| 高 艳,王 会,杨 林,曾 欣,汤雪瑶.超微血流显像联合剪切波弹性成像在最大径≤2 cm乳腺癌诊断与病理评估中的应用价值[J].,2022,(20):3991-3996 |
| 超微血流显像联合剪切波弹性成像在最大径≤2 cm乳腺癌诊断与病理评估中的应用价值 |
| Application Value of Superb Microvascular Imaging Combined with Shear Wave Elastography in the Diagnosis and Pathological Evaluation of Breast Cancer with Maximum Diameter ≤ 2 cm |
| 投稿时间：2022-04-06 修订日期：2022-04-28 |
| DOI：10.13241/j.cnki.pmb.2022.20.038 |
| 中文关键词: 乳腺癌 最大径≤2 cm 超微血流显像 剪切波弹性成像 诊断 临床病理特征 |
| 英文关键词: Breast cancer Maximum diameter ≤2 cm Superb microvascular imaging Shear wave elastography Diagnosis Clinicopathological features |
| 基金项目:四川省卫生健康委课题基金资助项目（18PJ461） |
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| 中文摘要: |
| 摘要 目的：探讨超微血流显像（SMI）联合剪切波弹性成像（SWE）在最大径≤2 cm乳腺癌诊断与病理评估中的应用价值。方法：选取成都市第三人民医院2018年6月至2021年6月收治的最大径≤2 cm疑似乳腺癌患者125例，以手术病理结果为金标准，分为良性组49例与恶性组76例，比较两组SMI Alder分级、SWE检查参数[最大弹性值（Emax）、平均弹性值（Emean）、最小弹性值（Emin）]，分析SMI Alder分级与SWE检查参数的相关性及对乳腺癌的诊断价值，并对比不同临床病理特征乳腺癌患者的Alder分级、Emax、Emean、Emin。结果：恶性组与良性组SMI Alder分级比较差异有统计学意义（P＜0.05）；恶性组Emax、Emean、Emin高于良性组（P＜0.05）；恶性组SMI Alder分级与SWE检查参数Emax、Emean、Emin呈正相关（P＜0.05）；SMI Alder分级、Emax、Emean、Emin联合诊断最大径≤2 cm乳腺癌的AUC为0.917（95%CI：0.870～0.963），优于各指标单独诊断；恶性组不同肿瘤直径、组织学分级、有无腋窝淋巴结转移患者SMI Alder分级、Emax、Emean、Emin比较差异有统计学意义（P＜0.05）。结论：SMI联合SWE检查在最大径≤2 cm乳腺癌中具有较为可靠的诊断价值，且各参数与肿瘤直径、组织学分级、腋窝淋巴结转移密切相关，可为临床评估病理进展提供有效信息。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the application value of superb microvascular imaging (SMI) combined with shear wave elastography (SWE) in the diagnosis and pathological evaluation of breast cancer with maximum diameter ≤2 cm. Methods: 125 suspected breast cancer patients with maximum diameter ≤ 2 cm who were admitted to Chengdu Third People's Hospital from June 2018 to June 2021 were selected, and they were divided into benign group with 49 cases and malignant group with 76 cases according to the gold standard of surgical and pathological results. The SMI Alder classification and SWE examination parameters [maximum elasticity (Emax), average elasticity (Emean) and minimum elasticity (Emin)] of the two groups were compared. The correlation between SMI Alder grade and SWE parameters and its diagnostic value for breast cancer were analyzed, and the Alder grade, Emax, Emean, Emin in patients with different pathological features of breast cancer were compared. Results: There was significant difference in SMI Alder grade between malignant group and benign group (P＜0.05). Emax, Emean and Emin in malignant group were higher than those in benign group (P＜0.05). In malignant group, SMI Alder grade was positively correlated with SWE parameters Emax, Emean and Emin (P＜0.05). The AUC of SMI Alder grade, Emax, Emean and Emin combined diagnosis of breast cancer with maximum diameter ≤2 cm was 0.917 (95%CI: 0.870-0.963), which was better than that of each index alone. There were statistically significant differences in tumor diameter, histological grade, SMI Alder grade, Emax, Emean, Emin and patients with axillary lymph node metastasis in malignant group (P＜0.05). Conclusion: SMI combined with SWE has relatively reliable diagnostic value in breast cancer with maximum diameter ≤2 cm, and each parameter is closely related to tumor diameter, histological grade and axillary lymph node metastasis, which can provide effective information for clinical evaluation of pathological progress. |
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