| 梁 丽,李 丹,王 利,张 磊,任晓艳,张 伟,谢劲松.慢性阻塞性肺疾病患者中血清亲环素A、趋化因子CX3CL1表达水平及临床意义[J].,2022,(12):2260-2264 |
| 慢性阻塞性肺疾病患者中血清亲环素A、趋化因子CX3CL1表达水平及临床意义 |
| Expression Level and Clinical Significance of Serum Cyclophilin A and Chemokine CX3CL1 in Patients with Chronic Obstructive Pulmonary Disease |
| 投稿时间：2021-12-05 修订日期：2021-12-27 |
| DOI：10.13241/j.cnki.pmb.2022.12.012 |
| 中文关键词: 慢性阻塞性肺疾病 亲环素A 趋化因子CX3CL1 炎性指标 肺功能 |
| 英文关键词: Chronic obstructive pulmonary disease Cyclophilin A Chemokine CX3CL1 Inflammatory index Lung function |
| 基金项目:江苏省卫生计生委医学科研项目（H20160181） |
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| 中文摘要: |
| 摘要 目的：探讨慢性阻塞性肺疾病（COPD）患者中血清亲环素A（CyPA）、趋化因子CX3CL1以及其他炎性指标的表达水平及其临床意义。方法：选取2019年1月-2021年6月本院收治的COPD患者120例作为研究对象，其中68例患者为急性加重期组，52例患者为稳定期组；另选取体检健康者45例作为对照组。收集所有受试者的临床资料，检测其血清中CyPA、CX3CL1、C反应蛋白（CRP）、白细胞介素-6（IL-6）以及基质金属蛋白酶-9（MMP-9）水平，比较3组患者各参数的差异，并与肺功能进行相关性分析，比较急性加重期患者治疗前后各指标的差异。结果：急性加重期组患者的血清 CyPA、CX3CL1、CRP、IL-6、MMP-9水平均明显高于稳定期组和对照组患者，稳定期组患者的血清 CyPA、CX3CL1、CRP、IL-6、MMP-9水平均明显高于对照组患者（均P＜0.05）；而急性加重期组患者的第1s用力呼气量（FEV1）、用力肺活量（FVC）、第1s用力呼气量（FEV1）与用力肺活量（FVC）的比值（FEV1%）、最大呼气峰流速（PEF）以及最大呼气中期流速（MMEF）明显低于稳定期组和对照组患者，稳定期组患者的FEV1、FVC、FEV1/FVC、PEF、MMEF明显低于对照组患者（均P＜0.05）。COPD患者的血清CyPA、CX3CL1、CRP、IL-6、MMP-9水平与FEV1、FVC、FEV1/FVC、PEF、MMEF呈负相关（P<0.05）。与治疗前相比较，急性加重期组患者在治疗后血清CyPA、CX3CL1、CRP、IL-6、MMP-9水平明显下降，而FEV1、FVC、FEV1/FVC、PEF、MMEF明显上升（均P＜0.05）。结论：COPD患者的血清CyPA、CX3CL1、CRP、IL-6、MMP-9水平可在一定程度上预测患者的严重程度，同时也可以作为急性加重期治疗后效果的评价指标。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression levels of serum cyclophilin A (CyPA), chemokine CX3CL1 and other inflammatory indicators in patients with chronic obstructive pulmonary disease (COPD) and their clinical significance. Methods: A total of 120 COPD patients admitted to our hospital from January 2019 to June 2021 were selected as the research objects, of which 68 patients were in the acute exacerbation group 52 patients were in the stable group, and 45 healthy patients were selected as the control group. Collected the clinical data of all subjects, and detect the levels of CyPA, CX3CL1, C-reactive protein (CRP), interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) in their serum, and compared the parameters of the three groups of patients differences,and correlation analysis with lung function,compared the differences of various indicators before and after treatment in patients with acute exacerbations. Results: The serum levels of CyPA, CX3CL1, CRP, IL-6 and MMP-9 in the acute exacerbation group were significantly higher than those in the stable group and the control group, and the serum levels of CyPA, CX3CL1, CRP, IL-6 and MMP-9 in the stable group were significantly higher than those in the control group (all P<0.05); The forced expiratory volume in first second(FEV1), forced vital capacity(FVC), forced expiratory volume in first second/forced vital capacity(FEV1/FVC), peak expiratory flow(PEF) and maximal midexpiratory flow(MMEF) of patients in acute exacerbation group were significantly lower than those in stable group and control group,and the FEV1, FVC, FEV1/FVC, PEF and MMEF of patients in stable group were significantly lower than those in control group (all P<0.05). The levels of serum CyPA, CX3CL1, CRP, IL-6 and MMP-9 in patients with COPD were negatively correlated with FEV1, FVC, FEV1/FVC, PEF and MMEF (P<0.05). Compared with before treatment, the levels of serum CyPA, CX3CL1, CRP, IL-6 and MMP-9 in the acute exacerbation group decreased significantly after treatment, while FEV1, FVC, FEV1/FVC, PEF and MMEF increased significantly (all P<0.05). Conclusion: The levels of serum CyPA, CX3CL1, CRP, IL-6 and MMP-9 in patients with COPD can predict the severity of patients to a certain extent, and can also be used as an evaluation index of the effect after treatment in acute exacerbation stage. |
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