| 周 帅,王 珂,贺加星,杨小军,杨 平.血清PG、LGR4与胃癌患者腹腔镜D2根治术预后相关性分析[J].,2022,(16):3051-3054 |
| 血清PG、LGR4与胃癌患者腹腔镜D2根治术预后相关性分析 |
| Correlation Analysis of Serum PG, LGR4 and Prognosis of Gastric Cancer Patients Undergoing Laparoscopic D2 Radical Resection |
| 投稿时间：2022-02-05 修订日期：2022-02-27 |
| DOI：10.13241/j.cnki.pmb.2022.16.011 |
| 中文关键词: 腹腔镜D2根治术 胃癌 胃蛋白酶原 多富含亮氨酸重复单位的G蛋白偶联受体4 |
| 英文关键词: Laparoscopic D2 radical resection Gastric cancer Pepsinogen Multi-leucine-rich repeat unit G protein-coupled receptor 4 |
| 基金项目:陕西省社会发展科技攻关项目（2016SF-103） |
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| 摘要 目的：探讨与分析血清胃蛋白酶原（PG）、多富含亮氨酸重复单位的G蛋白偶联受体4（LGR4）与胃癌患者腹腔镜D2根治术（LD2RS）预后相关性。方法：2021年1月到2021年12月选择在本院进行诊治的胃癌患者210例作为胃癌组，同期选择在本院进行体检的健康者210例作为对照组。检测两组人群的血清血清PG、LGR4含量，调查患者预后并进行相关性分析。结果：胃癌组的血清PGⅠ含量低于对照组，血清LGR4、PG Ⅱ含量高于对照组（P<0.05）。平均手术时间154.98±19.43 min；平均术中出血量148.62±15.83 mL；平均术后肠功能恢复时间2.51±0.29 d；平均术后肛门排气时间2.79±0.16 d；平均术后下床活动时间2.33±0.15 d；平均术后住院时间9.28±0.29 d。术后14 d发生并发症24例，占比11.4 %。胃癌组所有患者随访至今，平均随访时间为17.38±2.15个月，预后发生转移23例，占比11.0 %；复发14例，占比6.7 %。Spearsman分析显示胃癌患者预后转移、复发与血清PGⅠ、PGⅡ、LGR4含量存在相关性（P<0.05）。多因素logistic回归显示血清PGⅠ、PGⅡ、LGR4为导致患者预后复发、转移的重要因素（P<0.05）。结论：腹腔镜D2根治术治疗胃癌具有很好的安全性与微创性，但是预后复发率与转移率依然比较高，血清PG、LGR4与胃癌患者腹腔镜D2根治术预后存在相关性，也是导致预后复发与转移的重要因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate and analysis the correlation analysis of serum pepsinogen (PG), leucine rich repeat containing G protein coupled receptor 4 (LGR4) and prognosis of gastric cancer patients undergoing laparoscopic D2 radical resection (LD2RS). Methods: From January 2021 to December 2021, 210 cases of gastric cancer patients who were diagnosed and treated in Second Affiliated Hospital of Air Force Military Medical University were selected as the gastric cancer group, and during the same period, 210 healthy subjects who underwent physical examination in our hospital were selected as the control group. The serum levels of PG and LGR4 in the two groups were detected, and the prognosis of the patients were investigated and correlation analysis were performed. Results: The content of serum PG Ⅰ in gastric cancer group were lower than that in control group(P<0.05), while the content of serum LGR4 and PG II in gastric cancer group were higher than that in control group(P<0.05). The mean operation time in the all patients were 154.98±19.43 min; the mean intraoperative blood loss were 148.62±15.83 mL; the mean postoperative bowel function recovery time were 2.51±0.29 d; the mean postoperative anal exhaust time were 2.79±0.16 d; the mean postoperative ambulation time were 2.33 ±0.15 d; average postoperative hospital stay were 9.28±0.29 d. There were 24 cases of complications were occurred at 14 days after operation that accounted for 11.4 %. All the patients in the gastric cancer group were followed up so far, with an average follow-up time of 17.38±2.15 months. The prognosis were 23 cases of metastasis, accounted for 11.0 %; 14 cases of recurrence, accounted for 6.7 %. Spearsman analysis showed that the prognosis metastasis and recurrence of gastric cancer patients were correlated with the levels of serum PGⅠ, PGⅡ, LGR4 (P<0.05). Conclusion: Laparoscopic D2 radical resection for gastric cancer is safe and minimally invasive, but the prognosis of recurrence and metastasis rates is still relatively high. The serum PG and LGR4 are associated with the prognosis of gastric cancer patients undergoing laparoscopic D2 radical resection, and are also important factors leading to the prognosis of recurrence and metastasis. |
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