| 孙运坡,金秉巍,应学翔,金艳凤,沈容荣.Luminal B型乳腺癌不同亚型的临床病理特征及预后生存分析[J].,2022,(12):2366-2371 |
| Luminal B型乳腺癌不同亚型的临床病理特征及预后生存分析 |
| Clinicopathological Features, Prognosis and Survival Analysis of Different Subtypes of Luminal B Type Breast Cancer |
| 投稿时间：2022-01-07 修订日期：2022-01-30 |
| DOI：10.13241/j.cnki.pmb.2022.12.034 |
| 中文关键词: 乳腺癌 Luminal B型 人表皮生长受体2 病理特征 预后 影响因素 |
| 英文关键词: Breast cancer Luminal B type Human epidermal growth receptor 2 Pathological features Prognosis Influencing factors |
| 基金项目:上海交通大学附属第六人民医院院级课题（DY2019013）；中国高校医学期刊临床专项基金项目（11321394） |
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| 中文摘要: |
| 摘要 目的：分析Luminal B型乳腺癌不同亚型患者的临床病理特征以及预后差异。方法：回顾性分析2006年1月至2016年1月期间上海市第六人民医院徐汇院区和临港院区收治的359例原发性Luminal B型乳腺癌患者的临床病理以及随访资料，根据Luminal B型乳腺癌分子亚型分为人表皮生长受体2（Her-2）阴性组（266例）和Her-2阳性组（93例）。比较两组患者的临床病理特征差异。绘制Kaplan-Meier生存曲线，分析两组患者5年无进展生存率和总生存率的差异，采用Cox风险比例回归分析Luminal B型乳腺癌患者预后的影响因素。结果：Her-2阳性组TNM分期Ⅲ～Ⅳ期、肿瘤组织学分级Ⅲ级、PR阴性、Ki-67高表达、淋巴结转移比例高于Her-2阴性组（P＜0.05）。Her-2阳性组5年DFS、OS生存率分别为12.90%、40.86%，分别低于Her-2阴性组的24.06%、59.77%（Log-Rankχ2=14.500、12.860，P=0.000、0.000）。TNM分期Ⅲ～Ⅳ期、淋巴结转移、Her-2阳性、PR阴性是Luminal B型乳腺癌患者不良预后的危险因素（P＜0.05）。结论：Luminal B 型乳腺癌患者不同分子亚型的TNM分期、肿瘤组织学分级、淋巴结转移、Ki-67和PR表达存在差异，同时，TNM分期、淋巴结转移、Her-2阳性、PR阴性是Luminal B 型乳腺癌患者预后不良的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinicopathological features and prognosis difference of Luminal B type breast cancer patients with different subtypes. Methods: The clinicopathological and follow-up data of 359 cases of primary Luminal B type breast cancer patients who were admitted to Xuhui And Lingang Hospitals of Shanghai Sixth People's Hospital from January 2006 to January 2016 were retrospectively analyzed. According to Luminal B type breast cancer molecular subtypes, the patients were divided into the human epidermal growth receptor 2 (Her-2) negative group (266 cases) and the Her-2 positive group (93 cases). The clinicopathological features difference of the two groups were compared. Kaplan-meier survival curve was drawn to analyze the difference of 5-year progression-free survival rate and overall survival rate between the two groups, and Cox proportional regression was used to analyze the influencing factors of the prognosis of Luminal B type breast cancer patients. Results: TNM stage Ⅲ～Ⅳ stage, tumor histological grade Ⅲ grade, PR negative, Ki-67 high expression and lymph node metastasis proportion in Her-2 positive group were higher than those in Her-2 negative group (P＜0.05). The 5-year DFS and OS survival rates in Her-2 positive group were 12.90% and 40.86%, respectively, which were lower than 24.06% and 59.77% in Her-2 negative group (Log-Rank χ2=14.500, 12.860, P=0.000, 0.000). TNM stage Ⅲ～Ⅳ stage, lymph node metastasis, Her-2 positive and PR negativewere the risk factors for poor prognosis in Luminal B type breast cancer patients (P＜0.05). Conclusion: There are differences in TNM stage, tumor histological grade, lymph node metastasis, Ki-67 and PR expression in different molecular subtypes of Luminal B type breast cancer patients. Meanwhile, TNM stage, lymph node metastasis, Her-2 positive and PR negative are risk factors for poor prognosis in Luminal B type breast cancer patients. |
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