| 胡丽花,袁 明,赵嫦娥,王亚莉,宋成文.上皮性卵巢癌患者血清CA125、IGF1、Annexin A3、HE4与卡铂耐药和预后的关系研究[J].,2022,(18):3494-3498 |
| 上皮性卵巢癌患者血清CA125、IGF1、Annexin A3、HE4与卡铂耐药和预后的关系研究 |
| Relationship Study between Serum CA125, IGF1, Annexin A3, HE4 and Carboplatin Resistance and Prognosis in Patients with Epithelial Ovarian Cancer |
| 投稿时间：2022-03-06 修订日期：2022-03-29 |
| DOI：10.13241/j.cnki.pmb.2022.18.017 |
| 中文关键词: 上皮性卵巢癌 卡铂 耐药 CA125 IGF1 Annexin A3 HE4 预后 |
| 英文关键词: Epithelial ovarian cancer Carboplatin Drug resistance CA125 IGF1 Annexin A3 HE4 Prognosis |
| 基金项目:湖北省卫生计生委联合基金项目（WJ2018H0089） |
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| 中文摘要: |
| 摘要 目的：研究上皮性卵巢癌（EOC）患者血清癌抗原125（CA125）、胰岛素生长因子1（IGF1）、膜联蛋白A3（Annexin A3）、人附睾蛋白4（HE4）与卡铂耐药和预后的关系。方法：选取2015年4月～2018年4月期间中部战区总医院收治的100例EOC患者，均接受以卡铂为主的化疗方案治疗，将其按照是否出现卡铂耐药分成耐药组25例及无耐药组75例。检测并比较两组血清CA125、IGF1、Annexin A3、HE4水平，比较两组的基线资料，通过多因素Logistic回归分析EOC患者卡铂耐药的影响因素。此外，对所有患者均进行3年随访，根据预后差异将其分为死亡组49例和存活组51例，比较两组血清CA125、IGF1、Annexin A3、HE4水平差异。结果：耐药组血清CA125、IGF1、Annexin A3、HE4水平均高于无耐药组（P＜0.05）。耐药组FIGO分期为Ⅲ～Ⅳ期的人数占比高于无耐药组（P＜0.05）。多因素Logistic回归分析结果显示：血清CA125、IGF1、Annexin A3、HE4水平较高以及FIGO分期Ⅲ～Ⅳ期是EOC患者卡铂耐药的危险因素（P＜0.05）。死亡组血清CA125、IGF1、Annexin A3、HE4水平均高于存活组（P＜0.05）。结论：血清CA125、IGF1、Annexin A3、HE4水平升高是EOC患者卡铂耐药的影响因素，并可能与EOC患者预后不良有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum cancer antigen 125 (CA125), insulin growth factor 1 (IGF1), Annexin A3, human epididymal protein 4 (HE4) and carboplatin resistance and prognosis in patients with epithelial ovarian cancer (EOC). Methods: 100 patients with EOC who were admitted to Central Theater General Hospital from April 2015 to April 2018 were selected, all patients were treated with carboplatin based chemotherapy. They were divided into drug-resistant group with 25 cases and non drug-resistant group with 75 cases according to whether there was carboplatin resistance. The levels of serum CA125, IGF1, Annexin A3 and HE4 in the two groups were detected and compared. The baseline data of the two groups were compared. The influencing factors of carboplatin resistance in patients with EOC were analyzed by multivariate Logistic regression. In addition, all patients were followed up for 3 years. According to the difference of prognosis, they were divided into 49 cases in the death group and 51 cases in the survival group. The levels of serum CA125, IGF1, Annexin A3 and HE4 were compared between the two groups. Results: The levels of serum CA125, IGF1, Annexin A3 and HE4 in drug-resistant group were higher than those in non drug-resistant group (P＜0.05). The proportion of FIGO stage Ⅲ ~ Ⅳ stage in drug-resistant group was higher than that in non drug-resistant group (P＜0.05). Multivariate Logistic regression analysis showed that the high levels of serum CA125, IGF1, Annexin A3 and HE4 and FIGO stage Ⅲ ~ Ⅳ were the risk factors of carboplatin resistance in patients with EOC(P＜0.05). The levels of serum CA125, IGF1, Annexin A3 and HE4 in the death group were higher than those in the survival group(P＜0.05). Conclusion: The elevated levels of serum CA125, IGF1, Annexin A3 and HE4 are the influencing factors of carboplatin resistance in patients with EOC, and which may be related to the poor prognosis of patients with EOC. |
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