| 曾凡勇,曾 旭,李 君,蔡建国,李文华.对比增强高分辨率MRI评价大脑中动脉斑块与脑脊液炎性因子水平的相关性[J].,2022,(15):2875-2878 |
| 对比增强高分辨率MRI评价大脑中动脉斑块与脑脊液炎性因子水平的相关性 |
| Contrast-enhanced high-resolution MRI to Evaluate the Correlation between Middle Cerebral Artery Plaque and Cerebrospinal Fluid Inflammatory Factors |
| 投稿时间：2021-12-23 修订日期：2022-01-18 |
| DOI：10.13241/j.cnki.pmb.2022.15.014 |
| 中文关键词: 磁共振成像 动脉斑块 脑脊液 炎症因子 |
| 英文关键词: Magnetic resonance imaging Arterial plaque Cerebrospinal fluid Inflammatory factor |
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| 中文摘要: |
| 摘要 目的：研究对比增强高分辨磁共振成像（MRI）评价的大脑动脉斑块与脑脊液中炎症因子水平的相关性。方法：选择2017年1月到2021年6月在我院接受治疗的脑梗死患者70例，根据其病情分为急性脑梗死组（ACI）（n=30）和非急性脑梗死组（No-ACI）（n=40），所有患者均行颅脑磁共振检测，比较两组患者T1加权成像（T1WI）、T2加权成像（T2WI）以及T1加权成像增强（T1WI+E）斑块信号和强化程度，并比较两组患者或不同MRI表现患者脑脊液人肿瘤坏死因子-α（TNF-α）和人白介素-6（IL-6）水平。结果：ACI组和No-ACI组脑梗死患者在T1WI和T2WI上低信号、等信号和高信号比例无显著差异（P>0.05）；而ACI组患者在T2WI+E上大脑动脉斑块无强化和轻度强化患者比例显著低于No-ACI组患者（P<0.05），明显强化患者比例显著高于No-ACI组患者（P<0.05）。ACI组患者脑脊液TNF-α和IL-6水平显著高于No-ACI组患者。在T2WI+E上，轻度强化脑梗死患者TNF-α和IL-6含量显著高于无强化脑梗死患者（P<0.05），而显著低于明显强化组脑梗死患者（P<0.05）。结论：对比增强高分辨率MRI可有效评估大脑动脉斑块特征，并且大脑动脉斑块强化程度与脑积液炎症因子水平密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between cerebral artery plaques evaluated by contrast-enhanced high-resolution magnetic resonance image (MRI) and the levels of inflammatory factors in cerebrospinal fluid. Methods: 70 patients with cerebral infarction who were treated in our hospital from January 2017 to June 2021 were selected and divided into acute cerebral infarction group (ACI) (n=30) and non-acute cerebral infarction group (No-ACI) according to their condition (N=40), all patients underwent cranial magnetic resonance detection, and compared the two groups of patients with T1 weighted image (T1 Weighted image, T1WI), T2 weighted image (T2 Weighted image, T2WI) and T1 weighted image enhancement (T1 Weighted image) enhanced, T1WI+E) plaque signal and degree of enhancement, and compare the levels of TNF-α and IL-6 in the cerebrospinal fluid of the two groups of patients or patients with different MRI findings. Results: There was no difference in the proportions of low signal, iso-signal and high signal on T1WI and T2WI in patients with cerebral infarction in the ACI group and No-ACI group (P>0.05); while in the ACI group, there was no enhancement and mild cerebral artery plaque on T2WI+E. The proportion of patients with high degree of enhancement was lower than that of patients in the No-ACI group (P<0.05), and the proportion of patients with enhancement was higher than that of patients in the No-ACI group(P<0.05). The levels of TNF-α and IL-6 in the cerebrospinal fluid of the ACI group were higher than those of the No-ACI group. On T2WI+E, the levels of TNF-α and IL-6 in patients with mildly enhanced cerebral infarction were higher than those in patients with non-enhanced cerebral infarction(P<0.05), and lower than those in patients with enhanced cerebral infarction(P<0.05). Conclusion: Contrast-enhanced high-resolution MRI can effectively assess the characteristics of cerebral artery plaque, and the degree of cerebral artery plaque enhancement is closely related to the level of inflammatory factors in cerebral effusion. |
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