| 李 莉,王 平,邓 洁,张晓芳,万 露.复发卵巢成人型颗粒细胞瘤的临床特点及复发的影响因素分析[J].,2022,(12):2245-2249 |
| 复发卵巢成人型颗粒细胞瘤的临床特点及复发的影响因素分析 |
| Analysis of Clinical Characteristics and Recurrence Factors of Recurrent Adult Granulosa Cell Tumor of Ovary |
| 投稿时间：2021-12-23 修订日期：2022-01-18 |
| DOI：10.13241/j.cnki.pmb.2022.12.009 |
| 中文关键词: 卵巢成人型颗粒细胞瘤 复发 影响因素 肿瘤破裂 多因素分析 |
| 英文关键词: Adult grannulosa cell tumor Recurrence Influencing factors Tumor rupture Multivariate analysis |
| 基金项目:四川省科技厅重点研发项目（2021YFS0015） |
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| 中文摘要: |
| 摘要 目的：探讨复发卵巢成人型颗粒细胞瘤（AGCT）的临床特点及复发的影响因素。方法：回顾性分析我院收治的24例复发AGCT患者的临床资料。结果：2014年1月-2021年12月在四川大学华西第二医院共收治卵巢成人型颗粒细胞瘤的患者97例，复发AGCT患者24例，复发率24.7 %。初次复发距离初次治疗的中位间隔时间为69个月（24月-144月）。24例复发AGCT初发平均年龄42.8岁（24岁-60岁）。初诊时肿瘤最大直径<10 cm 15例，肿瘤最大直径≥10 cm 9例。初次FIGO分期：I期14例，占58.3 %，II期3例，占12.5 %，III期7例，占29.1 %。I期患者中肿瘤破裂8例。所有病例初次治疗时均接受手术治疗。保留生育功能手术8例，接受非保留生育功能的手术16例。初次手术后14例患者接受了化疗，其中I期患者14例，有4例接受辅助化疗，有10例术后未接受辅助化疗。复发后有7例患者发生多次复发。Cox回归模型分析显示FIGO分期、I期患者肿瘤破裂为导致复发卵巢成人型颗粒细胞瘤复发的危险因素（P<0.05）。结论：AGCT为低度恶性肿瘤，有远期复发和多次复发的风险，FIGO分期是影响复发的因素，晚期的患者更易复发。对于部分临床早期患者，肿瘤破裂也会增加复发的风险。AGCT患者需长期随访。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical characteristics and recurrence factors of recurrencet adult granulosa cell tumor of ovary (AGCT). Methods: The clinicopathological data of 24 patients with recurrencet adult granulosa cell tumor of ovary admitted to our hospital were retrospectively analyzed. Results: A total of 97 patients with adult granulosa cell tumor of ovary were admitted to The Second West China Hospital of Sichuan University from January 2014 to December 2021, and 24 patients had recurrenct AGCT, with the recurrence rate was 24.7 %. The median interval between the first relapse and the first treatment was 69 months(24-144months). The mean age of initial onset of the 24 recurrent AGCT patients was 48.2 years(24-60years). At initial diagnosis, the maximum tumor diameter was less than 10 cm in 15 cases and more than 10 cm in 9 cases. Initial FIGO staging: 14 cases(58.3 %) in stageI, 3 cases(12.5 %) in stage II, and 7 cases(29.1 %) in stage III. Tumor rupture occurred in 8 cases in stage I. All patients were treated with surgery during initial treatment. There were 8 cases of fertility preservation operation and 16 cases of non-fertilitity preservation operation. Fourteen patients received chemotherapy after primary surgery, including 14 stage I patients. 4 patients received adjuvant chemotherapy, and 10 patients did not receive adjuvant chemotherapy after surgery. Seven patients had multiple relapses after recurrence. Cox regression model analysis showed that FIGO stage and tumor rupture in patients with stage I were the risk factors for the recurrence of recurrent adult granulosa cell tumor of the ovary (P<0.05). Conclusion: FIGO stage is a factor affecting recurrence, and patients with advanced stage are more likely to relapse. FIGO stage is a facter affecting recurrence, and also increase the risk of recurrence. Patients with AGCT need long-term follow-up. |
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