| 贾丽媛,王 丽,温 丽,翟小颖,梁玉丽.急性淋巴细胞白血病患儿血清25羟维生素D3、乳酸脱氢酶、白细胞介素-6水平与危险度分层和预后不良的关系研究[J].,2022,(11):2166-2170 |
| 急性淋巴细胞白血病患儿血清25羟维生素D3、乳酸脱氢酶、白细胞介素-6水平与危险度分层和预后不良的关系研究 |
| Relationship between Serum 25 Hydroxyvitamin D3, Lactate Dehydrogenase and Interleukin-6 Levels and Risk Stratification and Prognosis in Children with Acute Lymphoblastic Leukemia |
| 投稿时间：2022-01-23 修订日期：2022-02-18 |
| DOI：10.13241/j.cnki.pmb.2022.11.033 |
| 中文关键词: 急性淋巴细胞白血病 25羟维生素D3 乳酸脱氢酶 白细胞介素-6 危险度分层 预后 |
| 英文关键词: Acute lymphoblastic leukemia 25 hydroxyvitamin D3 Lactate dehydrogenase Interleukin-6 Risk stratification Prognosis |
| 基金项目:河北省2019年度医学科学研究计划项目（20190828） |
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| 中文摘要: |
| 摘要 目的：探讨急性淋巴细胞白血病（ALL）患儿血清25羟维生素D3（25-OH-D3）、乳酸脱氢酶（LDH）、白细胞介素-6（IL-6）水平与危险度分层和预后不良的关系。方法：选择2018年6月至2019年8月在我院住院治疗的ALL患儿60例为病例组，另选取同期到我院健康查体的同龄健康儿童60例为对照组。采用酶联免疫吸附试验（ELISA）检测血清25-OH-D3和IL-6水平，采用全自动生化分析仪检测血清LDH水平，对比病例组与对照组血清25-OH-D3、LDH、IL-6水平，对比不同危险度分层ALL患儿血清25-OH-D3、LDH、IL-6水平，分析其与危险度分层的相关性。ALL患儿进行规范化治疗，根据治疗结果分为预后良好组和预后不良组，对比预后良好组和预后不良组临床特征及血清25-OH-D3、LDH、IL-6水平，采用COX比例风险回归模型分析预后不良的危险因素。结果：病例组患儿血清25-OH-D3水平低于对照组，血清LDH、IL-6水平高于对照组（P＜0.05）。低危型、中危型ALL患儿血清25-OH-D3水平高于高危型，且低危型高于中危型（P＜0.05）；低危型、中危型ALL患儿血清LDH、IL-6水平低于高危型，且低危型低于中危型（P＜0.05）。预后不良组高危型患儿及白细胞计数＞100×109/L的患儿所占比例、血清LDH及IL-6水平高于预后良好组（P＜0.05），血清25-OH-D3水平低于预后良好组（P＜0.05）。血清25-OH-D3水平与ALL患儿危险度分层呈负相关（P＜0.05），血清LDH、IL-6水平与ALL患儿危险度分层呈正相关（P＜0.05）。危险度分层及血清25-OH-D3、LDH、IL-6是ALL患儿预后不良的危险因素（P＜0.05）。结论：ALL患儿血清25-OH-D3、LDH、IL-6水平异常改变，与危险度分层相关，是预后不良的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between serum levels of 25 hydroxyvitamin D3 (25-OH-D3), lactate dehydrogenase (LDH), interleukin-6 (IL-6) and risk stratification and prognosis in children with acute lymphoblastic leukemia (ALL). Methods: The 60 children with all hospitalized in our hospital from June 2018 to August 2019 were selected as the case group, and another 60 healthy children of the same age who came to our hospital for physical examination in the same period were selected as the control group. The levels of serum 25-OH-D3 and IL-6 were detected by enzyme-linked immunosorbent assay(ELISA), and the levels of serum LDH were detected by automatic biochemical analyzer. The levels of serum 25-OH-D3, LDH and IL-6 in case group and control group were compared. The levels of serum 25-OH-D3, LDH and IL-6 in children with all in different risk stratification were compared, and their correlation with risk stratification was analyzed. According to the treatment results, all children were divided into good prognosis group and poor prognosis group. The clinical characteristics and serum levels of 25-OH-D3, LDH and IL-6 were compared between good prognosis group and poor prognosis group. Cox proportional hazards regression model was used to analyze the risk factors of poor prognosis. Results: The levels of serum 25-OH-D3 in the case group were lower than those in the control group, and the levels of serum LDH and IL-6 were higher than those in the control group(P<0.05). The level of serum 25-OH-D3 in children with low-risk and medium-risk ALL was higher than that in high-risk type, and the level of low-risk type was higher than that in medium-risk type (P<0.05); The levels of serum LDH and IL-6 in children with low-risk and medium-risk ALL were lower than those in high-risk type, and the levels of low-risk type were lower than those in medium-risk type (P<0.05). High risk children in poor prognosis group and leukocyte count ＞100×109/L of children and the levels of serum LDH and IL-6 were higher than those in the good prognosis group(P<0.05), and the level of serum 25-OH-D3 was lower than those in the good prognosis group(P<0.05). The levels of serum 25-OH-D3 were negatively correlated with the risk stratification of all children (P<0.05), and the levels of serum LDH and IL-6 were positively correlated with the risk stratification of all children (P<0.05). Risk stratification and serum 25-OH-D3, LDH and IL-6 were risk factors for poor prognosis in children with ALL(P<0.05). Conclusion: The abnormal changes of serum 25-OH-D3, LDH and IL-6 levels in children with ALL are related to the risk stratification and are risk factors for poor prognosis. |
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