| 王桂华,戴 莹,阮光萍,曾婷婷,张 绎,郭 俊.单采富含血小板血浆治疗膝关节骨性关节炎疗效分析[J].,2022,(17):3333-3337 |
| 单采富含血小板血浆治疗膝关节骨性关节炎疗效分析 |
| Effect of Platelet Rich Plasma on Knee Osteoarthritis |
| 投稿时间：2022-04-11 修订日期：2022-04-30 |
| DOI：10.13241/j.cnki.pmb.2022.17.026 |
| 中文关键词: 单采 富含血小板血浆 膝关节骨性关节 膝关节功能 |
| 英文关键词: Single mining Platelet rich plasma Knee osteoarthritis Knee function |
| 基金项目:云南省重点项目（2018FA041/202101AS070039）；联勤保障部队第920医院院内科技计划（2020YGB13） |
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| 中文摘要: |
| 摘要 目的：探讨单采富含血小板血浆治疗膝关节骨性关节炎的治疗效果。方法：选取我院2019年10月到2021年10月收治的100例膝关节骨性关节炎患者作为研究对象，将所有患者依照随机分为联合组与对照组，各50例。对照组患者采取常规股神经脉冲射频术治疗，联合组在对照组基础上增加单采富含血小板血浆治疗，对比两组患者的近远期膝关节疼痛程度，治疗前后白细胞介素-6（IL-6）、白细胞介素-1（IL-1）、肿瘤坏死因子-α（TNF-α）表达水平，膝关节功能以及不良反应情况。结果：治疗后1个月、治疗后6月、治疗后1年两组患者视觉模拟量表（VAS）评分逐渐降低，且联合组低于对照组（P＜0.05）；两组患者治疗前IL-6、IL-1、TNF-α相关炎症因子水平对比无差异（P＞0.05），治疗后水平均降低，且联合组较对照组低（P＜0.05）；治疗前两组患者膝关节主观（IKDC）评分、膝关节功能（Lysholm）评分对比无明显差异（P＞0.05），治疗后两组患者IKDC评分、Lysholm评分均明显降低，且联合组较对照组低（P＜0.05）；两组患者不良反应对比无差异（P＞0.05）。结论：膝关节骨性关节炎患者在常规治疗基础上增加单采富含血小板血浆治疗能够减轻患者近远期疼痛感，降低患者机体炎症反应，提升膝关节功能，且安全性较高，值得临床应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the therapeutic effect of platelet rich plasma in the treatment of knee osteoarthritis. Methods: 100 patients with knee osteoarthritis treated in our hospital from October 2019 to October 2021 were selected as the research object. All patients were randomly divided into joint group and matched group, with 50 cases in each group. The patients in the matched group were treated with routine femoral nerve meridian impulse radiofrequency therapy, and the joint group was treated with platelet rich plasma on the basis of the matched group. The short-term and long-term knee pain degree, interleukin-6 (IL-6), interleukin-1 (IL-1) and tumor necrosis factor before and after treatment were compared between the two groups-α （TNF-α） Expression level, knee range of motion and knee function. Results: The scores of visual analogue scale (VAS) in the two groups decreased gradually 1 month, 6 years and 1 year post-treatment, and the scores in the joint group were lower than those in the matched group (P<0.05); IL-6, IL-1 and TNF- α in the two groups pretherapy was no difference in the levels of related inflammatory factors (P>0.05). Post-treatment, the levels of related inflammatory factors in the joint group were lower than those in the matched group (P<0.05); Pretherapy, there was no difference in knee subjective (IKDC) score and knee function (Lysholm) score between the two groups (P>0.05). Post-treatment, the IKDC score and Lysholm score of the two groups decreased, and the joint group was lower than that of the matched group (P<0.05); There was no difference in adverse reactions between the two groups (P>0.05). Conclusion: On the basis of routine treatment, adding platelet rich plasma to patients with knee osteoarthritis can reduce the short-term and long-term pain, reduce the body inflammatory response, and improve the range of motion and function of knee joint, which is worthy of clinical application and promotion. |
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