文章摘要
孙陈静,刘 燕,成淑英,秦佃红,贾红玲,隋淑香,陈 涛.羚羊角胶囊联合拉莫三嗪治疗小儿癫痫的临床研究[J].,2022,(20):3997-4000
羚羊角胶囊联合拉莫三嗪治疗小儿癫痫的临床研究
Clinical Study of LingYangJiao Capsule Combined with Lamotrigine in the Treatment of Children with Epilepsy
投稿时间:2022-04-06  修订日期:2022-04-30
DOI:10.13241/j.cnki.pmb.2022.20.039
中文关键词: 羚羊角胶囊  拉莫三嗪  小儿癫痫  疗效  安全性
英文关键词: LingYangJiao capsule  Lamotrigine  Children with epilepsy  Efficacy  Safety
基金项目:山东省中医药科技发展计划项目(2013ZDZK-075)
作者单位E-mail
孙陈静 东营市人民医院药学部 山东 东营 257000 sunchenjing01@163.com 
刘 燕 东营市人民医院药学部 山东 东营 257000  
成淑英 东营市人民医院药学部 山东 东营 257000  
秦佃红 东营市人民医院药学部 山东 东营 257000  
贾红玲 东营市人民医院药学部 山东 东营 257000  
隋淑香 东营市人民医院儿科 山东 东营 257000  
陈 涛 山东中医药大学附属医院儿科 山东 济南 250000  
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中文摘要:
      摘要 目的:观察羚羊角胶囊联合拉莫三嗪治疗小儿癫痫的治疗效果。方法:选取2018年1月~2021年1月期间来东营市人民医院就诊的小儿癫痫患儿100例,按照信封抽签法分为对照组(拉莫三嗪治疗)和研究组(羚羊角胶囊联合拉莫三嗪治疗),各为50例,连续治疗12周。对比两组疗效,癫痫症状、自控能力、认知功能改善情况以及炎症因子和神经损伤指标变化,记录治疗不良反应。结果:与对照组76.00%的临床总有效率相比,研究组的94.00%明显更高(P<0.05)。研究组治疗后癫痫发作次数少于对照组,平均症状持续时间短于对照组(P<0.05)。研究组治疗后操作智商(PIQ)、言语智商(VIQ)和全智商(FIQ)评分高于对照组(P<0.05)。研究组治疗后血清神经元特异性烯醇化酶(NSE)、信号素3A(SEM3A)、白介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。两组患儿不良反应发生率组间对比无统计学差异(P>0.05)。结论:羚羊角胶囊联合拉莫三嗪治疗小儿癫痫,可提高患儿认知功能和自控能力,调节NSE、IL-2、S-100β、TNF-α水平,促进症状改善。
英文摘要:
      ABSTRACT Objective: To observe the therapeutic effect of LingYangJiao capsule combined with lamotrigine in the treatment of children with epilepsy. Methods: 100 children with epilepsy who came to our hospital from January 2018 to January 2021 were selected. The children were divided into control group (lamotrigine treatment) and study group (LingYangJiao capsule combined with lamotrigine treatment) according to envelope lottery method, with 50 cases in each group, the treatment lasted for 12 weeks. The efficacy, the improvement of epileptic symptoms, self-control ability, cognitive function, inflammatory factors and nerve injury indexes changes were compared between the two groups, and the adverse reactions were recorded. Results: Compared with 76.00% of total clinical effective rate of the control group, 94.00% of the study group was significantly higher (P<0.05). The number of seizures of the study group was less than that of the control group, and the average symptom duration was shorter than that of the control group (P<0.05). The performance intelligence quotient (PIQ), verbal intelligence quotient (VIQ) and full intelligence quotient (FIQ) scores of the study group were higher than those of the control group (P<0.05). After treatment, the levels of neuron-specific enolase (NSE), Semaphore 3A (sem3a), interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α) of the study group were lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Lingyangjiao capsule combined with lamotrigine in the treatment of children with epilepsy can improve children's cognitive function and self-control ability, and regulate NSE, IL-2 and S-100 β, TNF- α levels, and promote symptom improvement.
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