| 王 娟,祁国星,宋化雨,李建辉,母 苓.早发性卵巢功能不全患者血清25-OH-VD、DBP、SIRT1与性激素和氧化应激的关系研究[J].,2022,(14):2796-2800 |
| 早发性卵巢功能不全患者血清25-OH-VD、DBP、SIRT1与性激素和氧化应激的关系研究 |
| Study of Serum 25-OH-VD, DBP, SIRT1 in Relation to Sex Hormones and Oxidative Stress in Patients with Early-Onset Ovarian Insufficiency |
| 投稿时间：2022-02-27 修订日期：2022-03-22 |
| DOI：10.13241/j.cnki.pmb.2022.14.039 |
| 中文关键词: 早发性卵巢功能不全 25-OH-VD DBP SIRT1 性激素 氧化应激 |
| 英文关键词: Premature ovarian insufficiency 25-OH-VD DBP SIRT1 Sex hormones Oxidative stress |
| 基金项目:四川省教育厅科研基金项目（16ZB04813） |
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| 中文摘要: |
| 摘要 目的：探讨早发性卵巢功能不全（POI）患者血清25-羟基维生素D（25-OH-VD）、邻苯二甲酸二丁酯（DBP）、沉默信息调节因子2相关酶1（SIRT1）与性激素和氧化应激的关系。方法：选取2019年1月～2020年12月攀枝花学院附属医院妇产科收治的97例POI患者（POI组），另选取同期54名体检健康女性（对照组）。检测两组血清性激素[卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）、抗缪勒管激素（AMH）]、氧化应激[超氧化物岐化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）]、25-OH-VD、DBP、SIRT1水平。采用Pearson/Spearman相关系数分析POI患者血清25-OH-VD、DBP、SIRT1与性激素、氧化应激指标的相关性，Logistic回归分析血清25-OH-VD、DBP、SIRT1与POI的关系。结果：POI组FSH、LH、MDA、DBP水平高于对照组，E2、AMH、SOD、GSH-Px、25-OH-VD、SIRT1水平低于对照组（P＜0.05）。Pearson/Spearman相关系数显示，POI患者血清25-OH-VD、SIRT1与FSH、LH、MDA呈负相关，与E2、AMH、SOD、GSH-Px呈正相关（P＜0.05）；血清DBP与FSH、LH、MDA呈正相关，与E2、AMH、SOD、GSH-Px呈负相关（P＜0.05）。Logistic回归分析显示，调整混杂因素后，25-OH-VD（OR＝0.825，95％CI：0.741～0.919）、SIRT1（OR＝0.872，95％CI：0.810～0.938）是POI发生的保护因素，DBP（OR＝1.173，95％CI：1.074～1.282）是危险因素（P＜0.05）。结论：POI患者血清25-OH-VD、SIRT1水平下调，DBP水平上调，与性激素和氧化应激相关，可能成为POI的辅助预测因子。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum 25-hydroxy vitamin D (25-OH-VD), dibutyl phthalate (DBP), silent information regulator factor 2-related enzyme 1 (SIRT1) and sex hormones and oxidative stress in patients with premature ovarian insufficiency (POI). Methods: A total of 97 POI patients (POI group) who were admitted to the Department of Obstetrics and Gynecology, Affiliated Hospital of Panzhihua University from January 2019 to December 2020 were selected, and 54 healthy women (control group) were selected during the same period. Serum sex hormones [follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-Müllerian hormone (AMH)], oxidative stress [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA)], 25-OH-VD, DBP, SIRT1 levels were measured in both groups. Pearson/Spearman correlation coefficients were used to analyze the correlation between serum 25-OH-VD, DBP and SIRT1 and sex hormones and oxidative stress indicators in POI patients, and Logistic regression was used to analyze the relationship between serum 25-OH-VD, DBP and SIRT1 and POI. Results: The levels of FSH, LH, MDA and DBP in the POI group were higher than those in the control group, and the levels of E2, AMH, SOD, GSH-Px, 25-OH-VD and SIRT1 were lower than those in the control group (P<0.05). Pearson/Spearman correlation coefficients showed that serum 25-OH-VD and SIRT1 were negatively correlated with FSH, LH and MDA and positively correlated with E2, AMH, SOD and GSH-Px in POI patients (P<0.05). serum DBP was positively correlated with FSH, LH and MDA and negatively correlated with E2, AMH, SOD and GSH-Px (P<0.05). Logistic regression analysis showed that after adjusting for confounders, 25-OH-VD (OR＝0.825, 95％CI: 0.741～0.919) and SIRT1 (OR＝0.872，95％CI: 0.810～0.938) were independent protective factors for the occurrence of POI, and DBP (OR＝1.173, 95％CI: 1.074～1.282) was an independent risk factor (P<0.05). Conclusion: Serum 25-OH-VD and SIRT1 levels are downregulated and DBP levels are upregulated in patients with POI, which are associated with sex hormones and oxidative stress and may be predictors of POI. |
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