| 韩 莹,胥青芝,刘云祥,陈娜娜,樊 澍.健康体检人群幽门螺杆菌感染的影响因素分析及其与胃蛋白酶原和颈动脉粥样硬化的关系研究[J].,2022,(20):3852-3858 |
| 健康体检人群幽门螺杆菌感染的影响因素分析及其与胃蛋白酶原和颈动脉粥样硬化的关系研究 |
| Analysis of Influencing Factors of Helicobacter Pylori Infection in Health Physical Examination Population and its Relationship Study with Pepsinogen and Carotid Atherosclerosis |
| 投稿时间：2022-04-06 修订日期：2022-04-30 |
| DOI：10.13241/j.cnki.pmb.2022.20.010 |
| 中文关键词: 健康体检 幽门螺杆菌感染 影响因素 胃蛋白酶原 炎症 颈动脉粥样硬化 |
| 英文关键词: Health physical examination Helicobacter pylori infection Influencing factors Pepsinogen Inflammation Carotid atherosclerosis |
| 基金项目:北京市自然科学基金面上项目（7172079） |
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| 中文摘要: |
| 摘要 目的：分析健康体检人群幽门螺杆菌（Hp）感染的影响因素，并进一步探讨健康体检人群Hp感染与胃蛋白酶原（PG）和颈动脉粥样硬化（CAS）的关系。方法：选取2021年3月～2022年3月在我院体检的146例接受Hp筛查的健康体检者，根据碳13尿素呼气试验结果分为Hp阳性组（n=62）和Hp阴性组（n=84）。采用单因素和多因素Logistic回归分析健康体检人群Hp感染的影响因素，比较两组血清PGⅠ、PGⅡ、PGⅠ/PGⅡ水平和CAS比例。Spearman相关系数分析Hp阳性组DOB值与血清PGⅠ、PGⅡ、PGⅠ/PGⅡ和颈动脉内中膜厚度（CIMT）的相关性。结果：单因素分析显示，与Hp阴性组比较，Hp阳性组年龄更大，家族Hp感染史、吸烟、饮酒、饮食口味辛辣、经常摄入腌制食品、共用餐具比例更高，经常喝茶、经常摄入水果/蔬菜比例更低（均P＜0.05）。多因素Logistic回归分析显示，年龄增加、家族Hp感染史、吸烟、饮食口味辛辣、经常摄入腌制食品、共用餐具为健康体检人群Hp感染的独立危险因素，经常喝茶、经常摄入水果/蔬菜为独立保护因素（均P＜0.05）。Hp阳性组血清PGⅠ、PGⅡ水平和CAS比例高于Hp阴性组，PGⅠ/PGⅡ低于Hp阴性组（均P＜0.05）。Spearman相关系数显示，Hp阳性组DOB值与血清PGⅠ、PGⅡ和CIMT呈正相关，与PGⅠ/PGⅡ呈负相关。结论：年龄增加、家族Hp感染史、吸烟、饮食口味辛辣、经常摄入腌制食品、共用餐具是健康体检人群Hp感染的危险因素，而经常喝茶、经常摄入水果/蔬菜为健康体检人群Hp感染的保护因素，Hp感染与血清PG水平变化和CAS密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the influencing factors of Helicobacter pylori (Hp) infection in health physical examination population, and to further explore the relationship between Hp infection and pepsinogen (PG) and carotid atherosclerosis (CAS) in health physical examination population. Methods: 146 healthy physical examination persons who underwent Hp screening in our hospital from March 2021 to March 2022 were selected, and they were divided into HP-positive group (n=62) and HP-negative group (n=84) according to the results of carbon 13 urea breath test. Univariate and multivariate Logistic regression were used to analyze the influencing factors of HP infection in healthy physical examination population. The serum PG Ⅰ, PG Ⅱ, PGⅠ/PGⅡ levels and the CAS proportion were compared between the two groups. Spearman correlation coefficient was used to analyze the correlation between DOB value of HP-positive group and serum PG Ⅰ, PG Ⅱ, PGⅠ/PGⅡ and carotid intima-media thickness (CIMT). Results: Univariate analysis showed that, compared with the HP-negative group, the HP-positive group was older, had higher proportion family history of Hp infection, smoking, drinking, food tastes spicy, frequent intake salted food, shared tableware, had lower proportion frequent drank teas and frequent intake of fruits/vegetables (all P＜0.05). Multivariate Logistic regression analysis showed that increasing age, family history of Hp infection, smoking, food tastes spicy, frequent intake salted food and shared tableware were independent risk factors for Hp infection in health physical examination population, and frequent drank teas and frequent intake of fruits/vegetables were independent protective factors (all P＜0.05). Serum PGⅠ and PGⅡ levels and CAS proportion in Hp-positive group were higher than those in Hp-negative group, while PGⅠ/PGⅡ was lower than that in Hp-negative group (all P＜0.05). Spearman correlation coefficient showed that DOB value in Hp-positive group was positively correlated with PGⅠ, PGⅡ and CIMT, but negatively correlated with PGⅠ/PGⅡ. Conclusion: Increasing age, family history of HP infection, smoking, food tastes spicy, frequent intake salted food and shared tableware are the risk factors for HP infection in healthy physical examination population, while frequent drank teas and frequent intake of fruits/vegetables are the protective factors for HP infection in healthy physical examination population. HP infection is closely related to changes in serum PG level and CAS. |
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