| 朱英超,吴晴伟,许晨婕,孙艺渊,蒋莉莉.阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍现状调查及与生活质量的相关性研究[J].,2022,(16):3036-3040 |
| 阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍现状调查及与生活质量的相关性研究 |
| Status Survey of Cognitive Impairment in Patients with Obstructive Sleep Apnea Hypopnea Syndrome and its Correlation with Quality of Life |
| 投稿时间：2022-02-06 修订日期：2022-02-28 |
| DOI：10.13241/j.cnki.pmb.2022.16.008 |
| 中文关键词: 认知功能障碍 现状调查 阻塞性睡眠呼吸暂停低通气综合征 相关性 生活质量 |
| 英文关键词: Cognitive impairment Status survey Obstructive Sleep Apnea Hypopnea Syndrome Correlation Quality of Life |
| 基金项目:上海市科委自然科学基金项目（14ZR1423800） |
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| 摘要 目的：调查阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者认知功能障碍的发生情况并分析其影响因素及与生活质量的相关性。方法：选取2019年5月至2021年5月我院收治的190例OSAHS患者，运用蒙特利尔认知评估量表（MoCA）评估其认知功能，并根据结果将患者分为正常组和认知障碍组。比较两组患者的多导睡眠监测（PSG）指标，采用单因素、多因素Logistic 回归分析OSAHS患者发生认知功能障碍的影响因素，比较两组患者的睡眠呼吸暂停生活质量指数（SAQLI）评分，采用Pearson相关系数分析MoCA评分与SAQLI评分的相关性。结果：190例OSAHS患者中有77例存在认知功能障碍，发生率为40.53%。认知障碍组患者的平均血氧饱和度（MSaO2）低于正常组患者（P<0.05）。单因素分析结果显示，认知障碍组与正常组之间年龄、体育锻炼频率、受教育年限、体质量指数（BMI）比较有统计学差异（P<0.05）。多因素Logistic回归分析结果显示，年龄≥50岁、BMI≥28.0 kg/m2、受教育年限<9年、体育锻炼频率低于每周2次、MSaO2<93%是OSAHS患者发生认知功能障碍的危险因素（P<0.05）。认知障碍组患者SAQLI三个维度（日常生活、社会交往、症状）的评分以及总分均低于正常组患者（P<0.05）。OSAHS患者的MoCA评分与日常生活、社会交往、症状评分以及SAQLI总分均呈正相关（P<0.05）。结论：OSAHS患者的认知功能障碍发生率较高，年龄、BMI、受教育年限、体育锻炼频率以及MSaO2均是其影响因素，OSAHS患者的生活质量与认知功能呈正相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the incidence of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and analyze its influencing factors and correlation with quality of life. Methods: A total of 190 patients with OSAHS who were treated in our hospital from May 2019 to May 2021 were selected. Cognitive function was assessed using the Montreal Cognitive Assessment Scale (MoCA), and patients were divided into normal group and cognitive impairment group according to the results. Polysomnography monitoring (PSG) indexes of patients in the two groups were compared. The influencing factors of cognitive impairment in patients with OSAHS were analyzed by univariate and multivariate Logistic regression, and the sleep apnea quality of life index (SAQLI) scores of patients in the two groups were compared. Pearson correlation coefficient was used to analyze the correlation between MoCA score and SAQLI score. Results: There were 77 cases of cognitive impairment in 190 patients with OSAHS, with an incidence of 40.53%. The mean blood oxygen saturation(MSaO2) in the cognitive impairment group was lower than that in the normal group (P<0.05). Univariate analysis showed that there were significant differences in age, physical exercise frequency, years of education and body mass index (BMI) between the cognitive impairment group and the normal group(P<0.05). Multivariate Logistic regression analysis showed that age ≥50 years, BMI≥28.0 kg/m2, years of education <9 years, physical exercise frequency less than twice a week and MSaO2<93% were risk factors for cognitive impairment in patients with OSAHS(P<0.05). The SAQLI score and total score of the three dimensions (daily life, social interaction and symptoms) in the cognitive impairment group were lower than those in the normal group (P<0.05). MoCA score of patients with OSAHSwas positively correlated with daily life, social interaction, symptom score and SAQLI total score(P<0.05). Conclusion: The patients with OSAHS have a high incidence of cognitive impairment, and age, BMI, years of education, physical exercise frequency and MSaO2 are all influencing factors. The quality of life of patients with OSAHS is positively correlated with cognitive function. |
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