻状况、慢性病、生活习惯及心理状态的影响，睡眠障碍还会引起免疫状态异常以及认知功能和生活质量下降，应给予高度关注。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the influencing factors of sleep disorder and their effects on cognitive function, immune status and quality of life of the elderly in Chongwenmenwai Street community, Dongcheng District, Beijing. Methods: From January 2019 to December 2021, 386 elderly people in Chongwenmenwai Street community, Dongcheng District, Beijing were recruited as the research subjects. The incidence of sleep disorders was counted, and they were divided into normal sleep group and sleep disorder group according to the survey results. The baseline data of the two groups were compared, and the influencing factors of sleep disorders of the elderly in the community were analyzed by multivariate logistic regression. The immune status indexes of the elderly in the two groups were detected and compared. The simple mental state examination scale (MMSE) and SF-36 quality of life questionnaire were used to evaluate the cognitive function and quality of life of all subjects, and the differences between the two groups were compared. Results: Of the 386 elderly in Chongwenmenwai Street community, Dongcheng District, Beijing, 165 had sleep disorders, the incidence of sleep disorders was 42.75%. The results of multivariate logistic regression analysis showed that women, without spouse or widowed, suffering from chronic diseases, bad living habits and bad mental state were the risk factors of sleep disorders in the elderly in Chongwenmenwai Street community, Dongcheng District, Beijing (OR=1.610, 1.293, 1.241, 1.412, 1.309; P all＜0.05). The positive rates of CD3+, CD4+ cells and CD4+/CD8+ ratio in sleep disorder group were lower than those in normal sleep group, while the positive rate of CD8+ cells was higher than that in normal sleep group (P<0.05). The MMSE score of sleep disorder group was significantly lower than that of normal sleep group(P<0.05). The scores of SF-36 quality of life in each dimension in sleep disorder group were lower than those in normal sleep group (P<0.05). Conclusion: The incidence of sleep disorders among the elderly in Chongwenmenwai Street community, Dongcheng District, Beijing is high, which is affected by gender, marital status, chronic diseases, living habits and psychological status, sleep disorders can also cause abnormal immune status and decline in cognitive function and quality of life, which should be paid high attention. |
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